(rac.)-3-[6-(4-fluorophenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (rac.)-3-[6-(4-fluorophenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane
• 英文别名: 3-[6-(4-fluorophenyl)pyridazin-3-yl]oxy-1-azabicyclo[2.2.2]octane
• 化学式: C₁₇H₁₈FN₃O
• 分子量: 299.348
• InChiKey: BHXMOCYYBAPUGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-氯-6-(4-氟苯基)吡嗪 、 奎宁环-3-醇 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 7.0h， 生成 (rac.)-3-[6-(4-fluorophenyl)-pyridazin-3-yloxy]-1-aza-bicyclo[2.2.2]octane
  参考文献：
  名称：

  [EN] AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONIST
  [FR] ETHERS D'AZA-BICYCLOALKYLE ET LEUR UTILISATION EN TANT QU'AGONISTE DE ALPHA7-NACHR

  摘要：

  本发明涉及式(I)的1-aza-双环烷基衍生物，其中X是CH2或单键；Y是式(II, III, IV)的一个基团，其中R的含义如规范中定义的那样，这些化合物是α7烟碱型乙酰胆碱受体(nAChR)激动剂；以及它们的生产过程，作为药物的使用以及包含它们的药物组合物。

  公开号：

  WO2004022556A1

文献信息

• AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS
  申请人：Novartis AG

  公开号：US20170112814A1

  公开（公告）日：2017-04-27

  The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH 2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

  本发明涉及式I的1-aza-bicycloalkyl衍生物，其中X是CH2或单键；Y是式的基团，其中R的含义如规范中所定义，这些化合物是α7尼古丁乙酰胆碱受体(nAChR)激动剂；以及它们的生产过程，它们作为药物的用途以及包含它们的药物组合物。
• Aza-bicycloalkyl ethers and their use as alpha7-nachr agonists
  申请人：Feuerbach Dominik

  公开号：US20060167002A1

  公开（公告）日：2006-07-27

  The present invention relates to 1-aza-bicycloalkyl derivatives of formula (I), wherein X is CH 2 or a single bond; Y is a group of formula (II, III, IV) and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

  本发明涉及式(I)的1-aza-bicycloalkyl衍生物，其中X为CH2或单键；Y为式(II、III、IV)的基团，其中R的含义如规范所定义，这些化合物是α7烟碱型乙酰胆碱受体（nAChR）激动剂；其生产过程，它们作为药物的用途以及包含它们的药物组合物。
• Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists
  申请人：Novartis AG

  公开号：US08236803B2

  公开（公告）日：2012-08-07

  The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

  本发明涉及式I的1-aza-bicycloalkyl衍生物，其中X是CH2或单键；Y是式的群体，其中R的含义如规范中定义，这些化合物是α7尼古丁乙酰胆碱受体（nAChR）激动剂；它们的生产过程，它们作为药物的用途以及包含它们的药物组合物。
• AZA-BICYLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS
  申请人：Novartis AG

  公开号：US20150183794A1

  公开（公告）日：2015-07-02

  The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH 2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

  本发明涉及式I的1-aza-bicycloalkyl衍生物，其中X为CH2或单键；Y为公式的基团，其中R的含义如规范中定义的那样，这些化合物是α7尼古丁乙酰胆碱受体（nAChR）激动剂；其生产过程，它们作为药物的用途以及包含它们的药物组合物。
• Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists
  申请人：Feuerbach Dominik

  公开号：US09012451B2

  公开（公告）日：2015-04-21

  The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

  本发明涉及式I的1-aza-bicycloalkyl衍生物，其中X为CH2或单键；Y为公式的基团，其中R的含义如规范中所定义，这些化合物是α7尼古丁乙酰胆碱受体（nAChR）激动剂；本发明还涉及它们的制备过程，它们作为药物的用途以及包含它们的制药组合物。