DL-[2,3,3-2H3]glutamic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DL-[2,3,3-2H3]glutamic acid
• 英文别名: 2-Amino-2,3,3-trideuteriopentanedioic acid
• 化学式: C₅H₉NO₄
• 分子量: 150.107
• InChiKey: WHUUTDBJXJRKMK-GWYZVRNTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  alpha-酮戊二酸 在 palladium on activated charcoal 吡啶 、 氯化铵-d4 、 水 、 sodium acetate 、 peroxyformic acid 作用下， 生成 DL-[2,3,3-2H3]glutamic acid
  参考文献：
  名称：

  Non-fatty acyl polyketide starter in the biosynthesis of vicenistatin, an antitumor macrolactam antibiotic

  摘要：

  A biosynthetic pathway of an antitumor antibiotic vicenistatin was investigated by feeding experiments of [1-C-13] and [1,2-C-13(2)]acetate, [1-C-13]propionate, [2,3,3-H-2(3)]glutamate, and D-[6,6-H-2(2)]glucose. The elongating units of the aglycon of vicenistatin are derived from standard acetate-propionate, whereas the starter unit appears to be derived from a 3-amino-2-methylpropionate equivalent through the glutamate mutase reaction. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00455-9

文献信息

• Non-fatty acyl polyketide starter in the biosynthesis of vicenistatin, an antitumor macrolactam antibiotic
  作者：Miyuki Otsuka、Tadashi Eguchi、Kazutoshi Shindo、Katsumi Kakinuma

  DOI：10.1016/s0040-4039(98)00455-9

  日期：1998.5

  A biosynthetic pathway of an antitumor antibiotic vicenistatin was investigated by feeding experiments of [1-C-13] and [1,2-C-13(2)]acetate, [1-C-13]propionate, [2,3,3-H-2(3)]glutamate, and D-[6,6-H-2(2)]glucose. The elongating units of the aglycon of vicenistatin are derived from standard acetate-propionate, whereas the starter unit appears to be derived from a 3-amino-2-methylpropionate equivalent through the glutamate mutase reaction. (C) 1998 Elsevier Science Ltd. All rights reserved.