quinidine N-oxide

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 英文名称: quinidine N-oxide
• 英文别名: (S)-[(2R,4S,5R)-5-ethenyl-1-oxido-1-azoniabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
• 化学式: C₂₀H₂₄N₂O₃
• 分子量: 340.422
• InChiKey: WVDIZKMXQMCCAA-IKJOXUIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  4

ADMET

代谢

盐酸奎尼丁-N-氧化物是奎尼丁的人类已知代谢物。

Quinidine-N-oxide is a known human metabolite of quinidine.

来源:NORMAN Suspect List Exchange

反应信息

• 作为反应物：
  描述：

  quinidine N-oxide 、 potassium permanganate 以50%的产率得到
  参考文献：
  名称：

  DIAZ-ARAUZO, HERNANDO;COOK, JAMES M.;CHRISTIE, DOUGLAS, J. NATUR. PROD., 53,(1990) N, C. 112-124

  摘要：

  DOI：
• 作为产物：
  描述：

  奎尼丁 生成 quinidine N-oxide
  参考文献：
  名称：

  Ludwig, Eva; Schmid, Jochen; Beschke, Klaus, Journal of Pharmacology and Experimental Therapeutics, 1999, vol. 290, # 1, p. 1 - 8

  摘要：

  DOI：

文献信息

• Transformation of Cinchona Alkaloids into 1-N-Oxide Derivatives by Endophytic Xylaria sp. Isolated from Cinchona pubescens.
  作者：Hirotaka Shibuya、Chinami Kitamura、Shoji Maehara、Marie Nagahata、Hendig Winarno、Partomuan Simanjuntak、Hye-Sook Kim、Yusuke Wataya、Kazuyoshi Ohashi

  DOI：10.1248/cpb.51.71

  日期：——

  The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.

  研究了从金鸡纳树分离的内生真菌对四种金鸡纳生物碱（奎宁，奎尼丁，金鸡尼定和金鸡尼碱）的微生物转化。内生丝状真菌Xylaria sp。发现将金鸡纳生物碱转化为其1-N-氧化物衍生物。
• [EN] PROCESS FOR PREPARING DIASTEREOMERICALLY ENRICHED PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE PHOSPHORAMIDATES ENRICHIS EN DIASTÉRÉO-ISOMÈRES DE COMPOSÉS DE NUCLÉOSIDES, DESTINÉS AU TRAITEMENT D'INFECTIONS VIRALES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014008236A1

  公开（公告）日：2014-01-09

  The present invention is directed to a process for preparing diastereomerically enriched nucleoside phosphoramidates having the formula I:

  本发明涉及一种制备具有化学式I的对映异构体富集的核苷磷酰胺酯的方法。
• PROCESS FOR PREPARING DIASTEREOMERICALLY ENRICHED PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150183818A1

  公开（公告）日：2015-07-02

  The present invention is directed to a process for preparing diastereomerically enriched nucleoside phosphoramidates having the formula I:

  本发明涉及一种制备式I的对映体富集核苷酸磷酰胺酯的方法：
• [EN] STEREOSELECTIVE MANUFACTURE OF SELECTED PURINE PHOSPHORAMIDATES<br/>[FR] PRODUCTION STÉRÉOSÉLECTIVE DE PHOSPHORAMIDATES DE PURINE SÉLECTIONNÉS
  申请人：ATEA PHARMACEUTICALS INC

  公开号：WO2022040473A1

  公开（公告）日：2022-02-24

  The present invention provides stereoselective processes of manufacture for the phosphoramidate nucleotide Compound 1 or a pharmaceutically acceptable salt thereof.

  本发明提供了制造磷酰胺酰核苷化合物1或其药学上可接受的盐的立体选择性过程。
• Quinidine immunoassay and reagents
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0745602A1

  公开（公告）日：1996-12-04

  The invention provides: novel quinidine derivatives of formula wherein L is a a C1-C10 hydrocarbon linking group which may be straight or branched chain, saturated or unsaturated, and may include from 0 to 3 heteroatoms; and F is a functional group selected from the group consisting of amino, carboxyl, sulfhydryl, imino, and maleimide, haptens, immunogens, antibodies and tracers produced from those novel derivatives, and an improved quinidine fluorescence polarization immunoassay utilizing those antibodies and tracers.

  本发明提供了 式中 L 为 C1-C10 烃连接基团，可以是直链或支链、饱和或不饱和，并可包括 0 至 3 个杂原子；F 为官能团，选自由氨基、羧基、巯基、亚氨基和马来酰亚胺组成的组；由这些新型衍生物制备的触媒、免疫原、抗体和示踪剂；以及利用这些抗体和示踪剂的改进型奎尼丁荧光偏振免疫分析法。