5-fluoro-2,3-dihydro-3-(tetrahydrofuran-2-yl)-2,6-dioxopyrimidin-1(6H)-ylmethyl butyrate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-fluoro-2,3-dihydro-3-(tetrahydrofuran-2-yl)-2,6-dioxopyrimidin-1(6H)-ylmethyl butyrate
• 英文别名: [5-Fluoro-2,6-dioxo-3-(oxolan-2-yl)pyrimidin-1-yl]methyl butanoate
• 化学式: C₁₃H₁₇FN₂O₅
• 分子量: 300.287
• InChiKey: VQTJKRBLTHCKJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  76.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丁酸氯甲酯 、 替加氟 在 potassium carbonate 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 20.0h， 以83%的产率得到5-fluoro-2,3-dihydro-3-(tetrahydrofuran-2-yl)-2,6-dioxopyrimidin-1(6H)-ylmethyl butyrate
  参考文献：
  名称：

  [EN] DERIVATIVES OF CHEMOTHERAPEUTIC AGENTS WITH A FORMALDEHYDE RELEASING MOEITY
  [FR] DERIVES D'AGENTS CHIMIOTHERAPEUTIQUES ET UTILISATIONS

  摘要：

  公开号：

  WO2005120577A3

文献信息

• Derivatives Of Chemotherapeutic Agents With A Formaldehyde Releasing Moiety
  申请人：Nudelman Abraham

  公开号：US20070293517A1

  公开（公告）日：2007-12-20

  Novel conjugates of chemotherapeutic agents, which are designed so as to release formaldehyde or analogs thereof upon cleavage, processes of preparing same, pharmaceutical compositions containing same and methods utilizing same for treating medical conditions such as cancer, immune-mediated diseases, viral infections and diseases, bacterial infections and diseases, fungal infections and diseases, protozal infections and diseases and more, and particularly for treating such conditions which are characterized by drug resistance are provided.
• [EN] NOVEL DERIVATIVES OF CHEMOTHERAPEUTIC AGENTS AND USES THEREOF<br/>[FR] DERIVES D'AGENTS CHIMIOTHERAPEUTIQUES ET UTILISATIONS
  申请人：UNIV RAMOT

  公开号：WO2005120577A2

  公开（公告）日：2005-12-22

  Novel conjugates of chemotherapeutic agents, which are designed so as to release formaldehyde or analogs thereof upon cleavage, processes of preparing same, pharmaceutical compositions containing same and methods utilizing same for treating medical conditions such as cancer, immune-mediated diseases, viral infections and diseases, bacterial infections and diseases, fungal infections and diseases, protozal infections and diseases and more, and particularly for treating such conditions which are characterized by drug resistance are provided.
• [EN] DERIVATIVES OF CHEMOTHERAPEUTIC AGENTS WITH A FORMALDEHYDE RELEASING MOEITY<br/>[FR] DERIVES D'AGENTS CHIMIOTHERAPEUTIQUES ET UTILISATIONS
  申请人：UNIV RAMOT

  公开号：WO2005120577A3

  公开（公告）日：2006-08-31