2-(4-methylbenzyl)phloroglucinol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-methylbenzyl)phloroglucinol
• 英文别名: 2-[(4-Methylphenyl)methyl]benzene-1,3,5-triol
• 化学式: C₁₄H₁₄O₃
• 分子量: 230.263
• InChiKey: KWTBQAOOTRHRFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  尿苷(5')二氢二磷酰(1)-alpha-D-葡萄糖 、 2-(4-methylbenzyl)phloroglucinol 在 glycosyltransferase AbGT₇₃ pure enzyme 作用下， 反应 24.0h， 以88%的产率得到3-C-β-D-glucosyl-1-(4-methylbenzyl)benzene-2,4,6-triol
  参考文献：
  名称：

  一类碳糖苷类化合物及其制备和用途

  摘要：

  本发明公开了一类碳糖苷类化合物及其制备和用途，具体涉及如通式(I)所示的一类碳糖苷类化合物及其制备方法，以及含有该类化合物的药物组合物在抑制钠‑葡萄糖协同转运蛋白2(sodium‑dependent glucose transporters 2，SGLT‑2)的生物活性以及在制备治疗和预防糖尿病及其并发症药物中的应用。

  公开号：

  CN112094254B
• 作为产物：
  描述：

  间苯三酚 、 4-甲基苄溴 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.17h， 以65.7%的产率得到2-(4-methylbenzyl)phloroglucinol
  参考文献：
  名称：

  一类碳糖苷类化合物及其制备和用途

  摘要：

  本发明公开了一类碳糖苷类化合物及其制备和用途，具体涉及如通式(I)所示的一类碳糖苷类化合物及其制备方法，以及含有该类化合物的药物组合物在抑制钠‑葡萄糖协同转运蛋白2(sodium‑dependent glucose transporters 2，SGLT‑2)的生物活性以及在制备治疗和预防糖尿病及其并发症药物中的应用。

  公开号：

  CN112094254B

文献信息

• BIS(AMINOPHENOL) DERIVATIVE, PROCESS FOR PRODUCING SAME, POLYAMIDE RESIN, POSITIVE PHOTOSENSITIVE RESIN COMPOSITION, PROTECTIVE FILM, INTERLAYER DIELECTRIC FILM, SEMICONDUCTOR DEVICE, AND DISPLAY ELEMENT
  申请人：Terakawa Koji

  公开号：US20100044888A1

  公开（公告）日：2010-02-25

  A bis(aminophenol) derivative having substituents at positions adjacent to two amino groups is provided. The bis(aminophenol) derivative is used as a raw material of a polyamide resin for a positive-tone photosensitive resin composition. A polyamide resin comprising bis(aminophenol) and a structure derived from a carboxylic acid is also provided, the bis(aminophenol) having substituents at positions adjacent to the two amino groups. A positive-tone photosensitive resin composition comprising a polybenzooxazole precursor resin, exhibiting high sensitivity and a high cyclization rate even when cured at a low temperature is provided. Also provided is a positive-tone photosensitive resin composition comprising a polyamide resin having an imide structure, an imide precursor structure, or an amide acid ester structure. The composition exhibits high sensitivity and produces a cured product having low water absorption even when cured at a low temperature.

  本发明提供了一种在两个氨基团相邻位置上具有取代基的双(氨基酚)衍生物。该双(氨基酚)衍生物用作聚酰胺树脂的原材料，用于制备正向感光树脂组合物。还提供了一种聚酰胺树脂，包括双(氨基酚)和由羧酸衍生的结构，其中双(氨基酚)在两个氨基团相邻位置上具有取代基。提供了一种正向感光树脂组合物，包括聚苯并噁唑前体树脂，即使在低温下固化，也表现出高灵敏度和高环化速率。还提供了一种正向感光树脂组合物，包括具有酰亚胺结构、酰亚胺前体结构或酰胺酸酯结构的聚酰胺树脂。该组合物表现出高灵敏度，即使在低温下固化，也能产生低吸水性的固化产物。
• A multi-enzymatic cascade reaction for the synthesis of bioactive C-oligosaccharides
  作者：Kebo Xie、Qian Zhang、Fei Ye、Jungui Dai

  DOI：10.1016/j.cclet.2023.109028

  日期：2024.6

  successfully achieved by multi-enzymatic cascade reactions. A glycosyltransferase from was employed to introduce the first linked glucose and then a cyclomaltodextrin glucanotransferase from was used to extend the sugar chain. A total of twenty oligosaccharides with 2–6 sugars were synthesized from scale-up reactions and exhibited good water solubility and sodium-dependent glucose transporter 2 (SGLT2) inhibitory

  低聚糖在自然界中很罕见，并且具有多种生物活性。然而，它们的化学合成面临着许多挑战。在这项工作中，通过多酶级联反应成功实现了将连接的糖链酶促引入目标苷元。使用糖基转移酶引入第一个连接的葡萄糖，然后使用环麦芽糖糊精葡聚糖转移酶延伸糖链。通过放大反应合成了总共 20 种含有 2-6 个糖的寡糖，并表现出良好的水溶性和钠依赖性葡萄糖转运蛋白 2 (SGLT2) 抑制活性。此外，使用葡糖淀粉酶控制糖链长度，有效合成麦芽糖苷。这些发现不仅扩大了寡糖的结构多样性，而且为修饰糖苷类药物以提高成药性提供了策略。
• POLYBENZOXAZOLE PRECURSOR, PHOTOSENSITIVE RESIN COMPOSITION USING THE SAME, AND MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE
  申请人：SATO Kenichiro

  公开号：US20080076849A1

  公开（公告）日：2008-03-27

  A polybenzoxazole precursor is represented by the following formula (1): wherein R 1 a to R 4 a, R 1 b to R 4 b, X 1 , Y 1 and m are defined in the specification.
• PHOTOSENSITIVE RESIN COMPOSITION, INSULATING FILM, PROTECTIVE FILM, AND ELECTRONIC EQUIPMENT
  申请人：Toyoda Hideyuki

  公开号：US20100076156A1

  公开（公告）日：2010-03-25

  The photosensitive resin composition of the present invention includes an alkali solubility resin including molecules each composed of a main chain having one end and the other end opposite to the one end, an organic group bonded to the one end thereof, the organic group having at least one unsaturated group, and a substituent group bonded to at least one of the other end of the main chain and a branch thereof, the substituent group having a cyclic chemical structure containing nitrogen atoms, and a photosensitive agent. Further, the insulating film of the present invention is composed of a cured product of the above photosensitive resin composition. Furthermore, the protective film of the present invention is composed of a cured product of the above photosensitive resin composition. Moreover, the Electronic equipment of the present invention is provided with the above protective film and insulating film.
• PROCESS FOR PRODUCING SEMICONDUCTOR DEVICE
  申请人：Banba Toshio

  公开号：US20100183985A1

  公开（公告）日：2010-07-22

  A process for producing a semiconductor device includes a circuit formation step of forming circuit wiring on a semiconductor wafer using a chemically-amplified resist, and a cured film formation step of forming a cured film that protects the circuit wiring after forming the circuit wiring, the cured film being formed of a cured material of a photosensitive resin composition that comprises an alkali-soluble resin having a polybenzoxazole structure or a polybenzoxazole precursor structure, a compound that generates an acid upon exposure to light, and a solvent. The photosensitive resin composition substantially does not contain N-methyl-2-pyrrolidone. The process can suppress a T-top phenomenon or the like that may occur when forming a circuit on a semiconductor wafer using a chemically-amplified resist in the production of semiconductor devices.