(3S)-3-(ethylamino)pyrrolidin-2-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S)-3-(ethylamino)pyrrolidin-2-one
• 化学式: C₆H₁₂N₂O
• 分子量: 128.17
• InChiKey: RMQGWKNXRVMQAN-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• INDOLE DERIVATIVES AND USE THEREOF
  申请人：Purdue Pharma L.P.

  公开号：US20150284383A1

  公开（公告）日：2015-10-08

  The Invention provides indole derivatives of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R 1e , R 1f , A, X, Y, Z, and W 4 are defined as set forth in the specification. The Invention also provides the use of compounds of Formula I and the pharmaceutically acceptable salts and solvates thereof to treat pain. In certain embodiments, the Compounds of the Invention are effective in treating a disorder responsive to blockade of one or more sodium channels.

  本发明提供了公式I的吲哚衍生物及其药学上可接受的盐和溶剂化合物，其中R1e、R1f、A、X、Y、Z和W4如规范中所述。本发明还提供了利用公式I的化合物及其药学上可接受的盐和溶剂来治疗疼痛。在某些实施例中，本发明的化合物对于治疗对一个或多个钠通道阻滞有响应的疾病是有效的。
• CARBOXAMIDE DERIVATIVES AND USE THEREOF
  申请人：Purdue Pharma LP

  公开号：EP3666274A1

  公开（公告）日：2020-06-17

  The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein Z, HET, R10, and E are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I-A to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

  本公开提供了式 I-A 的取代吡啶基、嘧啶基、吡嗪基、哒嗪基和三嗪基羧酰胺： 及其药学上可接受的盐和溶液，其中 Z、HET、R10 和 E 的定义如说明书所述。本公开内容还涉及使用式 I-A 的化合物治疗对钠离子通道阻断有反应的疾病。本公开的化合物尤其适用于治疗疼痛。
• Carboxamide Derivatives and Use Thereof
  申请人：PURDUE PHARMA L.P.

  公开号：US20170096421A1

  公开（公告）日：2017-04-06

  The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein Z, HET, R 10 , and E are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I-A to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
• US9493449B2
  申请人：——

  公开号：US9493449B2

  公开（公告）日：2016-11-15