Furfuryl 3-(4-methoxyphenoxy)propyl ether

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Furfuryl 3-(4-methoxyphenoxy)propyl ether
• 英文别名: 2-[3-(4-Methoxyphenoxy)propoxymethyl]furan；2-[3-(4-methoxyphenoxy)propoxymethyl]furan
• 化学式: C₁₅H₁₈O₄
• 分子量: 262.306
• InChiKey: BEAXBGZLHRPJNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(2-Furanylmethoxy)-1-propanol 在 吡啶 、 sodium 作用下， 反应 16.0h， 生成 Furfuryl 3-(4-methoxyphenoxy)propyl ether
  参考文献：
  名称：

  Synthesis and biological activity of furanyl anti-juvenile hormonal compounds

  摘要：

  AbstractTwenty‐one synthetic compounds, containing one or more furan rings, were demonstrated to possess anti‐juvenile hormone (AJH) activity as evidenced by their induction of premature metamorphosis in the milkweed bug, Oncopeltus fasciatus (Dallas) by contact, topical application or fumigation. The ED50 of the four most active analogs required to induce precocious metamorphosis from 3rd‐instar nymphs by residue contact in a Petri dish compared favorably with that of precocene II (6,7‐dimethoxy‐2,2‐dimethyl 2H‐chromene) a naturally occurring phytochemical AJH. Precocious metamorphosis was fully reversible by co‐treatment with juvenile hormone (JH III) or JH analogs, demonstrating that the observed AJH activity resulted from an induced deficiency of juvenile hormone.

  DOI：

  10.1002/ps.2780430102

文献信息

• Synthesis and biological activity of furanyl anti-juvenile hormonal compounds
  作者：William S. Bowers、Gopalan C. Unnithan、Jun-Ichi Fukushima、Jun Toda、Takeyoshi Sugiyama

  DOI：10.1002/ps.2780430102

  日期：1995.1

  AbstractTwenty‐one synthetic compounds, containing one or more furan rings, were demonstrated to possess anti‐juvenile hormone (AJH) activity as evidenced by their induction of premature metamorphosis in the milkweed bug, Oncopeltus fasciatus (Dallas) by contact, topical application or fumigation. The ED50 of the four most active analogs required to induce precocious metamorphosis from 3rd‐instar nymphs by residue contact in a Petri dish compared favorably with that of precocene II (6,7‐dimethoxy‐2,2‐dimethyl 2H‐chromene) a naturally occurring phytochemical AJH. Precocious metamorphosis was fully reversible by co‐treatment with juvenile hormone (JH III) or JH analogs, demonstrating that the observed AJH activity resulted from an induced deficiency of juvenile hormone.