(3-oxobutanoyl)-L-cysteine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3-oxobutanoyl)-L-cysteine
• 英文别名: (2R)-2-(3-oxobutanoylamino)-3-sulfanylpropanoic acid
• 化学式: C₇H₁₁NO₄S
• 分子量: 205.235
• InChiKey: JPNUNMASSONUEW-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  84.5
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  L-半胱氨酸 、 2,2,6-三甲基-4H-1,3-二英-4-酮 在 potassium carbonate 作用下， 以 水 为溶剂， 150.0 ℃ 、900.01 kPa 条件下， 反应 0.08h， 以50%的产率得到(3-oxobutanoyl)-L-cysteine
  参考文献：
  名称：

  An efficient green protocol for the preparation of acetoacetamides and application of the methodology to a one-pot synthesis of Biginelli dihydropyrimidines. Expansion of dihydropyrimidine topological chemical space

  摘要：

  一锅法合成Biginelli双氢嘧啶化合物。氨基酸的新颖应用使化学空间具有拓扑多样性。

  DOI：

  10.1039/c5ra14355a

文献信息

• Methods and devices for using mucolytic agents including N-acetyl cysteine (NAC)
  申请人：Rapid Pathogen Screening, Inc.

  公开号：US11002734B2

  公开（公告）日：2021-05-11

  Devices and methods incorporate mucolytic agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters one or more lysis agents and/or mucolytic agents. The mucolytic agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the mucolytic agent is localized between the sample application zone and the conjugate zone. In embodiments with a sample compressor, one or more mucolytic agents may be pre-loaded and dried on the sample compressor, the sample collector, in various locations on the test strip, or in the running buffer.

  设备和方法将粘液溶解剂纳入护理点检测设备。装入样本后，样本会一直移动，直到遇到一种或多种裂解剂和/或粘液溶解剂。粘液溶解剂最好预装在收集装置上。在一个优选的实施方案中，粘液溶解剂位于样品应用区和结合区之间。在带有样品压缩机的实施方案中，可在样品压缩机、样品收集器、试纸条上的不同位置或运行缓冲液中预装和干燥一种或多种粘液溶解剂。
• Methods And Devices For Using Mucolytic Agents Including N-Acetyl Cysteine (NAC)
  申请人：Babu Uma Mahesh

  公开号：US20120258469A1

  公开（公告）日：2012-10-11

  Devices and methods incorporate mucolytic agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters one or more lysis agents and/or mucolytic agents. The mucolytic agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the mucolytic agent is localized between the sample application zone and the conjugate zone. In embodiments with a sample compressor, one or more mucolytic agents may be pre-loaded and dried on the sample compressor, the sample collector, in various locations on the test strip, or in the running buffer.
• Methods and Devices for Using Mucolytic Agents Including N-Acetyl Cysteine (NAC)
  申请人：Rapid Pathogen Screening, Inc.

  公开号：US20150323527A1

  公开（公告）日：2015-11-12

  Devices and methods incorporate mucolytic agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters one or more lysis agents and/or mucolytic agents. The mucolytic agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the mucolytic agent is localized between the sample application zone and the conjugate zone. In embodiments with a sample compressor, one or more mucolytic agents may be pre-loaded and dried on the sample compressor, the sample collector, in various locations on the test strip, or in the running buffer.
• METHODS AND DEVICES FOR USING MUCOLYTIC AGENTS INCLUDING N-ACETYL CYSTEINE (NAC)
  申请人：Rapid Pathogen Screening, Inc.

  公开号：US20210302419A1

  公开（公告）日：2021-09-30

  Devices and methods incorporate mucolytic agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters one or more lysis agents and/or mucolytic agents. The mucolytic agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the mucolytic agent is localized between the sample application zone and the conjugate zone. In embodiments with a sample compressor, one or more mucolytic agents may be pre-loaded and dried on the sample compressor, the sample collector, in various locations on the test strip, or in the running buffer.
• US9797898B2
  申请人：——

  公开号：US9797898B2

  公开（公告）日：2017-10-24