isatin-Girard P

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: isatin-Girard P
• 英文别名: 1-{2-oxo-2-[(2Z)(2-oxo-1,2-dihydro-3H-indole-3-ylidene)hydrazine]ethyl}pyridinium chloride；Girard’s P hydrazone；N-[(2-hydroxy-1H-indol-3-yl)imino]-2-pyridin-1-ium-1-ylacetamide;chloride
• 化学式: C₁₅H₁₃N₄O₂*Cl
• 分子量: 316.747
• InChiKey: LQNUTKNUJKBWIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.52
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  81.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  aluminum (III) chloride 、 isatin-Girard P 以 乙醇 、 水 为溶剂， 以50%的产率得到[Al(1-{2-oxo-2-[(2Z)(2-oxo-1,2-dihydro-3H-indole-3-ylidene)hydrazine]ethyl}pyridinium)Cl3]Cl
  参考文献：
  名称：

  Synthesis, characterization and modeling structures of isatin-3-Girard T (IGT) and P (IGP) hydrazone complexes

  摘要：

  The reactions of isatin Girard's T hydrazone, N,N,N-trimethyl-2-oxo-2[(2z)-2-(2-oxo-1,2-dihydro-3H-indole-3-ylidene)hydrazino]ethan ammonium chloride (IGT) and isatin Girard's P hydrazone, 1-{2-oxo-2-[(2z)(2-oxo-1,2-dihydro-3H-indole-3-ylidene)hydrazine]ethyl} pyridinium chloride (IGP), with Fe(3+), Al(3+), Sb(3+) and Sn(2+) salts afford different types of complexes. The isolated solid complexes were characterized by elemental analyses, molar conductance, spectral (IR, UV-Vis, (1)H NMR, mass), magnetic moment and thermal measurements. The results suggest that all the complexes are conducting in polar solvents (EtOH, H2O and DMF). The IR spectral data suggest that the ligands coordinate in a tridentate manner via the two carbonyl of both isatin and Girard's and the azomethine (C=N) groups. The amounts of solvents inside and outside the coordination sphere were determined using thermal data (TGA) and weight loss method. The octahedral geometry of the complexes is confirmed using DFT method from DMOL(3) calculations. The ligands and their metal complexes were tested against different strains of bacteria and fungi.

  DOI：

  10.1016/j.saa.2014.01.082
• 作为产物：
  描述：

  N-氯-N-吡啶基乙酰肼 、 靛红 以 乙醇 、 溶剂黄146 为溶剂， 反应 2.0h， 生成 isatin-Girard P
  参考文献：
  名称：

  Khattab, M. A.; Ghoneim, M. M., Journal of the Indian Chemical Society, 1983, vol. 60, p. 643 - 646

  摘要：

  DOI：

文献信息

• Synthesis, characterization and modeling structures of isatin-3-Girard T (IGT) and P (IGP) hydrazone complexes
  作者：Sabah Salah、Zeinab H. Abd El-Wahab、Rabei S. Farag、Mohsen M. Mostafa

  DOI：10.1016/j.saa.2014.01.082

  日期：2014.4

  The reactions of isatin Girard's T hydrazone, N,N,N-trimethyl-2-oxo-2[(2z)-2-(2-oxo-1,2-dihydro-3H-indole-3-ylidene)hydrazino]ethan ammonium chloride (IGT) and isatin Girard's P hydrazone, 1-2-oxo-2-[(2z)(2-oxo-1,2-dihydro-3H-indole-3-ylidene)hydrazine]ethyl} pyridinium chloride (IGP), with Fe(3+), Al(3+), Sb(3+) and Sn(2+) salts afford different types of complexes. The isolated solid complexes were characterized by elemental analyses, molar conductance, spectral (IR, UV-Vis, (1)H NMR, mass), magnetic moment and thermal measurements. The results suggest that all the complexes are conducting in polar solvents (EtOH, H2O and DMF). The IR spectral data suggest that the ligands coordinate in a tridentate manner via the two carbonyl of both isatin and Girard's and the azomethine (C=N) groups. The amounts of solvents inside and outside the coordination sphere were determined using thermal data (TGA) and weight loss method. The octahedral geometry of the complexes is confirmed using DFT method from DMOL(3) calculations. The ligands and their metal complexes were tested against different strains of bacteria and fungi.
• Khattab, M. A.; Ghoneim, M. M., Journal of the Indian Chemical Society, 1983, vol. 60, p. 643 - 646
  作者：Khattab, M. A.、Ghoneim, M. M.

  DOI：——

  日期：——