homoplatensimide A

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: homoplatensimide A
• 英文别名: (2S)-5-amino-2-[[(E)-5-[(1S,5S,6S,7S,9S)-5,9-dimethyl-4-oxo-8-oxatetracyclo[7.2.1.17,10.01,6]tridec-2-en-5-yl]-2-methylpent-2-enoyl]amino]-5-oxopentanoic acid
• 化学式: C₂₅H₃₄N₂O₆
• 分子量: 458.555
• InChiKey: LSLTZMQPHAAWAW-TVJMVYBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  homoplatensimide A 在 盐酸 作用下， 反应 15.0h， 生成 L-谷氨酸
  参考文献：
  名称：

  Structure of homoplatensimide A: a potential key biosynthetic intermediate of platensimycin isolated from Streptomyces platensis

  摘要：

  Platensimycin and platencin are novel natural product antibiotics that inhibit bacterial growth by inhibiting fatty acid biosynthesis enzymes FabF and FabF/FabH, respectively. Continued search for the natural congeners for structure activity relationship studies led to the isolation of a congener which possesses all of the twenty carbons of diterpenoid unit, a potential biosynthetic intermediate of platensic acid unit of platensimycin. Isolation, structure, and activity of homoplatensimide A and biosynthetic relationship to platensimycin have been described. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2008.03.155