乙基-[2-[4-[2-(乙基-二甲基铵基)乙氧基]-4-氧代丁酰基]氧乙基]-二甲基铵二溴化物 | 111-00-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 乙基-[2-[4-[2-(乙基-二甲基铵基)乙氧基]-4-氧代丁酰基]氧乙基]-二甲基铵二溴化物
• 中文别名: 溴琥乙氧铵
• 英文名称: Suxethonium bromide
• 英文别名: ethyl-[2-[4-[2-[ethyl(dimethyl)azaniumyl]ethoxy]-4-oxobutanoyl]oxyethyl]-dimethylazanium;dibromide
• CAS: 111-00-2；63981-96-4
• 化学式: C16H34Br2N2O4
• 分子量: 478.3
• InChiKey: KTZFEWDRQPCZAP-UHFFFAOYSA-L

物化性质

• 熔点：
  158°

计算性质

• 辛醇/水分配系数(LogP)：
  -4.95
• 重原子数：
  24
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 海关编码：
  2923900090

文献信息

• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• Compositions and methods to effect the release profile in the transdermal administration of active agents
  申请人：——

  公开号：US20020004065A1

  公开（公告）日：2002-01-10

  Compositions and methods for the transdermal delivery of active agents up to a period of seven days or more at substantially a zero-order release rate comprising a pharmaceutically acceptable adhesive matrix and a polymeric plastic material that provides a release rate regulating effect on the active agents.

  本发明涉及一种用于经皮递送活性药剂的组合物和方法，该组合物和方法能够在持续时间为七天或更长时间内以几乎零阶释放速率递送活性药剂，包括一种药学上可接受的粘合基质和一种聚合物塑料材料，该聚合物塑料材料对活性药剂具有释放速率调节作用。
• Transdermal device containing polyvinylpyrrolidone as solubility enhancer
  申请人：NOVEN PHARMACEUTICALS, INC.

  公开号：EP1329225A2

  公开（公告）日：2003-07-23

  A blend of at least three polymers, including a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin. Soluble polyvinylpyrrolidone increases the solubility of drug without negatively affecting the adhesivity of the composition or the rate of drug delivery from the pressure-sensitive adhesive composition

  包括可溶性聚乙烯吡咯烷酮在内的至少三种聚合物与药物的混合物为透皮给药系统提供了一种压敏粘合剂组合物，当压敏粘合剂组合物与人体皮肤接触时，药物可从压敏粘合剂组合物中通过真皮输送。可溶性聚乙烯吡咯烷酮增加了药物的溶解度，而不会对组合物的粘附性或压敏胶组合物的给药速率产生负面影响。
• Transdermal drug delivery device including an occlusive backing
  申请人：Noven Pharmaceuticals, Inc.

  公开号：US10231938B2

  公开（公告）日：2019-03-19

  A transdermal drug delivery system for the topical application of one or more active agents contained in one or more polymeric and/or adhesive carrier layers, proximate to a non-drug containing polymeric backing layer which can control the delivery rate and profile of the transdermal drug delivery system by adjusting the moisture vapor transmission rate of the polymeric backing layer.

  一种透皮给药系统，用于局部应用一种或多种活性剂，这些活性剂包含在一个或多个聚合物和/或粘合剂载体层中，靠近一个不含药物的聚合物背层，该背层可通过调节聚合物背层的湿气透过率来控制透皮给药系统的给药速率和概况。
• Technology for preparation of macromolecular microspheres
  申请人：Ansun Biopharma, Inc.

  公开号：US10583086B2

  公开（公告）日：2020-03-10

  Microspheres are produced by contacting an aqueous solution of a protein or other macromolecule with an organic solvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions.

  微球是通过将蛋白质或其他大分子的水溶液与有机溶剂和反离子接触，然后将溶液冷却而制成的。微球可用于制备特定尺寸的药物。