1-phenyl-5-benzamidopyrazole-4-[N-(p-chlorophenyl)carboxamide]

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-phenyl-5-benzamidopyrazole-4-[N-(p-chlorophenyl)carboxamide]
• 英文别名: 5-benzamido-N-(4-chlorophenyl)-1-phenylpyrazole-4-carboxamide
• 化学式: C₂₃H₁₇ClN₄O₂
• 分子量: 416.867
• InChiKey: BJVCPILJBFUGIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对氯苯胺 、 1,6-diphenylpyrazolo<3,4-d>-1,3-oxazin-4(1H)-one 在 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 4.0h， 生成 1-phenyl-5-benzamidopyrazole-4-[N-(p-chlorophenyl)carboxamide]
  参考文献：
  名称：

  Phenylamides of 1-Phenyl (or Methyl)-5-benzamidopyrazole-4-carboxylic Acid as Vratizolin Analogs with Analgesic and Antiinflammatory Activities

  摘要：

  A number of phenylamides of 5 -benzamidopyrazole-4-carboxylic acid were prepared in 50-80 % yields from 1-phenyl (or methyl)-6-phenylpyrazolo[3,4-d] 1,3-oxazin-4(1 H)-ones and aniline derivatives. All the compounds were tested for their analgesic and antiinflammatory activities, as well as for their ulcerogenic potential and acute toxicity. Some derivatives, when compared to phenylbutazone, proved more active in the tests for analgesic and antiexudative activities, but less active in the carrageenin paw oedema test. The compounds proved to posses marginal or no ulcerogenic effect, as well as low systemic toxicity.

  DOI：

  10.1002/1521-4184(200105)334:5<153::aid-ardp153>3.0.co;2-7

文献信息

• Phenylamides of 1-Phenyl (or Methyl)-5-benzamidopyrazole-4-carboxylic Acid as Vratizolin Analogs with Analgesic and Antiinflammatory Activities
  作者：Giuseppe Daidone、Fabiana Plescia、Benedetta Maggio、Demetrio Raffa、Vincenza Maria Catena Cutuli、Nunzio Guido Mangano、Antonina Caruso

  DOI：10.1002/1521-4184(200105)334:5<153::aid-ardp153>3.0.co;2-7

  日期：2001.5

  A number of phenylamides of 5 -benzamidopyrazole-4-carboxylic acid were prepared in 50-80 % yields from 1-phenyl (or methyl)-6-phenylpyrazolo[3,4-d] 1,3-oxazin-4(1 H)-ones and aniline derivatives. All the compounds were tested for their analgesic and antiinflammatory activities, as well as for their ulcerogenic potential and acute toxicity. Some derivatives, when compared to phenylbutazone, proved more active in the tests for analgesic and antiexudative activities, but less active in the carrageenin paw oedema test. The compounds proved to posses marginal or no ulcerogenic effect, as well as low systemic toxicity.