decyl 2-[decyl(dimethyl)ammonio]ethylphosphate

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: decyl 2-[decyl(dimethyl)ammonio]ethylphosphate
• 英文别名: Decyl 2-(decyldimethylammonio)ethyl phosphate；decyl 2-[decyl(dimethyl)azaniumyl]ethyl phosphate
• 化学式: C₂₄H₅₂NO₄P
• 分子量: 449.655
• InChiKey: KRXVLBSWJJJWDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  30
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  癸醇 、 alkaline earth salt of/the/ methylsulfuric acid 在 三乙胺 作用下， 以 四氢呋喃 、 乙醚 、 乙腈 为溶剂， 反应 52.0h， 生成 decyl 2-[decyl(dimethyl)ammonio]ethylphosphate
  参考文献：
  名称：

  Zwitterionic Geminis. Coacervate Formation from a Single Organic Compound

  摘要：

  [GRAPHICS]Easily "tunable" zwitterionic gemini surfactants were prepared with a wide variety of chain combinations. These geminis self-assemble into micelles, vesicles, and tubules at low concentrations in water, Two particularly remarkable geminis form a coacervate whose "sponge-like" structure is visible by cryo-high-resolution scanning electron microscopy.

  DOI：

  10.1021/ol990205g

文献信息

• Synthesis and biological activity of dialkylphosphocholines
  作者：Miloš Lukáč、Martin Mrva、Eva Fischer-Fodor、Ivan Lacko、Marián Bukovský、Natalia Miklášová、František Ondriska、Ferdinand Devínsky

  DOI：10.1016/j.bmcl.2009.09.079

  日期：2009.11

  A series of dialkylphosphocholines were prepared and evaluated for their biological activity. The antiprotozoal activity was determined against Acanthamoeba lugdunensis. Compound 15 exhibited excellent trophocidal activity. None of the tested dialkylphosphocholines exhibited better fungicidal activity against Candida albicans than miltefosine. The antineoplastic activity was determined against HeLa. The most cytotoxic was compound 10, which was more active against tumor cells as against normal cells. (C) 2009 Elsevier Ltd. All rights reserved.
• Zwitterionic Geminis. Coacervate Formation from a Single Organic Compound
  作者：Andrey V. Peresypkin、Fredric M. Menger

  DOI：10.1021/ol990205g

  日期：1999.11.1

  [GRAPHICS]Easily "tunable" zwitterionic gemini surfactants were prepared with a wide variety of chain combinations. These geminis self-assemble into micelles, vesicles, and tubules at low concentrations in water, Two particularly remarkable geminis form a coacervate whose "sponge-like" structure is visible by cryo-high-resolution scanning electron microscopy.
• A Combinatorially-Derived Structural Phase Diagram for 42 Zwitterionic Geminis
  作者：Fredric M. Menger、Andrey V. Peresypkin

  DOI：10.1021/ja003779l

  日期：2001.6.1