乙二胺四丙醇 | 5261-23-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 乙二胺四丙醇
• 中文别名: N,N,N,N-四羟丙基乙二胺
• 英文名称: N,N,N',N'-Tetrakis-(3-hydroxy-propyl)-ethylendiamin
• 英文别名: N,N,N',N'-tetrakis(hydroxypropyl)ethylenediamine；tetra(hydroxypropyl) ethylenediamine；N,N,N',N'-tetrakis(3-hydroxypropyl)ethylenediamine；3,3',3'',3'''-(Ethane-1,2-diylbis(azanetriyl))tetrakis(propan-1-ol)；3-[2-[bis(3-hydroxypropyl)amino]ethyl-(3-hydroxypropyl)amino]propan-1-ol
• CAS: 5261-23-4
• 化学式: C₁₄H₃₂N₂O₄
• 分子量: 292.419
• InChiKey: ORAJHYSVXOYBCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  20
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  87.4
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• 海关编码：
  2922199090
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

反应信息

• 作为反应物：
  描述：

  乙二胺四丙醇 在 氯化亚砜 、 potassium hydroxide 作用下， 以 乙醇 为溶剂， 生成 N,N,N',N'-tetrakis(3-(8-quinolyloxy)propyl)ethylenediamine dihydrochloride
  参考文献：
  名称：

  8-TQEN (N,N,N′,N′-tetrakis(8-quinolylmethyl)ethylenediamine) analogs as fluorescent cadmium sensors: strategies to enhance Cd2+-induced fluorescence and Cd2+/Zn2+ selectivity

  摘要：

  为了挖掘TQEN（N,N,N′,N′-四(2-喹啉甲基)乙二胺）系列荧光探针未开发的传感潜力，设计并表征了8-TQEN（N,N,N′,N′-四(8-喹啉甲基)乙二胺）类似物。尽管8-TQEN由于在水介质和有机溶剂中溶解性差而缺乏实用性，但6-MeO-8-TQEN（N,N,N′,N′-四(6-甲氧基-8-喹啉甲基)乙二胺，1b）在DMF-HEPES缓冲液（1：1）中表现出对Cd2+的选择性荧光增强，波长为395 nm（ICd/I0 = 25，λex = 332 nm，φCd = 0.025）。Zn2+引起的荧光增强较弱（IZn/I0 = 9，IZn/ICd = 0.35）。相比之下，母体探针TQEN（IZn/I0 = 23，ICd/IZn = 0.64）和6-MeOTQEN（IZn/I0 = 11，ICd/IZn = 1.29）对Zn2+表现出更高的敏感性。当喹啉基团被8-羟基喹啉取代时，观察到不同的响应。丙二胺衍生物，8-TQOEPN（N,N,N′,N′-四(8-喹啉氧乙烯)丙二胺，2c）在Cd2+结合时在423 nm处表现出显著的荧光增强（λex = 325 nm，ICd/I0 = 19，φCd = 0.31）。荧光增强是Cd2+特异性的，因为Zn2+仅引起更温和的发射增加（IZn/I0 = 8.8，IZn/ICd = 0.45）。

  DOI：

  10.1039/c4ra00010b
• 作为产物：
  描述：

  N,N,N',N'-Tetrakis-<2-methoxycarbonyl-ethyl>-ethylendiamin 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 乙二胺四丙醇
  参考文献：
  名称：

  �ber pharmakodynamisch wirksame 3,4,5-Trimethoxybenzoate und verwandte Ester von symmetrischen Bis-hydroxyalkylpiperazinen und-dialkylpolymethylendiaminen

  摘要：

  DOI：

  10.1007/bf00908805

文献信息

• [EN] HEMI-AMINAL ETHERS AND THIOETHERS OF N-ALKENYL CYCLIC COMPOUNDS<br/>[FR] ÉTHERS ET THIOÉTHERS HÉMIAMINAUX DE COMPOSÉS CYCLIQUES N-ALCÉNYLIQUES
  申请人：ISP INVESTMENTS INC

