2-(4-isopropylphenyl)-1H-imidazo[4,5-b]phenazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(4-isopropylphenyl)-1H-imidazo[4,5-b]phenazine
• 英文别名: 2-(4-propan-2-ylphenyl)-1H-imidazo[4,5-b]phenazine
• 化学式: C₂₂H₁₈N₄
• 分子量: 338.412
• InChiKey: UGNPKZIGCJSLIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.45
• 重原子数：
  26.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  54.46
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  2,3-二氨基吩嗪 、 4-异丙基苯甲醛 在 硝基苯 作用下， 反应 8.0h， 以78%的产率得到2-(4-isopropylphenyl)-1H-imidazo[4,5-b]phenazine
  参考文献：
  名称：

  On the Synthesis of Pyrazino[2,3-b]phenazine and 1H-Imidazo[4,5-b]phenazine Derivatives

  摘要：

  Several pyrazino[2,3-D]phenazine derivatives were prepared by the reaction of 2,3-diaminophenazine with different 1,2-diketones. Nucleophilic substitution of 2,3-dibromomethyl-pyrazino[2,3-b]phenazine with propanol, morpholine, and potassium thiocyanate gave 2,3-bis(propoxymethyl)-pyrazino[2,3-b]phenazine 2,3-bis-(4-morpholinylmethyl)-pyrazino[2,3-b]phenazine, and 2,3-bis-(cyanosulfanylmethyl)-pyrazino[2,3-b]phenazine. 2-Aryl-1H-imidazo[4,5-b]phenazine derivatives were synthesized by a one-pot reaction of 1,3-diaminophenazine with different aromatic aldehydes or acids. Reaction of 2,3-diaminophenazine with acetic anhydride and formic acid afforded 1H-imidazo[4,5-b]phenazine and 2-methyl-1H-imidazo[4,5-b]phenazine. Chemical and spectroscopic evidences for the product structures of the new compounds are presented.

  DOI：

  10.1007/pl00010183

文献信息

• SLUKA, J.;ZIKAN, V.;DANEK, J., CS. FARM, 37,(1988) N 2, 65-70
  作者：SLUKA, J.、ZIKAN, V.、DANEK, J.

  DOI：——

  日期：——