1,3-bis[2-hydroxy-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)propyl]-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1,3-bis[2-hydroxy-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)propyl]-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
• 英文别名: 1,3-bis[2-hydroxy-3-(6-methyl-2,4-dioxo-1H-pyrimidin-3-yl)propyl]-6-methylpyrimidine-2,4-dione
• 化学式: C₂₁H₂₆N₆O₈
• 分子量: 490.473
• InChiKey: BNFUXUBOIPRZPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  180
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,3-bis(2-hydroxy-3-chloropropyl)-6-methyluracil 、 6-methyluracil sodium salt 以 N,N-二甲基甲酰胺 为溶剂， 以83%的产率得到1,3-bis[2-hydroxy-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)propyl]-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
  参考文献：
  名称：

  Synthesis of 5-Alkyl-1,3-bis[2-hydroxy-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)propyl]-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-diones

  摘要：

  6-Methyluracil sodium salt reacts with 1,3-bis(3-chloro-2-hydroxypropyl)-6-methyluracils in DMF, yielding products of alkylation at the nitrogen atom in position 3 of the uracil ring.

  DOI：

  10.1023/b:rujo.0000034982.68023.eb

文献信息

• Synthesis of 5-Alkyl-1,3-bis[2-hydroxy-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)propyl]-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-diones
  作者：V. P. Krivonogov、G. G. Kozlova、E. A. Belaya、G. A. Sivkova、L. V. Spirikhin、I. B. Abdrakhmanov、V. V. Plechev

  DOI：10.1023/b:rujo.0000034982.68023.eb

  日期：2004.3

  6-Methyluracil sodium salt reacts with 1,3-bis(3-chloro-2-hydroxypropyl)-6-methyluracils in DMF, yielding products of alkylation at the nitrogen atom in position 3 of the uracil ring.