3-(3,4-dimethoxyphenyl)-4,5,5-trimethyl-3(5H)-furanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3,4-dimethoxyphenyl)-4,5,5-trimethyl-3(5H)-furanone
• 英文别名: 3-(3,4-Dimethoxyphenyl)-4,5,5-trimethylfuran-2-one
• 化学式: C₁₅H₁₈O₄
• 分子量: 262.306
• InChiKey: BPIVNEZHFZJGHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-羟基-3-甲基-2-丁酮 、 3,4-二甲氧基苯乙腈 在 sodium ethanolate 、 盐酸 作用下， 以 乙醇 为溶剂， 反应 0.53h， 以67%的产率得到3-(3,4-dimethoxyphenyl)-4,5,5-trimethyl-3(5H)-furanone
  参考文献：
  名称：

  Application of Microwaves in Organic Synthesis: A Rapid and Efficient Synthesis of New 3-Aryl-2-imino-4-methyl-2,5-dihydrofurans and 3-Aryl-3-2-(5H)-furanones

  摘要：

  New 3-aryl-2-imino-4-methyl-2,5-dihydrofurans (3a-f) were efficiently synthesized by a one-pot condensation under focused microwave irradiation from simple and readily available starting materials. Hydrolysis of (3a-f) gave 3-aryl-4-methyl-2-(5H)-furanones (4a-f).

  DOI：

  10.1081/scc-120018778

文献信息

• Application of Microwaves in Organic Synthesis: A Rapid and Efficient Synthesis of New 3-Aryl-2-imino-4-methyl-2,5-dihydrofurans and 3-Aryl-3-2-(5<i>H</i>)-furanones
  作者：Didier Villemin、Liang Liao

  DOI：10.1081/scc-120018778

  日期：2003.1.5

  New 3-aryl-2-imino-4-methyl-2,5-dihydrofurans (3a-f) were efficiently synthesized by a one-pot condensation under focused microwave irradiation from simple and readily available starting materials. Hydrolysis of (3a-f) gave 3-aryl-4-methyl-2-(5H)-furanones (4a-f).