3-benzylpentan-3-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-benzylpentan-3-amine
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: ZZUKQFJVCKOYSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-benzylpentan-3-amine 在 tris-(dibenzylideneacetone)dipalladium(0) 、 dipotassium hydrogenphosphate 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 生成 butyl 2-(3,3-diethyl-2,4-dihydro-1H-isoquinolin-1-yl)acetate
  参考文献：
  名称：

  通过Pd（II）催化的NH2定向将Michael受体插入C–H键中，然后进行NH2偶联的加成反应，制备取代的四氢异喹啉

  摘要：

  3,3-Disubstituted tetrahydroisoquinolines are prepared in one step from Michael acceptors and 2-phenylethylamines under Pd catalysis and Ag2CO3 as an oxidant. Presumably, activation of an ortho C-H bond of the aromatic ring with Pd(II) is directed by the primary amine to form a palladacycle. Insertion of the olefin, subsequent conjugated addition of the amine, and reductive elimination of Pd(0) affords the expected products. Silver carbonate is not necessary when 2-phenylethylamines are converted previously to N-benzoyloxy-2-phenylethylamines.

  DOI：

  10.1021/acs.organomet.6b00944
• 作为产物：
  描述：

  2-ethyl-2-benzyl-butyric acid amide 在 盐酸 、 alkaline aqueous potassium hypobromite 作用下， 生成 3-benzylpentan-3-amine
  参考文献：
  名称：

  Mentzer; Buu-Hoi; Cagniant, Bulletin de la Societe Chimique de France, 1942, vol. <5> 9, p. 813,816

  摘要：

  DOI：

文献信息

• New and easy route to primary cyclopropylamines from nitriles
  作者：Philippe Bertus、Jan Szymoniak

  DOI：10.1039/b105293b

  日期：——

  Starting from readily available substrates, we have developed a new synthesis of primary cyclopropylamines. The reaction involves a cooperative Ti(II)- and Lewis acid-mediated coupling of alkanenitriles with Grignard reagents.

  从容易获得的底物开始，我们开发了伯环丙胺的新合成方法。该反应涉及烷基钛与格氏试剂的Ti（II）-和路易斯酸介导的偶联偶联。
• Method for producing hematopoietic stem cells using pyrazole compounds
  申请人：Nishino Taito

  公开号：US09212348B2

  公开（公告）日：2015-12-15

  An expanding agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful as a therapy for various hematopoietic diseases and useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy is provided. A method of producing hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises expanding hematopoietic stem cells by culturing hematopoietic stem cells ex vivo in the presence of a compound represented by the formula following (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof (wherein R1 to R8 are as defined in the description).

  提供一种用于治疗各种造血系统疾病的造血干细胞和/或造血祖细胞的扩增剂，并用于提高基因转移效率以进行基因治疗。提供一种生产造血干细胞和/或造血祖细胞的方法，包括通过在存在以下式(I)所代表的化合物的情况下将造血干细胞在体外培养来扩增造血干细胞，该化合物的互变异构体或药用盐或其溶剂（其中R1至R8如描述中所定义）。
• PYRAZOLE COMPOUNDS HAVING THERAPEUTIC EFFECT ON MULTIPLE MYELOMA
  申请人：Nishino Taito

  公开号：US20130253204A1

  公开（公告）日：2013-09-26

  Novel therapeutic agents for myeloma are provided. A therapeutic agent for multiple myeloma containing a pyrazole compound represented by the formula (1): wherein R 1 is C 1 -C 6 alkyl, C 1 -C 6 alkyl substituted with R 17 , C 1 -C 6 haloalkyl, phenyl, phenyl substituted with a R 11 's or the like, R 2 is a hydrogen atom, C 1 -C 6 alkyl, phenyl or phenyl optionally substituted with e R 21 's or the like, R 3 is a hydrogen atom or the like, X is a single bond or —(CR 6 , R 7 ) n —, each of R 4 and R 5 is independently C 1 -C 6 alkyl or the like, R 6 and R 7 are hydrogen atoms or C 1 -C 6 alkyl, R 8 is phenyl, phenyl optionally substituted with k R 81 's or the like, a tautomer of the compound or a pharmaceutically acceptable salt or solvate thereof, as an active ingredient.

  提供了用于骨髓瘤的新型治疗药物。一种用于多发性骨髓瘤的治疗剂，包含由式（1）表示的吡唑烷化合物：其中R1是C1-C6烷基，C1-C6烷基取代为R17，C1-C6卤代烷基，苯基，苯基取代为R11或类似物，R2是氢原子，C1-C6烷基，苯基或可选地取代为e个R21或类似物，R3是氢原子或类似物，X是单键或—（CR6，R7)n—，R4和R5分别独立地是C1-C6烷基或类似物，R6和R7是氢原子或C1-C6烷基，R8是苯基，苯基可选地取代为k个R81或类似物，所述化合物的互变异构体或其药用上可接受的盐或溶剂，作为活性成分。
• Access to indolines from primary phenylethylamines by an unexpected palladium-catalyzed C–H functionalization process
  作者：Andrea Mancinelli、Joan Albert、Xavier Ariza、Leoní A. Barrios、Jordi Garcia、Roberto Gómez、Jaume Granell

  DOI：10.1039/c9ra05670j

  日期：——

  A new method for the preparation of 2,2-disubstituted indolines from 2-phenylethylamines was developed under Pd catalysis and PhI(OAc)2 as oxidant. Imines derived from 2-pyridinecarboxaldehyde were formed in situ to direct a C–H activation process. The resulting imines were also oxidized to the corresponding amides in the same Pd-catalyzed process to obtain the final indoline as a picolinamide.

  建立了Pd催化、PhI(OAc) 2为氧化剂、2-苯乙胺制备2,2-二取代二氢吲哚的新方法。由 2-吡啶甲醛衍生的亚胺原位形成，以指导 C-H 活化过程。所得亚胺也在相同的 Pd 催化过程中被氧化成相应的酰胺，以获得最终的二氢吲哚吡啶酰胺。
• Fluorine-Containing Compound, Fluorine-Containing Polymer Compound, Resist Composition and Patterning Method Using Same
  申请人：Mori Kazunori

  公开号：US20110318542A1

  公开（公告）日：2011-12-29

  There is disclosed a fluorine-containing polymer compound comprising a repeating unit (a) of the following general formula (2) and having a weight-average molecular weight of 1000 to 1000000 where R 1 represents a polymerizable double bond-containing group; R 2 represents a fluorine atom or a fluorine-containing alkyl group; R 3 represents a hydrogen atom, an acid labile group, a cross-linking site or the other monovalent organic group; and W 1 represents a linking moiety. When the fluorine-containing polymer compound is used in a resist compound for pattern formation by high energy radiation of 300 nm or less wavelength or electron beam radiation, it is possible to form a resist pattern with a good rectangular profile.

  本发明公开了一种含氟聚合物化合物，其包括下述通式（2）的重复单元（a），并且具有1000至1000000的重均分子量，其中R1表示聚合双键含有基团；R2表示氟原子或含氟烷基；R3表示氢原子、酸敏基团、交联位点或其他一价有机基团；W1表示连接基。当将该含氟聚合物化合物用于300纳米或更短波长的高能辐射或电子束辐射的图案形成的光阻化合物中时，可以形成具有良好矩形轮廓的光阻图案。