4-methyl-2-(2-pyridyl)pentanenitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-methyl-2-(2-pyridyl)pentanenitrile
• 英文别名: 4-Methyl-4-pyridin-2-ylpentanenitrile
• 化学式: C₁₁H₁₄N₂
• 分子量: 174.246
• InChiKey: XPMHWVRHJMAPSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  36.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-乙基吡啶 在 正丁基锂 、 potassium diisopropylamide 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 生成 4-methyl-2-(2-pyridyl)pentanenitrile
  参考文献：
  名称：

  On the metallation of 2-isopropylpyridine

  摘要：

  2-Isopropylpyridine has been successfully metallated and functionalized by using potassium diisopropylamide (KDA). Subsequent functionalization has been achieved with a wide range of electrophiles and good to excellent yields have been obtained. The action of other potassium or sodium bases has also been investigated. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00507-9

文献信息

• Remote C−H Pyridylation of Hydroxamates through Direct Photoexcitation of <i>O</i> ‐Aryl Oxime Pyridinium Intermediates
  作者：Byeongseok Kweon、Changha Kim、Seonyul Kim、Sungwoo Hong

  DOI：10.1002/anie.202112364

  日期：2021.12.13

  designing a new class of photon-absorbing O-aryl oxime pyridinium salts generated in situ from the corresponding pyridines and hydroxamates. This method involves photolytic N−O bond cleavage through the photoexcitation of oxime pyridinium intermediates to generate iminyl radicals, which enable the installation of pyridyl rings at the γ-CN position in complex settings under mild and metal-free conditions.

  异羟肟酸盐的远程 CH 吡啶化是通过设计一类新的光子吸收O-芳基肟吡啶盐，由相应的吡啶和异羟肟酸盐原位生成的。该方法涉及通过肟吡啶鎓中间体的光激发光解 N-O 键以产生亚胺基自由基，从而能够在温和和无金属条件下的复杂环境中在 γ-CN 位置安装吡啶环。
• On the metallation of 2-isopropylpyridine
  作者：Eric Pasquinet、Patrick Rocca、Francis Marsais、Alain Godard、Guy Quéguiner

  DOI：10.1016/s0040-4020(98)00507-9

  日期：1998.7

  2-Isopropylpyridine has been successfully metallated and functionalized by using potassium diisopropylamide (KDA). Subsequent functionalization has been achieved with a wide range of electrophiles and good to excellent yields have been obtained. The action of other potassium or sodium bases has also been investigated. (C) 1998 Elsevier Science Ltd. All rights reserved.

表征谱图