(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3,4-dimethoxybenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3,4-dimethoxybenzoate
• 英文别名: [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 3,4-dimethoxybenzoate
• 化学式: C₁₉H₂₈O₄
• 分子量: 320.429
• InChiKey: VLHOGGRSYLACGN-UKPHBRMFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  L-薄荷醇 、 3,4-二甲氧基苯甲酰氯 在 吡啶 作用下， 以 乙醚 为溶剂， 以95%的产率得到(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3,4-dimethoxybenzoate
  参考文献：
  名称：

  Preparation of Chiral Amine Carbonyl Chromium(0) Complexes with [(Norbornadiene)Cr(CO)4] as the Complexation Reagent

  摘要：

  A number of chiral amines were prepared and used as ligands in carbonylchromium(0) complexes. Included are monoamines, chelating diamines and methionine methyl ester, For their complexation (norbornadiene)tetracarbonylchromium(0) was found to allow complexation in high, sometimes quantitative yields in boiling THF (65 degrees C). The amine complexes prepared could be used as complexation reagents for arenes in up to 81% yield in the presence of boron trifluoride-diethyl ether adduct if THF was used as the solvent. Significant chirality transfer from the chiral complexation reagents to the chiral arene complexes was, however, not observed.

  DOI：

  10.1002/1099-0690(200006)2000:12<2273::aid-ejoc2273>3.0.co;2-m

文献信息

• Preparation of Chiral Amine Carbonyl Chromium(0) Complexes with [(Norbornadiene)Cr(CO)4] as the Complexation Reagent
  作者：Markus Strotmann、Holger Butenschön

  DOI：10.1002/1099-0690(200006)2000:12<2273::aid-ejoc2273>3.0.co;2-m

  日期：2000.6

  A number of chiral amines were prepared and used as ligands in carbonylchromium(0) complexes. Included are monoamines, chelating diamines and methionine methyl ester, For their complexation (norbornadiene)tetracarbonylchromium(0) was found to allow complexation in high, sometimes quantitative yields in boiling THF (65 degrees C). The amine complexes prepared could be used as complexation reagents for arenes in up to 81% yield in the presence of boron trifluoride-diethyl ether adduct if THF was used as the solvent. Significant chirality transfer from the chiral complexation reagents to the chiral arene complexes was, however, not observed.