cremaphenanthrene O

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: cremaphenanthrene O
• 化学式: C₂₉H₃₀O₁₁
• 分子量: 554.551
• InChiKey: JPOARHPUBOPJLO-LILOYGOGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  40.0
• 可旋转键数：
  7.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  178.53
• 氢给体数：
  7.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  cremaphenanthrene O 在 水 、 三氟乙酸 作用下， 以 乙醇 为溶剂， 反应 8.0h， 生成 葡萄糖
  参考文献：
  名称：

  Five new benzylphenanthrenes from Cremastra appendiculata

  摘要：

  Five new benzylphenanthrenes, cremaphenanthrenes L-P (1-5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1-5 were tested in vitro for their cytotoxic effects against colon (HCT-116), cervix (Hela), and breast (MCF-7 and MDA-MB-231) cancer cell lines. Compound 1 showed moderate cytotoxic activities against HCT-116, MCF-7, and MDA-MB-231 cancer cell lines with IC50 values ranging from 15.84 to 24.18 mu M and weak cytotoxicity to Hela cell line with IC50 value of 68.81 mu M. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.fitote.2015.03.003

文献信息

• Five new benzylphenanthrenes from Cremastra appendiculata
  作者：Liang Liu、Jun Li、Ke-Wu Zeng、Yong Jiang、Peng-Fei Tu

  DOI：10.1016/j.fitote.2015.03.003

  日期：2015.6

  Five new benzylphenanthrenes, cremaphenanthrenes L-P (1-5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1-5 were tested in vitro for their cytotoxic effects against colon (HCT-116), cervix (Hela), and breast (MCF-7 and MDA-MB-231) cancer cell lines. Compound 1 showed moderate cytotoxic activities against HCT-116, MCF-7, and MDA-MB-231 cancer cell lines with IC50 values ranging from 15.84 to 24.18 mu M and weak cytotoxicity to Hela cell line with IC50 value of 68.81 mu M. (C) 2015 Elsevier B.V. All rights reserved.