4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-2-methylphenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-2-methylphenol
• 英文别名: 2-methyl-4(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)phenol；4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-methylphenol
• 化学式: C₁₀H₈F₆O₂
• 分子量: 274.163
• InChiKey: MUWUWWPOGHFRDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  邻甲酚 、 六氟丙酮 在 N-甲基吗啉 作用下， 以 苯 为溶剂， 反应 1.0h， 以83.9%的产率得到4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-2-methylphenol
  参考文献：
  名称：

  Dyachenko, V. I.; Kolomiets, A. F.; Fokin, A. V., Journal of Organic Chemistry USSR (English Translation), 1992, vol. 28, # 8.2, p. 1345 - 1350

  摘要：

  DOI：

文献信息

• Fluorinated monophenols and diphenols and method for their preparation
  申请人：General Electric Company

  公开号：US04358624A1

  公开（公告）日：1982-11-09

  Phenol reactants and fluorinated aldehydes or fluorinated ketones are reacted in the presence of organic sulfonic acid catalysts to yield fluorinated monophenols and fluorinated diphenols. Fluorinated monophenols can be isolated and reacted with additional phenol reactant in the presence of organic sulfonic acid catalysts to yield asymmetrical, as well as symmetrical, fluorinated diphenols. A preferred organic sulfonic acid catalyst is methanesulfonic acid. The novel fluorinated monophenols have a hydroxy group and a fluorinated aryl radical or fluorinated alkyl radical substituted upon the benzylic carbon atom. The novel fluorinated diphenols have at least one fluorinated aryl radical or fluorinated alkyl radical substituted upon the methylene carbon atom of the bisphenol.

  苯酚反应物和氟代醛或氟代酮在有机磺酸催化剂存在下反应，生成氟代单苯酚和氟代二苯酚。氟代单苯酚可以被分离并与额外的苯酚反应物在有机磺酸催化剂存在下反应，生成不对称和对称的氟代二苯酚。首选的有机磺酸催化剂是甲磺酸。新型的氟代单苯酚在苯基碳原子上有一个羟基和一个氟代芳基基团或氟代烷基基团取代。新型的氟代二苯酚在双酚的亚甲基碳原子上至少有一个氟代芳基基团或氟代烷基基团取代。
• FLUORINATED MONOPHENOLS AND DIPHENOLS AND METHOD FOR THEIR PREPARATION
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0067851A1

  公开（公告）日：1982-12-29
• EP0067851A4
  申请人：——

  公开号：EP0067851A4

  公开（公告）日：1983-06-09
• Novolak Resin Containing Hexafluoroisopropanol Group, Method for Producing Same, and Composition of Same
  申请人：CENTRAL GLASS COMPANY, LIMITED

  公开号：US20150337077A1

  公开（公告）日：2015-11-26

  Disclosed is a novolak resin containing a repeating unit represented by the general formula (1). R 1 is a hydrogen atom or an alkyl group which is C 1-4 straight-chain or C 3-4 branched-chain, and some or all hydrogen atoms in the alkyl group may be replaced with a fluorine atom; R 2 is a hydrogen atom, a phenyl group, an alkyl group which is C 1-10 straight-chain or C 3-10 branched-chain, or an alkyl group having a C 3-10 cyclic structure, and some or all hydrogen atoms in the phenyl group and the alkyl group may be replaced with fluorine atoms; each of a and b is independently an integer of 1-3, and these are defined as 2≦a+b≦4; and d is an integer of 0-2. This novolak resin has high dissolution rate in the alkaline development solution in addition to the heat resisting property which is a property of phenolic resin.
• US4358624A
  申请人：——

  公开号：US4358624A

  公开（公告）日：1982-11-09