(2s*,5S*,8AR*)-N-hydroxy-2-methyl-2-{4-[(4-quinolinyl)methoxy]phenyl}-3-oxooctahydro-5-indolizinecarboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2s*,5S*,8AR*)-N-hydroxy-2-methyl-2-{4-[(4-quinolinyl)methoxy]phenyl}-3-oxooctahydro-5-indolizinecarboxamide
• 英文别名: N-hydroxy-2-methyl-3-oxo-2-[4-(quinolin-4-ylmethoxy)phenyl]-1,5,6,7,8,8a-hexahydroindolizine-5-carboxamide
• 化学式: C₂₆H₂₇N₃O₄
• 分子量: 445.518
• InChiKey: BQIIFNWWEFHXNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Bicyclic lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE)
  申请人：——

  公开号：US20030181438A1

  公开（公告）日：2003-09-25

  The present application describes novel bicyclic lactam derivatives of formula I: 1 or pharmaceutically acceptable salt forms thereof, wherein A, B, C, D, R 1 , and R 2 are defined in the present specification, which are useful as metalloprotease, TNF-&agr;, and/or aggrecanase inhibitors.

  本申请描述了公式I的新型双环内酰胺衍生物：1或其药学上可接受的盐形式，其中A、B、C、D、R1和R2在本规范中被定义，它们可用作金属蛋白酶、TNF-α和/或Aggrecanase抑制剂。
• US6884806B2
  申请人：——

  公开号：US6884806B2

  公开（公告）日：2005-04-26
• [EN] BICYCLIC LACTAM DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-alpha CONVERTING ENZYME (TACE)<br/>[FR] DERIVES BICYCLIQUES DE LACTAME UTILISES EN TANT QU'INHIBITEURS DE METALLOPROTEASES MATRICIELLES ET/OU D'ENZYME DE CONVERSION DU TNF-ALPHA (TACE)
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2003055856A2

  公开（公告）日：2003-07-10

  The present application describes novel bicyclic lactam derivatives of formula (I) or pharmaceutically acceptable salt forms th ereof, wherein A, B, C, D, R1, and R2 are defined in the present specification, which are useful as metalloprotease, TNF-α, and/or aggrecanase inhibitors.