2-[3-(4-Fluorophenoxy)propyl]guanidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[3-(4-Fluorophenoxy)propyl]guanidine
• 英文别名: 2-[3-(4-fluorophenoxy)propyl]guanidine
• 化学式: C₁₀H₁₄FN₃O
• 分子量: 211.24
• InChiKey: XOCPWOMPGUYXHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  73.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] METHODS OF MODULATING LEVELS OF IL-6 AND PD-L1<br/>[FR] MÉTHODES DE MODULATION DE NIVEAUX D'IL-6 ET DE PD-L1
  申请人：UNIV DREXEL

  公开号：WO2017106312A1

  公开（公告）日：2017-06-22

  Embodiments described herein provide methods of treating various diseases or disorders using Sigma1 modulating compounds alone or in combination with other therapeutic agents.
• [EN] METHODS FOR TREATING, AMELIORATING, OR PREVENTING VIRAL INFECTIONS<br/>[FR] MÉTHODES DE TRAITEMENT, D'AMÉLIORATION OU DE PRÉVENTION D'INFECTIONS VIRALES
  申请人：UNIV JEFFERSON

  公开号：WO2021202535A1

  公开（公告）日：2021-10-07

  The present disclosure relates to the finding that certain compounds that modulate the activity(ies) of Sigma receptors can be used to disrupt virus lifecycle, infection, and/or dissemination. The compounds contemplated in the disclosure are useful in the treatment or amelioration of virus infection, such as but not limited to coronavirus infection, either alone or in combination with at least one additional therapeutic agent, which can be an antiviral agent and/or an agent that treats, ameliorates, and/or prevents one or more virus infection symptoms or co-morbidities. In certain embodiments, the Sigma receptor is a Sigma-1 receptor (also known as Sigma1) or Sigma-2 receptor (also known as Sigma2 or TMEM97).