丙烷,2-氯-1,1,1,2-四氟- | 5626-40-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 丙烷,2-氯-1,1,1,2-四氟-
• 英文名称: 1-(Carboxymethyl)proline
• 英文别名: 1-(carboxymethyl)pyrrolidine-2-carboxylic acid
• CAS: 5626-40-4
• 化学式: C₇H₁₁NO₄
• 分子量: 173.17
• InChiKey: ZCIXWIPMALYWJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Automated Synthesis of Small Molecules Using Chiral, Non-Racemic Boronates
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20150329567A1

  公开（公告）日：2015-11-19

  Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.

  提供了制备和使用手性的非外消旋保护有机硼酸的方法，包括蒎烯衍生的亚胺二乙酸（PIDA）硼酸酯，以引导和促进有机分子的立体选择性合成。还提供了从溶液中纯化PIDA硼酸酯的方法。还提供了从PIDA配体中去保护硼酸的方法。纯化和去保护方法可与偶联或其他反应硼酸的方法结合使用。可以执行去保护、偶联和纯化的迭代循环来合成手性的非外消旋化合物。该方法适用于自动化化学合成过程。还提供了一种自动化小分子合成器装置，用于执行自动化的立体选择性合成手性的非外消旋小分子，使用去保护、偶联和纯化的迭代循环。
• Peptide purification by means of hard metal ion affinity chromatography
  申请人：Hearn Milton Thomas William

  公开号：US20090143529A1

  公开（公告）日：2009-06-04

  A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group which comprises at least 3 nitrogen donor atoms in the ring of the cyclic group, at least one of the nitrogen atoms having an optionally substituted carboxy(lower alkyl) or optionally substituted phosphono(lower alkyl) group covalently attached thereto, is well suited for use in conjunction with “hard” metal ions of low toxicity (such as Ca 2+ , Mg 2+ or Fe 3+ ) in the separation/purification of appropriately “tagged” polypeptides by Immobilized Metal ion Affinity Chromatography (IMAC).

  一种聚合物基底，其功能化包括至少一个环状金属离子配位配体基团，该基团在环状结构中至少包含3个氮供体原子，其中至少一个氮原子具有可选择性取代的羧酸（较低烷基）或可选择性取代的膦酸（较低烷基）基团共价连接，非常适合与低毒性的“硬”金属离子（例如Ca2+，Mg2+或Fe3+）一起在固定金属离子亲和层析（IMAC）中用于分离/纯化适当“标记”的多肽。
• Automated synthesis of small molecules using chiral, non-racemic boronates
  申请人：The Board of Trustees of the University of Illinois

  公开号：US10239824B2

  公开（公告）日：2019-03-26

  Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.

  本发明提供了制作和使用手性、非气相保护有机硼酸（包括蒎烯衍生亚氨基二乙酸（PIDA）硼酸盐）的方法，以指导和实现有机分子的立体选择性合成。此外，还提供了从溶液中纯化 PIDA 硼酸盐的方法。还提供了从 PIDA 配体中对硼酸进行脱保护的方法。纯化和脱保护方法可与硼酸的偶联或其他反应方法结合使用。去保护、偶联和纯化的迭代循环可用于合成手性非外消旋化合物。这些方法适用于自动化化学合成工艺。此外，还提供了一种自动化小分子合成装置，可利用去保护、偶联和纯化的迭代循环，自动立体选择性合成手性非外消旋小分子。
• Composition and its use for imparting water repellency to leather or furskins, textiles and other fibrous materials
  申请人：Eigen Peter

  公开号：US20050148702A1

  公开（公告）日：2005-07-07

  Compositions comprising a mineral oil or wax and a liquid polysiloxane substituted by functional groups, an anionic surfactant and additionally a molecular mono- or polycarboxylic acid and optionally any emulsifiable, hydrophilic or amphiphilic polymer comprising carboxyl groups are outstanding water repellents for leather, furskins, textiles and fibrous materials.

  由矿物油或蜡和被官能团取代的液态聚硅氧烷、阴离子表面活性剂以及单羧酸或多羧酸分子和可选的包含羧基的任何可乳化的亲水或两性聚合物组成的复合物是皮革、毛皮、纺织品和纤维材料的出色防水剂。
• PEPTIDE PURIFICATION BY MEANS OF METAL ION AFFINITY CHROMATOGRAPHY
  申请人：NOVO NORDISK A/S

  公开号：EP1446426A2

  公开（公告）日：2004-08-18