3-(4-methylpiperidin-1-yl)-N-phenylpropanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(4-methylpiperidin-1-yl)-N-phenylpropanamide
• 化学式: C₁₅H₂₂N₂O
• 分子量: 246.352
• InChiKey: BLYSKUXPYAJHOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-甲基哌啶 、 N-苯基丙烯酰胺 在 C₉H₂₀NO₂⁽¹⁺⁾*C₂H₃O₂^(1-) 作用下， 以 水 为溶剂， 反应 10.0h， 以92%的产率得到3-(4-methylpiperidin-1-yl)-N-phenylpropanamide
  参考文献：
  名称：

  Nmp-based ionic liquids: Recyclable catalysts for both hetero-Michael addition and Knoevenagel condensation in water

  摘要：

  A series of novel N-methyl piperidine (Nmp)-based ionic liquids with 1,2-propanediol group are synthesized and used as catalysts for both hetero-Michael addition of alpha,beta-unsaturated amides and Knoevenagel condensation at room temperature in water; and all the examined substrates could be transformed into corresponding products in good to excellent yields. Meanwhile IL-catalyzed hetero-Michael addition of alpha,beta-unsaturated amides in water has not been reported in the previous literatures. Additionally, the catalyst is recyclable for the two reactions. This finding provides a green catalyst for both hetero-Michael addition of alpha,beta-unsaturated amides and Knoevenagel condensation in water.

  DOI：

  10.1080/00397911.2018.1434544

文献信息

• Nmp-based ionic liquids: Recyclable catalysts for both hetero-Michael addition and Knoevenagel condensation in water
  作者：Pengkun Yang、Yawei Liu、Ling Chai、Zhenzhen Lai、Xiaomin Fang、Baoying Liu、Wenkai Zhang、Minghua Lu、Yuanqing Xu、Hao Xu

  DOI：10.1080/00397911.2018.1434544

  日期：2018.5.3

  A series of novel N-methyl piperidine (Nmp)-based ionic liquids with 1,2-propanediol group are synthesized and used as catalysts for both hetero-Michael addition of alpha,beta-unsaturated amides and Knoevenagel condensation at room temperature in water; and all the examined substrates could be transformed into corresponding products in good to excellent yields. Meanwhile IL-catalyzed hetero-Michael addition of alpha,beta-unsaturated amides in water has not been reported in the previous literatures. Additionally, the catalyst is recyclable for the two reactions. This finding provides a green catalyst for both hetero-Michael addition of alpha,beta-unsaturated amides and Knoevenagel condensation in water.