乙基-氨基甲酸4-硝基苯基酯 | 17576-41-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 乙基-氨基甲酸4-硝基苯基酯
• 英文名称: 4-Nitrophenyl ethylcarbamate
• 英文别名: (4-nitrophenyl) N-ethylcarbamate
• CAS: 17576-41-9
• 化学式: C9H10N2O4
• mdl: MFCD01738228
• 分子量: 210.19
• InChiKey: QVUXGCDXMKCVSB-UHFFFAOYSA-N

物化性质

• 沸点：
  329.1±34.0 °C(Predicted)
• 密度：
  1.279±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2924299090
• 危险性防范说明：
  P264,P270,P301+P312,P330,P501
• 危险性描述：
  H302

文献信息

• Process for the preparation of an anticonvulsant compound
  申请人：Dipharma Francis S.r.l.

  公开号：EP2730560A1

  公开（公告）日：2014-05-14

  The invention provides a novel method for the preparation of intermediates useful in a process designed to obtain known 1,2,4-triaminobenzene compounds, and in particular a specific compound thereof having known anticonvulsant activity. Unlike known methods, the novel method does not require advance protection of the amino groups present on the substrate.

  该发明提供了一种新的方法，用于制备在旨在获得已知的1,2,4-三氨基苯化合物的过程中有用的中间体，特别是其中一种具有已知抗惊厥活性的特定化合物。与已知方法不同，这种新方法不需要提前保护底物上存在的氨基团。
• PROCESS FOR THE PREPARATION OF AN ANTICONVULSANT COMPOUND
  申请人：DIPHARMA FRANCIS S.r.I

  公开号：US20140163252A1

  公开（公告）日：2014-06-12

  The invention provides a novel method for the preparation of intermediates useful in a process designed to obtain known 1,2,4-triaminobenzene compounds, and in particular a specific compound thereof having known anticonvulsant activity. Unlike known methods, the novel method does not require advance protection of the amino groups present on the substrate.

  该发明提供了一种新颖的方法，用于制备在旨在获得已知的1,2,4-三氨基苯化合物的过程中有用的中间体，特别是其中一种具有已知抗惊厥活性的特定化合物。与已知方法不同，这种新颖方法不需要提前保护底物上存在的氨基团。
• [EN] SYNTHETIC PROCESS FOR THE MANUFACTURE OF ECTEINASCIDIN COMPOUNDS<br/>[FR] PROCÉDÉ DE SYNTHÈSE POUR LA PRÉPARATION DE COMPOSÉS ECTEINASCIDINES
  申请人：PHARMA MAR SA

  公开号：WO2011147828A1

  公开（公告）日：2011-12-01

  This invention relates to compounds of formula II: wherein R1, R2, ProtSH, and ProtNH are as defined, to processes for the synthesis of ectainascidins of formula I from compounds of formula II, and to processes for the synthesis of compounds of formula II.

  这项发明涉及到式子II的化合物：其中R1、R2、ProtSH和ProtNH的定义如下，以及从式子II的化合物合成式子I的ectainascidins的过程，以及合成式子II的化合物的过程。
• Anti-inflammatory medicaments
  申请人：Flynn Daniel L.

  公开号：US20080187978A1

  公开（公告）日：2008-08-07

  Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds.

  提供了治疗炎症病症的新化合物及其使用方法。在一种首选实施例中，调节p38激酶蛋白的激活状态包括将该激酶蛋白与新化合物接触。
• Thiadiazoline derivative
  申请人：Murakata Chikara

  公开号：US20070112044A1

  公开（公告）日：2007-05-17

  An antitumor agent comprising a thiadiazoline derivative represented by the general formula (I), or a pharmacologically acceptable salt thereof as an active ingredient: (wherein Z represents a sulfur atom and the like, R 1 represents substituted or unsubstituted lower alkynyl and the like, R 2 represents a hydrogen atom and the like, R 3 represents substituted or unsubstituted lower alkyl and the like, and R 4 represents substituted or unsubstituted aryl and the like), and the like are provided.

  一种抗肿瘤剂，包括由通式（I）表示的噻二唑衍生物或其药学上可接受的盐作为活性成分：（其中Z代表硫原子等，R1代表取代或未取代的较低炔基等，R2代表氢原子等，R3代表取代或未取代的较低烷基等，R4代表取代或未取代的芳基等）等。