Benzyl 2,5-diacetoxybenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzyl 2,5-diacetoxybenzoic acid
• 英文别名: 2,5-Diacetyloxy-3-benzylbenzoic acid
• 化学式: C₁₈H₁₆O₆
• 分子量: 328.321
• InChiKey: KXLMYOMYMQMPJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  乙醚 、 2,5-二羟基苯甲酸 、 溴甲苯 在 吡啶 、 盐酸 、 乙酸酐 、 三乙胺 作用下， 以 水 、 乙腈 为溶剂， 以80%的产率得到Benzyl 2,5-diacetoxybenzoic acid
  参考文献：
  名称：

  Analgesic and anti-inflammatory compounds and compositions containing

  摘要：

  二羟基苯甲酸衍生物和含有它们的组合物可用于局部涂抹到皮肤上，也可用于全身给药。这些化合物特别有效地提供镇痛、退热和抗炎效果。

  公开号：

  US04276430A1

文献信息

• Process for preparing acylated esters of hydroxy carboxylates
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0002872A1

  公开（公告）日：1979-07-11

  A process for esterifying and acylating hydroxycarboxylate compounds in an organonitrile reaction medicine comprising the steps of contacting said compounds with an esterification agent-and thereafter acylating by adding an acylating agent to the reaction medium.

  一种在有机腈反应药剂中对羟基羧酸化合物进行酯化和酰化的工艺，包括以下步骤：将所述化合物与酯化剂接触，然后通过向反应介质中添加酰化剂进行酰化。
• Penetrating topical pharmaceutical compositions
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0043738A2

  公开（公告）日：1982-01-13

  A large group of lipophilic, pharmacologically active compounds can be effectively delivered across intact skin by applying them topically in a binary, penetration-enhancing vehicle containing (1) a C3-C4 diol, diol ester, or diol ether and (2) a cell envelopedisordering compound. This vehicle provides surprising enhancement of skin penetration for the pharmacological active, compared to either component alone.

  通过将一大类亲油性药理活性化合物置于一种二元渗透增强载体中进行局部涂抹，可以有效地在完整皮肤上传递这些化合物，该载体包含（1）C3-C4 二醇、二醇酯或二醇醚和（2）细胞包膜异序化合物。与单独使用其中任何一种成分相比，这种载体能惊人地增强药理活性成分的皮肤渗透性。
• Emollient-containing skin conditioning compositions
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0103910A1

  公开（公告）日：1984-03-28

  Skin conditioning compositions are described which comprise an emulsion of petrolatum; water; an unsaturated monoglyceride emulsifier; and a skin conditioning agent, preferably glycerine. As a result of the novel cubic, viscous isotropic dispersed phase of these water-in-oil emulsions, they possess the ability to incorporate and deliver relatively high levels of glycerine while retaining high cosmetic acceptance.

  所述的皮肤调理组合物由凡士林油乳液、水、不饱和单甘油酯乳化剂和皮肤调理剂（最好是甘油）组成。由于这些油包水型乳液具有新颖的立方体、粘性各向同性分散相，因此能够掺入并提供相对较高的甘油含量，同时保持较高的化妆品接受度。
• Emollient-containing topical pharmaceutical compositions
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0103911A1

  公开（公告）日：1984-03-28

  Topical pharmaceutical compositions are described which comprise an emulsion of petrolatum; water; an unsaturated monoglyceride emulsifier; and a pharmaceutical agent. The dispersed phase of these water-in oil emulsions exists in a cubic, viscous isotropic phase. These compositions are useful for delivery of a large group of pharmaceutical agents through the skin for local and/or systemic action.

  本文描述了由凡士林油乳液、水、不饱和单甘酯乳化剂和药剂组成的外用药物组合物。 这些油包水型乳液的分散相为立方体粘稠各向同性相。 这些组合物可用于通过皮肤输送大量药剂，以发挥局部和/或全身作用。
• Improved penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0129284A2

  公开（公告）日：1984-12-27

  Improved topical pharmaceutical compositions containing a pharmaceutically-active agent and the penetration enhancing agent 1-dodecylazacycloheptan-2-one are disclosed. This agent is used at selected levels in combination with certain C3-C4 diols or a 1-substituted azacycloalkyl-2-one. This composition provides marked transepidermal and percutaneous delivery of the selected pharmaceutically-active agent. A method of treating certain pathologies and conditions responsive to the selected active, systemically or locally, is also disclosed.

  本发明公开了含有一种药物活性剂和渗透增强剂 1-十二烷基氮杂环庚烷-2-酮的改良外用药物组合物。这种药剂与某些 C3-C4 二醇或 1-取代偶氮环烷基-2-酮结合使用时，可达到选定的水平。这种组合物能明显地经皮和经皮给药。此外，还公开了一种全身或局部治疗对所选活性剂有反应的某些病理和病症的方法。