Tfa-aspartic anhydride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Tfa-aspartic anhydride
• 英文别名: (R,S)-N-trifluoroacetylaspartic anhydride；α-trifluoroacetylaminosuccinic anhydride；trifluoroacetylaspartic anhydride；N-trifluoroacetyl-aspartic Anhydride；(R,S)-trifluoroacetyl-aspartic Anhydride；4-[3-Carboxy-2-[(2,2,2-trifluoroacetyl)amino]propanoyl]oxy-4-oxo-3-[(2,2,2-trifluoroacetyl)amino]butanoic acid
• 化学式: C₁₂H₁₀F₆N₂O₉
• 分子量: 440.21
• InChiKey: JRBGCPAGBWBYSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  176
• 氢给体数：
  4
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  Tfa-aspartic anhydride 、 邻二氯苯 在 三氯化铝 盐酸 作用下， 以 正己烷 、 水 为溶剂， 生成 N-trifluoroacetyl-2-amino-4-oxo-4-(3',4'-dichlorophenyl)-butanoic acid
  参考文献：
  名称：

  N-substituted-2-amino-4-phenyl-4-oxo-butanoic acid compounds having kynurenine-3-hydroxy base inhibitory activity

  摘要：

  一种具有如下化学式(I)的N-取代-2-氨基-4-苯基-4-氧代丁酸化合物：其中X、Y、W和R的定义如本文所述。

  公开号：

  US06207709B1

文献信息

• Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity
  申请人：——

  公开号：US20030195257A1

  公开（公告）日：2003-10-16

  Formula (I) compounds are described, where the groups are defined in the description, as well as processes for their preparation and their use as medicaments, particularly as selective phosphodiesterase IV inhibitors. 1

  描述了Formula (I)化合物，其中群在描述中定义，以及它们的制备过程和用途，特别是作为选择性磷酸二酯酶IV抑制剂的药物。
• Substituted piperidines, medicaments containing these compounds, and methods for the production thereof
  申请人：——

  公开号：US20030212057A1

  公开（公告）日：2003-11-13

  The present invention relates to substituted piperidines of general formula 1 wherein A 1 , A 2 , R, R 1 and R 2 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

  本发明涉及通式1中的取代哌啶，其中A1，A2，R，R1和R2的定义如权利要求书1中所述，其互变异构体，对映异构体，混合物和盐，特别是与无机或有机酸或碱的生理上可接受的盐，具有有价值的药理学特性，特别是CGRP-拮抗特性，含有这些化合物的制药组合物，它们的用途和制备它们的方法。
• Fungicidal 3-(N-carbonylamino)-pyrrolidine-2,5-diones
  申请人：Ciba-Geigy Corporation

  公开号：US04332816A1

  公开（公告）日：1982-06-01

  Novel compounds of the formula ##STR1## wherein R.sub.1 is chlorine, bromine or nitro, R.sub.2 is chlorine or bromine, R.sub.3 is hydrogen or fluorine, R.sub.4 is C.sub.1 -C.sub.9 alkyl which is unsubstituted or substituted by halogen or C.sub.1 -C.sub.3 alkoxy, or is C.sub.2 -C.sub.7 alkenyl, C.sub.2 -C.sub.4 alkynyl or C.sub.3 -C.sub.6 cycloalkyl, each of which is unsubstituted or substituted by halogen or aryl, or is phenyl which is unsubstituted or substituted by halogen, nitro or C.sub.1 -C.sub.4 alkyl, or is a 5-membered heterocyclic ring system which contains a hetero-atom, or is X-R.sub.5, wherein X is oxygen or sulfur and R.sub.5 is C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.6 alkenyl, each of which is unsubstituted or substituted by halogen or C.sub.1 -C.sub.3 alkoxy, or is phenyl which is unsubstituted or substituted by halogen, nitro, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy, or is benzyl which is unsubstituted or substituted by halogen or nitro. These compounds possess useful microbicidal properties and can be used for controlling phytopathogenic microorganisms, especially phytopathogenic fungi. They have, for practical purposes, a very advantageous curative, preventive and systemic action for protecting cultivated plants, without adversely affecting these by undesirable side-effects.

  化合物的结构式为##STR1##其中R.sub.1是氯、溴或硝基，R.sub.2是氯或溴，R.sub.3是氢或氟，R.sub.4是未取代或取代卤素或C.sub.1-C.sub.3烷氧基的C.sub.1-C.sub.9烷基，或未取代或取代卤素或芳基的C.sub.2-C.sub.7烯基，C.sub.2-C.sub.4炔基或C.sub.3-C.sub.6环烷基，或未取代或取代卤素、芳基或C.sub.1-C.sub.4烷基的未取代或取代苯基，或含有杂原子的5元杂环烷基，或是X-R.sub.5，其中X为氧或硫，R.sub.5是未取代或取代卤素或C.sub.1-C.sub.3烷氧基的C.sub.1-C.sub.6烷基或C.sub.3-C.sub.6烯基，或未取代或取代卤素、芳基、C.sub.1-C.sub.3烷基或C.sub.1-C.sub.3烷氧基的未取代或取代苯基，或未取代或取代卤素或硝基的未取代或取代苄基。这些化合物具有有用的杀菌性质，可用于控制植物病原微生物，特别是植物病原真菌。它们具有非常有利的治疗、预防和系统作用，可以保护耕种植物，而不会对其产生不良的副作用。
• Fluoro-substituted benzoylpropionic acid derivatives
  申请人：Pharmacia & Upjohn S.p.A.

  公开号：US05973006A1

  公开（公告）日：1999-10-26

  A fluoro-substituted benzoylpropionic acid compound of formula (I) either as a single optical isomer or as a mixture of optical isomers ##STR1## wherein R is hydroxy, amino, hydroxylamine, --OR', --NHR', N(R').sub.2 or --NHOR' in which R' is C.sub.1 -C.sub.6 alkyl or benzyl; or a pharmaceutically acceptable salt thereof.

  一种氟代苯甲酰丙酸衍生物化合物，其化学式为（I），可以是单一的光学异构体或光学异构体混合物，其中R为羟基，氨基，羟胺，-OR'，-NHR'，N（R'）2或-NHOR'，其中R'为C1-C6烷基或苄基；或其药学上可接受的盐。
• [EN] 2-AMINOTETRALINES, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS, FOR THE PREVENTION AND THERAPEUTIC TREATMENT OF INFLAMMATORY AND/OR AUTOIMMUNE PATHOLOGIES<br/>[FR] 2-AMINOTETRALINES, LEUR PROCEDE DE PREPARATION, ET COMPOSITIONS PHARMACEUTIQUES POUR LA PREVENTION ET LE TRAITEMENT THERAPEUTIQUE DE PATHOLOGIES INFLAMMATOIRES ET/OU AUTO-IMMUNES
  申请人：SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.

  公开号：WO1999015494A1

  公开（公告）日：1999-04-01

  (EN) 2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopathogenic role of inflammatory cytokines has been ascertained.(FR) La présente invention concerne des 2-aminotétralines, leur procédé de préparation, et des compositions pharmaceutiques pour la prévention et le traitement thérapeutique de pathologies inflammatoires (en particulier le choc septique) et/ou auto-immunes dans lesquelles on a constaté le rôle étiopathogène des cytokines inflammatoires.

  该发明涉及2-氨基间甲酰胺、它们的制备方法以及用于预防和治疗炎症病变（尤其是急性脓毒症）和/或自身免疫性疾病药物制剂的药物，这些疾病尤其以炎症介导的因素为特征。