  公开号：WO2014116560A1

  公开（公告）日：2014-07-31

  Described herein are hemi-aminal ethers and thioethers of N-alkenyl cyclic compounds that may be produced through a reaction comprising: (A) at least one first reactant represented by a structure (I), wherein X is a functionalized or unfunctionalized C1-C5 alkylene group optionally having one or more heteroatoms, and each R1, R2, and R3 is independently selected from the group consisting of hydrogen and functionalized and unfunctionalized alkyl groups optionally having one or more heteroatoms, and (B) at least one second reactant having at least one hydroxyl moiety or thiol moiety. The hemi-aminal ethers and thioethers of N-alkenyl cyclic compounds may comprise a polymerizable moiety, in which case they may be left as-is or used to create homopolymers or non-homopolymers, or they may not comprise a polymerizable moiety. A wide variety of formulations may be created using the hemi-aminal ethers and thioethers of N-alkenyl cyclic compounds, including personal care, oilfield, and construction formulations.

  本文描述了可以通过反应制备的N-烯基环状化合物的半胺醚和硫醚，所述反应包括：（A）至少一个由结构（I）表示的第一反应物，其中X是一个官能化或非官能化的C1-C5烷基烯烃基团，可选地具有一个或多个杂原子，每个R1、R2和R3分别独立地选自氢和官能化和非官能化的烷基基团，可选地具有一个或多个杂原子；和（B）至少一个具有至少一个羟基基团或硫醇基团的第二反应物。N-烯基环状化合物的半胺醚和硫醚可能包括一个可聚合的基团，此时它们可以保持原样或用于制备同聚物或非同聚物，或者它们可能不包括可聚合的基团。可以使用N-烯基环状化合物的半胺醚和硫醚制备各种配方，包括个人护理、油田和建筑配方。
• Branched Polymeric Emulsifiers
  申请人：Lubrizol Advanced Materials, Inc.

  公开号：US20150218312A1

  公开（公告）日：2015-08-06

  The present invention relates to esterified glycerylated alkyl glycoside and to a process for making same. The esterified glycerylated alkyl glycoside have one or more polyglyceryl moieties and one or more acyl moieties, wherein all of the one or more acyl moieties are situated on the one or more polyglyceryl moieties via an ester linkage. These compounds have been found to be useful as emulsifiers and coemulsifiers in the formulation of a phase stable emulsions suitable for use in personal care, home care, industrial and institutional, and health care applications.

  本发明涉及酯化的甘油化烷基葡糖苷以及制备该化合物的方法。所述的酯化的甘油化烷基葡糖苷具有一个或多个聚甘油基团和一个或多个酰基团，其中所有的一个或多个酰基团通过酯键位于一个或多个聚甘油基团上。已发现这些化合物在制备适用于个人护理、家庭护理、工业和机构、以及医疗保健应用的相稳定乳化剂和共乳化剂方面具有实用性。
• [EN] AGROCHEMICAL DELIVERY SYSTEM BASED ON ENZYME- OR pH- RESPONSIVE AMPHIPHILIC PEG-DENDRON HYBRIDS<br/>[FR] SYSTÈME D'ADMINISTRATION AGROCHIMIQUE BASÉ SUR DES HYBRIDES PEG-DENDRON AMPHIPHILES RÉAGISSANT AUX ENZYMES OU AU PH
  申请人：UNIV RAMOT

  公开号：WO2016038596A1

  公开（公告）日：2016-03-17

  The present invention relates to an amphiphilic hybrid delivery system in micellar form for delivery of agrochemicals, based on a hydrophilic polyethylene glycol (PEG) polymer conjugated to a hydrophobic dendron, the dendron comprising at least one pH-dependent or enzymatically cleavable hydrophobic end group that is covalently attached to the dendron, wherein the micelle disassembles upon enzymatic or pH-dependent cleavage of the hydrophobic end group. The hydrophobic end group that is conjugated to the dendron may comprise an agrochemical, and/or the micelle may (non-covalently) encapsulate an agrochemical. The present invention further provides methods of use thereof and to a kit comprising same.

