3-(anthracen-9-yl)-1-(furan-2-yl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 3-(anthracen-9-yl)-1-(furan-2-yl)prop-2-en-1-one
• 英文别名: 3-(9-Anthryl)-1-(2-furyl)prop-2-en-1-one；(E)-3-anthracen-9-yl-1-(furan-2-yl)prop-2-en-1-one
• 化学式: C₂₁H₁₄O₂
• 分子量: 298.341
• InChiKey: QURKMPLWUBYYQJ-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(anthracen-9-yl)-1-(furan-2-yl)prop-2-en-1-one 在 一水合肼 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 16.0h， 生成 5-(anthracen-9-yl)-3-(furan-2-yl)-1-(1-(2-(4-nitrophenyl)hydrazono)ethyl)-4,5-dihydro-1H-pyrazole
  参考文献：
  名称：

  Synthesis and biological activity of some new pyrazoline and pyrimidine derivatives

  摘要：

  New series of pyrazoline 3-aryl-4,5-dihydro-1H-pyrazole-1-carbaldehydes (4-6), (aryl-4,5-dihydro-1H-pyrazol-1-yl) ethanones (9-11) and 3-aryl-4,5-dihydro-1H-pyrazoles (24 and 25) were synthesized by reacting chalcones (1-3) with hydrazine hydrate in either formic acid, acetic acid or ethanol, respectively. Also, new 6-arylpyrimidin-2-amine derivatives (32-34) were synthesized from the same chalcones. The structures of the newly synthesized compounds were established on the basis of IR, H-1 NMR, C-13 NMR, mass spectral data and elemental analyses. The compounds were evaluated for their antibacterial and antifungal activities. Three heterocycles showed relevant activity against C. albicans and some compounds also showed activity against E. coli.

  DOI：

  10.1590/s0103-50532011000700014
• 作为产物：
  描述：

  2-乙酰基呋喃 、 9-蒽甲醛 在 potassium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 以87%的产率得到3-(anthracen-9-yl)-1-(furan-2-yl)prop-2-en-1-one
  参考文献：
  名称：

  Synthesis and biological activity of some new pyrazoline and pyrimidine derivatives

  摘要：

  New series of pyrazoline 3-aryl-4,5-dihydro-1H-pyrazole-1-carbaldehydes (4-6), (aryl-4,5-dihydro-1H-pyrazol-1-yl) ethanones (9-11) and 3-aryl-4,5-dihydro-1H-pyrazoles (24 and 25) were synthesized by reacting chalcones (1-3) with hydrazine hydrate in either formic acid, acetic acid or ethanol, respectively. Also, new 6-arylpyrimidin-2-amine derivatives (32-34) were synthesized from the same chalcones. The structures of the newly synthesized compounds were established on the basis of IR, H-1 NMR, C-13 NMR, mass spectral data and elemental analyses. The compounds were evaluated for their antibacterial and antifungal activities. Three heterocycles showed relevant activity against C. albicans and some compounds also showed activity against E. coli.

  DOI：

  10.1590/s0103-50532011000700014

文献信息

• Synthesis of 1-substituted 3,5-diaryl-2-pyrazolines by the reaction of α,β-unsaturated ketones with hydrazines
  作者：Albert Lévai、József Jekö

  DOI：10.1002/jhet.5570430117

  日期：2006.1

  1-Acetyl-, 1-propionyl- and 1-phenyl-3,5-diaryl-2-pyrazolines have been synthesized by the reaction of the appropriate α,β-unsaturated ketones with hydrazine or phenylhydrazine in hot acetic acid or propionic acid. Structures of all new 2-pyrazolines 16-40 have been elucidated by microanalyses, 1H and 13C nmr spectroscopies.

  通过适当的α，β-不饱和酮与肼或苯肼在热乙酸或丙酸中的反应，已经合成了1-乙酰基，1-丙酰基-和1-苯基-3，5-二芳基-2-吡唑啉。所有新的2-吡唑啉16-40的结构已通过微量分析，1 H和13 C nmr光谱学得以阐明。
• Synthesis and biological activity of some new pyrazoline and pyrimidine derivatives
  作者：Seham Y Hassan

  DOI：10.1590/s0103-50532011000700014

  日期：——

  New series of pyrazoline 3-aryl-4,5-dihydro-1H-pyrazole-1-carbaldehydes (4-6), (aryl-4,5-dihydro-1H-pyrazol-1-yl) ethanones (9-11) and 3-aryl-4,5-dihydro-1H-pyrazoles (24 and 25) were synthesized by reacting chalcones (1-3) with hydrazine hydrate in either formic acid, acetic acid or ethanol, respectively. Also, new 6-arylpyrimidin-2-amine derivatives (32-34) were synthesized from the same chalcones. The structures of the newly synthesized compounds were established on the basis of IR, H-1 NMR, C-13 NMR, mass spectral data and elemental analyses. The compounds were evaluated for their antibacterial and antifungal activities. Three heterocycles showed relevant activity against C. albicans and some compounds also showed activity against E. coli.