4-chlorobutyl 2-chloronicotinate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-chlorobutyl 2-chloronicotinate
• 英文别名: 4-chlorobutyl 2-chloropyridine-3-carboxylate
• 化学式: C₁₀H₁₁Cl₂NO₂
• 分子量: 248.109
• InChiKey: WWUFLGVMGXXDFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  四氢呋喃 、 2-氯烟酰氯 在 bismuth (III) nitrate pentahydrate 作用下， 以92%的产率得到4-chlorobutyl 2-chloronicotinate
  参考文献：
  名称：

  A mild and efficient synthesis of chloroesters by the cleavage of cyclic and acyclic ethers using Bi(NO₃)₃·5H₂O as a catalyst under solvent-free conditions

  摘要：

  本文介绍了一种简便、高效的氯酯合成方法。在无溶剂条件下，环状和非环状醚与酸性氯化物在催化量 Bi(NO3)3-5H2O 的存在下发生反应，生成相应的氯酯。此外，催化剂可以方便地回收并有效地重复使用至少六次：五水硝酸铋（III） 环醚和无环醚 氯酯

  DOI：

  10.1139/v07-126

文献信息

• A mild and efficient synthesis of chloroesters by the cleavage of cyclic and acyclic ethers using Bi(NO₃)₃·5H₂O as a catalyst under solvent-free conditions
  作者：V Suresh、N Suryakiran、Y Venkateswarlu

  DOI：10.1139/v07-126

  日期：2007.12.1

  A facile, efficient synthesis of chloroesters is described. The reaction of cyclic and acyclic ethers with acid chlorides in the presence of catalytic amounts of Bi(NO₃)₃·5H₂O under solvent-free conditions yielded the corresponding chloroesters. Also, the catalyst can be recovered conveniently and reused efficiently for at least six times.Key words: Bismuth(III) nitrate pentahydrate, cyclic and acyclic ethers, chloroesters.

  本文介绍了一种简便、高效的氯酯合成方法。在无溶剂条件下，环状和非环状醚与酸性氯化物在催化量 Bi(NO3)3-5H2O 的存在下发生反应，生成相应的氯酯。此外，催化剂可以方便地回收并有效地重复使用至少六次：五水硝酸铋（III） 环醚和无环醚 氯酯
• Synthesis of Chloroesters by the Cleavage of Cyclic and Acyclic Ethers using La(NO₃)₃ · 6H₂O as a Mild and Efficient Catalyst under Solvent‐Free Conditions
  作者：V. Suresh、N. Suryakiran、K. Rajesh、J. Jon Paul Selvam、M. Srinivasulu、Y. Venkateswarlu

  DOI：10.1080/00397910701649403

  日期：2007.12.1

  A mild and an efficient synthesis of chloroesters is described by the reaction of cyclic and acyclic ethers with acid chlorides in the presence of a catalytic amount of La(NO3)(3)center dot 6H(2)O under solvent-free conditions, affording the corresponding chloroesters in excellent yields.
• Synthesis of chloroesters by the reaction of ethers with acyl chlorides catalyzed by ZnO
  作者：Yuqi Tang、Chengliang Feng、Wanfeng Yang、Min Ji、Wei Wang、Junqing Chen

  DOI：10.1007/s11696-020-01267-2

  日期：2021.1

  An efficient method for the synthesis of chloroesters by the reaction of ethers with acyl chlorides catalyzed by nano-ZnO under solvent-free condition at room temperature was described. The method is compatible with a range of ethers including tricyclic ethers, tetracyclic ethers, pentacyclic ethers and hexacyclic ethers and have afforded the products with moderate to good yields. The ZnO could be

  介绍了一种在室温无溶剂条件下，在纳米ZnO催化下，醚与酰氯反应合成氯代酯的有效方法。该方法与包括三环醚、四环醚、五环醚和六环醚在内的一系列醚相容，并以中等至良好的收率提供了产物。ZnO最多可重复使用3次，3次循环后产品收率为87%。