N-cyclohexyl-N-(difluoromethyl)-N,N-dimethylammonium iodide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-cyclohexyl-N-(difluoromethyl)-N,N-dimethylammonium iodide
• 英文别名: Cyclohexyl-(difluoromethyl)-dimethylazanium;iodide
• 化学式: C₉H₁₈F₂N*I
• 分子量: 305.15
• InChiKey: BKAPDQLRUFMPTF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.38
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  氟里昂-22 、 N,N-二甲基环己胺 在 sodium hydroxide 、 sodium iodide 作用下， 以 四氢呋喃 、 水 为溶剂， 以69%的产率得到N-cyclohexyl-N-(difluoromethyl)-N,N-dimethylammonium iodide
  参考文献：
  名称：

  Difluoromethyltrialkylammonium SaltsTheir Expeditious Synthesis from Chlorodifluoromethane and Tertiary Amines in the Presence of Concentrated Aqueous Sodium Hydroxide. The Catalytic Process

  摘要：

  [GRAPHICS]We found that difluorocarbene generated from chlorodifluoromethane with 50% aqueous sodium hydroxide reacts with lipophilic tertiary amines 1a-g giving difluoromethyltrialkylammonium chlorides 2a-g in high yields. Similarly, difluoromethyltrialkylammonium iodides 3h-l, nitrates 4h-k, or isothiocyanates 5i,j were synthesized from hydrophilic tertiary amines 1h-l and the corresponding sodium or potassium salts. The process is catalytic with respect to the base used.

  DOI：

  10.1021/jo701735n

文献信息

• Difluoromethyltrialkylammonium SaltsTheir Expeditious Synthesis from Chlorodifluoromethane and Tertiary Amines in the Presence of Concentrated Aqueous Sodium Hydroxide. The Catalytic Process
  作者：Ewelina Nawrot、Andrzej Joñczyk

  DOI：10.1021/jo701735n

  日期：2007.12.1

  [GRAPHICS]We found that difluorocarbene generated from chlorodifluoromethane with 50% aqueous sodium hydroxide reacts with lipophilic tertiary amines 1a-g giving difluoromethyltrialkylammonium chlorides 2a-g in high yields. Similarly, difluoromethyltrialkylammonium iodides 3h-l, nitrates 4h-k, or isothiocyanates 5i,j were synthesized from hydrophilic tertiary amines 1h-l and the corresponding sodium or potassium salts. The process is catalytic with respect to the base used.