diphenyl(4-chlorophenyl)(phenylamino)methylphosphonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diphenyl(4-chlorophenyl)(phenylamino)methylphosphonate
• 英文别名: diphenyl [anilino(4-chlorophenyl)methyl]phosphonate；N-[(4-chlorophenyl)-diphenoxyphosphorylmethyl]aniline
• 化学式: C₂₅H₂₁ClNO₃P
• 分子量: 449.873
• InChiKey: VBYLFWCZCWFRBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异氰酸苯酯 、 alkaline earth salt of/the/ methylsulfuric acid 在 三乙胺 作用下， 以 二氯甲烷 、 xylene 为溶剂， 反应 6.0h， 生成 diphenyl(4-chlorophenyl)(phenylamino)methylphosphonate
  参考文献：
  名称：

  New One‐Pot Three‐Component Synthesis of N‐Phenyl α‐Aminophosphonates

  摘要：

  New one-pot three-component reactions employing aldehydes, triphenylphosphite, and N-[(phenylamino) carbonyl] glycine ethyl ester in refluxing xylene readily afford N- phenyl alpha-aminophosphonates in low to moderate yields.

  DOI：

  10.1080/00397910600941463

文献信息

• Zinc Di(l-prolinate)-Mediated Synthesis of α-Aminophosphonates under Mild Conditions
  作者：Nelson Domingues、Aline de Oliveira、Ramesh Katla、Mariana Rocha、Tábata Albuquerque、Caren da Silva、Vicente Kupfer、Andrelson Rinaldi

  DOI：10.1055/s-0036-1588065

  日期：——

  Abstract An efficient method has been developed for the preparation of α-aminophosphonates by using zinc di(l-prolinate) as a catalyst under mild reaction conditions. The method has the advantages of high yields, short reaction times, and easy workup conditions. An efficient method has been developed for the preparation of α-aminophosphonates by using zinc di(l-prolinate) as a catalyst under mild reaction

  摘要 已经开发出一种有效的方法，该方法通过在温和的反应条件下使用二（1-脯氨酸锌）锌作为催化剂来制备α-氨基膦酸酯。该方法具有收率高，反应时间短，后处理条件容易的优点。 已经开发出一种有效的方法，该方法通过在温和的反应条件下使用二（1-脯氨酸锌）锌作为催化剂来制备α-氨基膦酸酯。该方法具有收率高，反应时间短，后处理条件容易的优点。
• A new, efficient and recyclable [Ce(<scp>l</scp>-Pro)]₂(Oxa) heterogeneous catalyst used in the Kabachnik–Fields reaction
  作者：Caren D. G. da Silva、Aline R. Oliveira、Mariana P. D. Rocha、Ramesh Katla、Eriton Rodrigo Botero、Érica C. da Silva、Nelson Luís C. Domingues

  DOI：10.1039/c5ra27064b

  日期：——

  Herein we introduce a new catalyst for the Kabachnik–Fields reaction, [Ce(L-Pro)]2(Oxa), using a very accessible, simple and efficient methodology for α-aminophosphonate synthesis using an aromatic aldehyde, an aromatic amine and diphenyl phosphite. This procedure was developed using a low catalyst loading of cerium(III) prolinate and it has allowed for the recycling of the catalyst.

  本文中，我们介绍了一种用于Kabachnik-Fields反应的新催化剂[Ce（L -Pro）] 2（Oxa），它使用一种易于获得，简单且有效的方法来合成芳族醛，芳族胺和二苯基的α-氨基膦酸酯亚磷酸酯。该程序是使用低催化剂负载的脯氨酸铈（III）开发的，它可以循环使用催化剂。
• A Novel and Efficient Synthesis of α-Aminophosphonates by Use of Triphenyl Phosphite in Acetic Acid Media
  作者：Mohsen Rostamizadeh、Malek Taher Maghsoodlou、Nourallah Hazeri、Sayyed Mostafa Habibi-khorassani、Leila Keishams

  DOI：10.1080/10426507.2010.500641

  日期：2011.1.31

  Abstract For the first time, α-aminophosphonates were obtained by a simple and efficient one-pot method from the reaction between aldehyde, aniline, and triphenyl phosphite in the presence of acetic acid as a catalyst and solvent at room temperature. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements

  摘要 醛、苯胺和亚磷酸三苯酯在乙酸作为催化剂和溶剂的存在下，在室温下，通过简单高效的一锅法反应，首次获得了α-氨基膦酸酯。补充材料可用于本文。转至出版商在线版的磷、硫和硅及相关元素，查看免费的补充文件。图形概要
• Design and preparation of HPW-anchored magnetic carbon nitride nanosheets: an efficient and eco-friendly nanocomposite for one-pot synthesis of α-amino phosphonates
  作者：Asieh Azhdari、Najmedin Azizi

  DOI：10.1007/s11164-021-04545-0

  日期：2021.12

  biocompatibility and high performance. Herein, we introduce a novel nanocomposite comprising of different acids anchored to magnetic mesoporous carbon nitrides through a grindstone method to enhance nanocomposite catalysts’ environmentally benign capability. As a result, the obtained porous magnetic catalysts show the highest possible activity and product selectivity for facile preparation of α-amino phosphonates

  多相催化是学术研究人员和化学工业中发展最快和最大的分支之一，也是长期面临的挑战。具有各种官能团、最丰富的元素和天然产物中主要成分的碳基材料由于其优异的生物相容性和高性能为多相催化提供了独特的平台。在此，我们介绍了一种新型纳米复合材料，该复合材料包含通过磨石法锚定在磁性介孔氮化碳上的不同酸，以增强纳米复合催化剂的环境友好能力。因此，所获得的多孔磁性催化剂显示出最高的活性和产物选择性，可以在环境温度下以良好至极好的收率轻松制备 α-氨基膦酸酯衍生物。
• A Quick and Clean Procedure for Synthesis of<i>α</i>-Aminophosphonates in Aqueous Media
  作者：Ebrahim Mollashahi、Hamideh Gholami、Mehrnoosh Kangani、Mojtaba Lashkari、Malek Taher Maghsoodlou

  DOI：10.1002/hc.21263

  日期：2015.9

  A green and efficient procedure for the synthesis of α-aminophosphonates has been developed in water as a green and nonhazardous solvent, from condensation between aromatic aldehydes, aniline, and triphenyl phosphite at 80°C. This methodology has a number of advantages including clean reaction conditions, easy work-up, and environmentally friendly.

  在 80°C 下，芳香醛、苯胺和亚磷酸三苯酯缩合，在水中作为绿色无害溶剂开发了一种绿色高效的合成 α-氨基膦酸酯的方法。这种方法具有许多优点，包括清洁的反应条件、易于处理和环境友好。