丙-2-烯酸酯 | 10344-93-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 丙-2-烯酸酯
• 英文名称: acrylate
• 英文别名: Acrylat-Anion；2-propenoate；prop-2-enoate
• CAS: 10344-93-1
• 化学式: C₃H₃O₂
• 分子量: 71.0556
• InChiKey: NIXOWILDQLNWCW-UHFFFAOYSA-M

物化性质

• 沸点：
  29 °C(Press: 18 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  三正丁胺 、 丙-2-烯酸酯 生成 Acrylate tributylamine
  参考文献：
  名称：

  Compositions for tissue augmentation

  摘要：

  本文介绍了用于增强软组织和硬组织的生物材料制备方法，包含用于形成生物材料的前体物的套件以及所得到的生物材料。生物材料由至少一个第一和第二前体组分形成。第一前体组分含有至少两个亲核基团，第二前体组分含有至少两个电荷亲合基团。第一和第二前体组分的亲核基团和电荷亲合基团在生理温度下形成共价键。前体物根据所需的生物材料性质进行选择。在首选实施例中，第一前体是硅氧烷。可选地，生物材料含有添加剂，如流变剂、放射性不透明剂或生物活性剂。在首选实施例中，生物材料用于增强脊柱的至少一个椎体（椎体成形术）。

  公开号：

  US08282912B2
• 作为产物：
  描述：

  丙烯酰胺 、 水 生成 丙-2-烯酸酯 、 铵
  参考文献：
  名称：

  The AmiE aliphatic amidase and AmiF formamidase of Helicobacter pylori: natural evolution of two enzyme paralogues

  摘要：

  Aliphatic amidases (EC 3.5.1.4) are enzymes catalysing the hydrolysis of short‐chain amides to produce ammonia and the corresponding organic acid. Such an amidase, AmiE, has been detected previously in Helicobacter pylori. Analysis of the complete H. pylori genome sequence revealed the existence of a duplicated amidase gene that we named amiF. The corresponding AmiF protein is 34% identical to its AmiE paralogue. Because gene duplication is widely considered to be a fundamental process in the acquisition of novel enzymatic functions, we decided to study and compare the functions of the paralogous amidases of H. pylori. AmiE and AmiF proteins were overproduced in Escherichia coli and purified by a two‐step chromatographic procedure. The two H. pylori amidases could be distinguished by different biochemical characteristics such as optimum pH or temperature. AmiE hydrolysed propionamide, acetamide and acrylamide and had no activity with formamide. AmiF presented an unexpected substrate specificity: it only hydrolysed formamide. AmiF is thus the first formamidase (EC 3.5.1.49) related to aliphatic amidases to be described. Cys‐165 in AmiE and Cys‐166 in AmiF were identified as residues essential for catalysis of the corresponding enzymes. H. pylori strains carrying single and double mutations of amiE and amiF were constructed. The substrate specificities of these enzymes were confirmed in H. pylori. Production of AmiE and AmiF proteins is dependent on the activity of other enzymes involved in the nitrogen metabolism of H. pylori (urease and arginase respectively). Our results strongly suggest that (i) the H. pylori paralogous amidases have evolved to achieve enzymatic specialization after ancestral gene duplication; and (ii) the production of these enzymes is regulated to maintain intracellular nitrogen balance in H. pylori.

  DOI：

  10.1046/j.1365-2958.2001.02400.x
• 作为试剂：
  描述：

  ethyl 2-(tert-butoxycarbonyl)-2-(difluoromethyl)-4-methylvalerate 在 三氟乙酸 、 oil 、 四氢呋喃 、 sodium hydroxide 、 乙醚 、 丙-2-烯酸酯 作用下， 以 三氟乙酸 为溶剂， 反应 1.25h， 生成 (E)-Ethyl 2-Isobutyl-3-fluoroacrylate
  参考文献：
  名称：

  Method of treating parkinson's syndrome

  摘要：

  新型非芳香族氟丙烯胺是有效的MAO抑制剂，低剂量下选择性抑制MAO-B。它们可用于治疗抑郁症，并与L-多巴胺和脱羧酶抑制剂联合使用，用于治疗帕金森病。

  公开号：

  US04916151A1

文献信息

• Process for producing aromatic compounds
  申请人：——

  公开号：US20030171625A1

  公开（公告）日：2003-09-11

  A process produces an aromatic compound by bringing an aromatic compound (B) into contact with molecular oxygen (C) in the presence of a catalyst (A) comprising at least one of (A1) a heteropolyacid and/or a salt thereof, and (A2) a mixture of oxoacids and/or salts thereof containing, as a whole, one of P and Si and at least one selected from V, Mo and W to thereby yield another aromatic compound (G) than the aromatic compound (B). The process can produce, for example, a corresponding aromatic hydroxy compound (G1) by allowing the aromatic compound (B) to react with the molecular oxygen (C) further in the presence of a reducing agent (D).

  一种过程通过将芳香化合物（B）与分子氧（C）在催化剂（A）的存在下接触，其中催化剂（A）包括至少一种（A1）杂多酸和/或其盐，以及（A2）氧酸和/或其盐的混合物，作为整体，其中包含P和Si中的至少一种，以及至少选择从V，Mo和W中的一种，从而产生比芳香化合物（B）更具芳香性的另一种芳香化合物（G）。例如，在还原剂（D）的存在下，通过使芳香化合物（B）在分子氧（C）的进一步反应中发生反应，该过程可以产生相应的芳香羟基化合物（G1）。
• Modified carboxylated polyolefins and their use as adhesion promoters
  申请人：——

  公开号：US20040072960A1

  公开（公告）日：2004-04-15

  The present invention provides solvent- and water-based primer compositions that include at least one carboxylated polyolefin that has been modified with one or more polyfunctional alcohols. The carboxylated polyolefins are obtained by the reaction of polyolefins with at least one of unsaturated carboxylic esters, unsaturated carboxylic acids, unsaturated carboxylic anhydrides, acrylic monomers, and mixtures thereof. The carboxylated polyolefins are then further modified by reaction with one or more polyfunctional alcohols. These polyfunctional alcohol-modified polyolefins may also contain pendant carboxyl groups, which have the propensity to form hydrophilic salts with amines or inorganic bases, thereby rendering the polyfunctional alcohol-modified polyolefins water-dispersible. These primer compositions are useful for significantly improving the adhesion of paints, adhesives, and inks to various plastic and metal substrates.

