4-difluoromethoxy-2-fluorobenzyl alcohol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-difluoromethoxy-2-fluorobenzyl alcohol
• 英文别名: (4-(Difluoromethoxy)-2-fluorophenyl)methanol；[4-(difluoromethoxy)-2-fluorophenyl]methanol
• 化学式: C₈H₇F₃O₂
• 分子量: 192.138
• InChiKey: BLNXINJMAOMJDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-氟苯酚 在 氢氧化钾 、 聚合甲醛 作用下， 以 水 为溶剂， 生成 4-difluoromethoxy-2-fluorobenzyl alcohol
  参考文献：
  名称：

  Novel piperazine derivatives

  摘要：

  本发明是一种具有公式(I)的化学化合物 1 或其药物可接受的盐、溶剂化物和酯，其中R 1 至R 4 ，A 1 ，A 2 ，m和n如说明书中所述。

  公开号：

  US20020143020A1

文献信息

• AMINOAZOLE DERIVATIVE
  申请人：Teijin Pharma Limited

  公开号：US20190031628A1

  公开（公告）日：2019-01-31

  A compound, represented by the following formula or a medically acceptable salt thereof, having an effect of regulating the activity of an androgen receptor. In the formula, X represents S, O; Z represents (R a ) n -A- (CR 13 R 14 ) 0-1 —(CR 11 R 12 ) 0-1 ; A represents aryl, heteroaryl; R 1 represents alkyl, cycloalkyl, alkenyl, alkynyl, alkoxyalkyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl; R 2 represents hydrogen, halogen, alkyl, cycloalkyl, phenyl; R3 represents hydrogen, halogen, alkyl, cycloalkyl, alkoxyalkyl, alkenyl, alkynyl, cycloalkenyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl, acyl, cycloalkylcarbonyl, benzoyl, spiroalkyl, adamantyl, silyl, R 31 R 32 NCO—; R 4 and R 5 represent hydrogen, halogen, alkyl, phenyl, and cycloalkyl.

  一种化合物，由以下公式或其医学上可接受的盐表示，具有调节雄激素受体活性的作用。在公式中，X代表S，O；Z代表（R a ）n-A-（CR 13 R 14 ）0-1—（CR 11 R 12 ）0-1；A代表芳基，杂环芳基；R1代表烷基，环烷基，烯基，炔基，烷氧基烷基，芳基，芳基烷基，杂环，杂环烷基；R2代表氢，卤素，烷基，环烷基，苯基；R3代表氢，卤素，烷基，环烷基，烷氧基烷基，烯基，炔基，环烯烯基，芳基，芳基烷基，杂环，杂环烷基，酰基，环烷基羰基，苯甲酰基，螺环烷基，金刚烷基，硅基，R31R32NCO—；R4和R5代表氢，卤素，烷基，苯基和环烷基。
• [EN] TRICYCLIC PIPERIDINE COMPOUNDS<br/>[FR] COMPOSÉS PIPÉRIDINIQUES TRICYCLIQUES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2015075023A1

  公开（公告）日：2015-05-28

  The present invention relates to compounds of the formula (I), wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

  本发明涉及公式（I）的化合物，其中R、R1a、R1b、R2、R3和X如描述中所述，以及它们的制备方法，其药用盐，以及它们作为药物的用途，包括含有一个或多个公式（I）化合物的药物组合物，以及制备这种公式（I）化合物的方法，特别是它们作为TPH调节剂的用途。
• TRICYCLIC PIPERIDINE COMPOUNDS
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：US20160272655A1

  公开（公告）日：2016-09-22

  The present invention relates to compounds of the formula (I) wherein R, R 1a , R 1b , R 2 , R 3 , and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

  本发明涉及式（I）的化合物，其中R、R1a、R1b、R2、R3和X如描述中所述，其制备方法，其药学上可接受的盐以及它们作为药物的用途，含有一个或多个式（I）化合物的药物组合物，制备这种式（I）化合物的方法，特别是它们作为TPH调节剂的用途。
• Aminoazole derivative
  申请人：Teijin Pharma Limited

  公开号：US10689354B2

  公开（公告）日：2020-06-23

  A compound, represented by the following formula or a medically acceptable salt thereof, having an effect of regulating the activity of an androgen receptor. In the formula, X represents S, O; Z represents (Ra)n-A-(CR13R14)0-1—(CR11R12)0-1; A represents aryl, heteroaryl; R1 represents alkyl, cycloalkyl, alkenyl, alkynyl, alkoxyalkyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl; R2 represents hydrogen, halogen, alkyl, cycloalkyl, phenyl; R3 represents hydrogen, halogen, alkyl, cycloalkyl, alkoxyalkyl, alkenyl, alkynyl, cycloalkenyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl, acyl, cycloalkylcarbonyl, benzoyl, spiroalkyl, adamantyl, silyl, R31R32NCO—; R4 and R5 represent hydrogen, halogen, alkyl, phenyl, and cycloalkyl.

  一种由下式代表的化合物或其医学上可接受的盐，具有调节雄激素受体活性的作用。式中，X代表S、O；Z代表(Ra)n-A-(CR13R14)0-1-(CR11R12)0-1；A代表芳基、杂芳基；R1代表烷基、环烷基、烯基、炔基、烷氧基烷基、芳基、芳烷基、杂环、杂环烷基；R2代表氢、卤素、烷基、环烷基、苯基；R3 代表氢、卤素、烷基、环烷基、烷氧基烷基、烯基、炔基、环烯基、芳基、芳烷基、杂环、杂环烷基、酰基、环烷基羰基、苯甲酰基、螺烷基、金刚烷基、硅烷基、R31R32NCO-；R4 和 R5 代表氢、卤素、烷基、苯基和环烷基。
• PIPERAZINE DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP1343775B1

  公开（公告）日：2008-06-04