  本发明涉及一种用于传递农药的两性混合递送系统，基于一种亲水性聚乙二醇（PEG）聚合物与一种疏水性树状结构（dendron）共轭的微胶束形式，其中该树状结构包含至少一个依赖于pH或酶可切割的疏水性末端基团，该末端基团与树状结构共价结合，微胶束在酶切或依赖于pH的条件下解离。与树状结构共轭的疏水性末端基团可能包含一种农药，和/或微胶束可能（非共价地）封装一种农药。本发明还提供了使用方法以及包含相同的试剂盒。
• Associative thickeners for aqueous systems
  申请人：Lai Ta-Yuan John

  公开号：US20060039939A1

  公开（公告）日：2006-02-23

  Thiocarbonate compounds which, in one embodiment, are utilized as a rheology modifier or associative thickener. The thiocarbonate compounds thicken or increase the viscosity of a composition, preferably an aqueous composition when used in an effective amount. In one preferred embodiment, the thiocarbonate compounds include at least one hydrophilic group containing repeat unit such as derived from acrylic acid, and at least one hydrophobic group to enhance association with other compounds and thus increase viscosity of a composition. Aqueous composition comprising a latex and thiocarbonate associative thickeners are described.

  Thiocarbonate化合物在一种实施方式中被用作流变改性剂或联合增稠剂。当以有效量使用时，这些thiocarbonate化合物可以增稠或增加组成物的粘度，特别是水性组成物。在一个优选实施方式中，这些thiocarbonate化合物包括至少一个亲水基团重复单元，例如来自丙烯酸，并且至少一个疏水基团，以增强与其他化合物的结合，从而增加组成物的粘度。描述了包含乳胶和thiocarbonate联合增稠剂的水性组成物。
• Multi-purpose polymers, methods and compositions
  申请人：——

  公开号：US20040241130A1

  公开（公告）日：2004-12-02

  Disclosed are multi-purpose polymers that are the polymerization product of a monomer mixture comprising at least one amino-substituted vinyl monomer; at least one nonionic vinyl monomer; at least one associative vinyl monomer; at least one semihydrophobic vinyl surfactant monomer; and, optionally, comprising one or more hydroxy-substituted nonionic vinyl monomer, crosslinking monomer, chain transfer agent or polymeric stabilizer. These vinyl addition polymers have a combination of substituents, including amino substituents that provide cationic properties at low pH, hydrophobic substituents, hydrophobically modified polyoxyalkylene substituents, and hydrophilic polyoxyalkylene substituents. The polymers provide surprisingly beneficial Theological properties in acidic aqueous compositions, and are compatible with cationic materials. Additionally, this invention relates to the incorporation of a basic material after the addition of an acidic material to reduce the pH of the composition without negatively impacting the viscosity of the composition. The multi-purpose polymers are useful in a variety of products for personal care, health care, household care, institutional and industrial care, and industrial applications.

  本发明涉及多用途聚合物，其为单体混合物的聚合物化产物，包括至少一种氨基取代的乙烯单体；至少一种非离子乙烯单体；至少一种联合乙烯单体；至少一种半亲水性乙烯表面活性剂单体；以及可选地包括一种或多种羟基取代的非离子乙烯单体、交联剂、链转移剂或聚合稳定剂。这些乙烯加成聚合物具有一些取代基的组合，包括在低pH下提供阳离子性质的氨基取代基、疏水取代基、疏水改性的聚氧烷基取代基和亲水性的聚氧烷基取代基。这些聚合物在酸性水性组合物中提供了出乎意料的有益流变特性，并且与阳离子材料兼容。此外，本发明还涉及在添加酸性物质后加入碱性物质以降低组合物的pH值，而不会对组合物的粘度产生负面影响。这些多用途聚合物在个人护理、健康护理、家庭护理、机构和工业护理以及工业应用的各种产品中非常有用。