  本发明提供了溶剂型和水性底漆组合物，其中包括至少一种已经经过一种或多种多官能醇修饰的羧化聚烯烃。这些羧化聚烯烃是通过聚烯烃与不饱和羧酸酯、不饱和羧酸、不饱和羧酸酐、丙烯酸单体及其混合物之一的反应得到的。然后，这些羧化聚烯烃通过与一种或多种多官能醇的反应进一步修饰。这些多官能醇修饰的聚烯烃也可能含有挂链羧基，这些羧基具有与胺或无机碱形成亲水性盐的倾向，从而使多官能醇修饰的聚烯烃变得可分散于水中。这些底漆组合物可用于显著提高涂料、粘合剂和油墨附着于各种塑料和金属基材上的能力。
• Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors
  申请人：——

  公开号：US20020183369A1

  公开（公告）日：2002-12-05

  This invention relates to compounds of Formula I 1 or stereoisomers, pharmaceutically acceptable salts or prodrugs thereof or a pharmaceutically acceptable salts of the prodrugs. This invention also relates to pharmaceutical compositions comprising a compound of Formula I, and to methods of treatment of diabetes, insulin resistance, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis, or tissue ischemia.

  本发明涉及公式I1的化合物或其立体异构体，其药学上可接受的盐或前药的药学上可接受的盐。本发明还涉及包含公式I的化合物的制药组合物，以及治疗糖尿病、胰岛素抵抗、糖尿病神经病变、糖尿病肾病、糖尿病视网膜病变、白内障、高血糖、高胆固醇血症、高血压、高胰岛素血症、高脂血症、动脉硬化或组织缺血的治疗方法。
• Method for lowering serum glucose
  申请人：GelTex Pharmaceutical, Inc.

  公开号：US20020187121A1

  公开（公告）日：2002-12-12

  A method for treating hyperglycemia and/or reducing serum glucose levels in a patient that includes administering to the patient a therapeutically effective amount of an amine polymer is disclosed. In one embodiment, the amine polymer is aliphatic. Examples of polymers useful in an embodiment of the invention include sevelamer hydrogen chloride and colesevelam. The invention includes the use of amine polymers such as a cross-linked polymer characterized by a repeat unit having the formula: 1 and salts and copolymers thereof, where n is a positive integer and x is zero or an integer between 1 and about 4. Also described is a use, for the manufacture of a medicament, of a polymer that lowers serum glucose.

  本发明公开了一种治疗高血糖和/或降低患者血清葡萄糖水平的方法，包括向患者投予治疗有效量的胺基聚合物。在一种实施例中，胺基聚合物是脂肪族的。本发明的实施例中有用的聚合物的例子包括盐酸西韦拉酰胺和考来西韦。本发明包括使用胺基聚合物，例如交联聚合物，其特征在于重复单元具有公式1，以及其盐和共聚物，其中n是正整数，x为零或介于1和约4之间的整数。本发明还描述了一种用于制造药物的降低血清葡萄糖的聚合物的用途。
• Transition metal complex catalysts
  申请人：Exxon Research and Engineering

  公开号：US04668809A1

  公开（公告）日：1987-05-26

  Compositions of matter are disclosed which are highly useful in hydroformylation processes. The compositions are non-charged, non-chelated bis- and tris-(alkyl diaryl phosphine) rhodium carbonyl hydrides. The substituents of the alkyl group includes heteroorganic radicals containing ether, ester, keto and hydroxy oxygen, phosphine oxide and phosphorus ester phosphorus, amine, amide, amine oxide and heterocyclic nitrogen groups. These compositions are highly stable and selective catalysts for the hydroformylation of olefins under certain conditions. The disclosed catalyst systems contain a large excess of phosphine ligand and employ alpha-olefin plus synthesis gas reactant mixtures having a high H.sub.2 /CO ratio at relatively low pressures. They produce moslty aldehydes derived from terminal attack on the alpha-olefin reactant. In the case of low olefins, such as butene-1, the products can be advantageously removed in a continuous manner, as distillate components from a ligand reaction mixture kept at an elevated temperature and continuously fed by an appropriate mixture of the reactants.

  本发明披露了一种在氢甲酰化过程中非常有用的物质组成物。该组成物是非带电、非螯合的双(烷基二芳基膦)、三(烷基二芳基膦)铑羰基氢化物。烷基基团的取代基包括含有醚、酯、酮和羟基氧、膦氧和磷酸酯磷、胺、酰胺、胺氧和杂环氮基的杂有机基团。这些组成物是高度稳定和选择性的催化剂，可在一定条件下用于烯烃的氢甲酰化反应。披露的催化剂体系含有大量的膦配体，并采用具有高H.sub.2/CO比的α-烯烃加合物和合成气反应物混合物，在相对较低的压力下。它们主要产生从α-烯烃反应物的末端攻击中得到的醛。对于低烯烃，例如丁烯-1，可以从保持在高温下并由适当的反应物混合物连续供给的配体反应混合物中以馏分组分的形式优势地去除产物。