7-cyano-1,4-dithiino[2,3-b]quinoxaline-2,3-dicarbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-cyano-1,4-dithiino[2,3-b]quinoxaline-2,3-dicarbonitrile
• 英文别名: [1,4]Dithiino[2,3-b]quinoxaline-2,3,7-tricarbonitrile
• 化学式: C₁₃H₃N₅S₂
• 分子量: 293.332
• InChiKey: BOGYFQAQIZWRKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  148
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6 -氰基喹喔啉-2,3二酮 在 氯化亚砜 、 N,N-二甲基甲酰胺 作用下， 以 水 、 1,2-二氯乙烷 、 丙酮 为溶剂， 反应 10.0h， 生成 7-cyano-1,4-dithiino[2,3-b]quinoxaline-2,3-dicarbonitrile
  参考文献：
  名称：

  Synthesis and fungicidal activity of 1,4-dithiino[2,3-b]quinoxaline-2,3-dicarbonitriles

  摘要：

  AbstractA series of eleven 1,4‐dithiino[2,3‐b]quinoxaline‐2,3‐dicarbonitriles was prepared by reaction of 2,3‐dichloroquinoxalines with disodium (2)‐2,3‐dimercapto‐2‐butenedinitrile in N,N‐dimethylformamide. These products were tested for in‐vitro fungicidal activity by a Minimum Inhibitory Concentration (MIC) method. Several of these compounds showed broad‐spectrum fungicidal activity. The activity exhibited by these compounds was greatly dependent upon the substituents of the quinoxaline ring, with the nitro‐substituted derivatives showing the highest levels of antifungal activity. None of the compounds prepared, however, showed fungicidal activity comparable to that of the commercial fungicides screened.

  DOI：

  10.1002/ps.2780430403

文献信息

• Composition and use of substituted 1,3-dithiolo-and 1,4-dithiinoquinoxalines as an antimicrobial
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0784083A2

  公开（公告）日：1997-07-16

  A composition comprising an effective amount of a compound corresponding to the formula: wherein X represents: and R1 and R2 independently represent hydrogen, halogen, nitro, cyano, alkyl, alkoxy, arylcarbonyl, or an alkoxy carbonyl group, wherein the alkyl, alkoxy, arylcarbonyl, or alkoxy carbonyl may be with or without halogen substituents, provided that at least one of R1 and R2 is a nitro, cyano, alkoxy, alkylcarbonyl, or an alkoxy carbonyl group, together with an inert diluent is useful in preventing the growth of marine organisms on a surface exposed to a marine environment in which marine organisms grow.

  一种组合物，包含有效量的符合式的化合物： 其中 X 代表 以及 R1 和 R2 独立地代表氢、卤素、硝基、氰基、烷基、烷氧基、芳基羰基或烷氧基羰基，其中烷基、烷氧基、芳基羰基或烷氧基羰基可带或不带卤素取代基，条件是 R1 和 R2 中至少有一个是硝基、氰基、烷氧基、烷基羰基或烷氧基羰基，该组合物与惰性稀释剂一起使用，有助于防止暴露在海洋环境中的表面上的海洋生物的生长。
• COMPOSITION AND USE OF SUBSTITUTED 1,3-DITHIOLO- AND 1,4-DITHIINOQUINOXALINES AS AN ANTIMICROBIAL
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0573635A1

  公开（公告）日：1993-12-15
• US5200409A
  申请人：——

  公开号：US5200409A

  公开（公告）日：1993-04-06
• [EN] COMPOSITION AND USE OF SUBSTITUTED 1,3-DITHIOLO- AND 1,4-DITHIINOQUINOXALINES AS AN ANTIMICROBIAL
  申请人：THE DOW CHEMICAL COMPANY

  公开号：WO1993013106A1

  公开（公告）日：1993-07-08

  (EN) Substituted 1,3-dithiolo- and 1,4-dithiinoquinoxalines are prepared which correspond to formula (I), wherein X represents (A) or (B) and R1 and R2 independently represent hydrogen, halogen, nitro, cyano, alkyl, alkoxy, arylcarbonyl, or an alkoxy carbonyl group. These compounds have been found to exhibit antimicrobial and marine antifouling activity in industrial and commercial applications and compositions containing these compounds are so employed.(FR) On a préparé des 1,3-dithiolo- et 1,4-dithiinoquinoxalines substituées correspondant à la formule (I) dans laquelle X représente (A) ou (B), et R1 et R2 représentent indépendamment hydrogène, halogène, nitro, cyano, alkyle, alcoxy, arylcarbonyle ou un groupe carbonyle alcoxy. Ces composés se sont révélés présenter une activité antimicrobienne et antisalissures marines, dans des applications industrielles et commerciales, et les compositions les renfermant sont employées à ce titre.
• Synthesis and fungicidal activity of 1,4-dithiino[2,3-<i>b</i>]quinoxaline-2,3-dicarbonitriles
  作者：Duane R. Romer、Brian L. Aldrich、R. Garth Pews、Richard W. Walter

  DOI：10.1002/ps.2780430403

  日期：1995.4

  AbstractA series of eleven 1,4‐dithiino[2,3‐b]quinoxaline‐2,3‐dicarbonitriles was prepared by reaction of 2,3‐dichloroquinoxalines with disodium (2)‐2,3‐dimercapto‐2‐butenedinitrile in N,N‐dimethylformamide. These products were tested for in‐vitro fungicidal activity by a Minimum Inhibitory Concentration (MIC) method. Several of these compounds showed broad‐spectrum fungicidal activity. The activity exhibited by these compounds was greatly dependent upon the substituents of the quinoxaline ring, with the nitro‐substituted derivatives showing the highest levels of antifungal activity. None of the compounds prepared, however, showed fungicidal activity comparable to that of the commercial fungicides screened.