2-methyl-5-(m-tolyl)-1,3,4-thiadiazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-5-(m-tolyl)-1,3,4-thiadiazole
• 英文别名: 2-Methyl-5-(3-methylphenyl)-1,3,4-thiadiazole
• 化学式: C₁₀H₁₀N₂S
• 分子量: 190.269
• InChiKey: VKICFOWNNQOIOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-methyl(thiobenzoyl)lhydrazine 、 N,N-二甲基乙酰胺 在 potassium hydrogensulfate 作用下， 反应 5.0h， 以74%的产率得到2-methyl-5-(m-tolyl)-1,3,4-thiadiazole
  参考文献：
  名称：

  A KHSO4 promoted tandem synthesis of 1,3,4-thiadiazoles from thiohydrazides and DMF derivatives

  摘要：

  An efficient, simple and environmentally benign method for the construction of 1,3,4-thiadiazole skeletons via the tandem coupling and cyclization of thiohydrazides with DMF derivatives in the presence of KHSO4 has been reported. This method reveals good reactivity and functional group tolerance, and a broad series of 1,3,4-thiadiazoles were obtained in moderate to good yields. (C) 2020 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2020.152195

文献信息

• [EN] TRICYCLIC PYRAZOL AMINE DERIVATIVES<br/>[FR] DÉRIVÉS TRICYCLIQUES DE PYRAZOLAMINE
  申请人：MERCK SERONO SA

  公开号：WO2011058149A1

  公开（公告）日：2011-05-19

  This invention relates to compounds of Formula (I*) as Pi3k inhibitors for treating autoimmune diseases, inflammatory disorders, multiple sclerosis and other diseases like cancers.

  这项发明涉及到 Formula (I*) 的化合物作为 Pi3k 抑制剂，用于治疗自身免疫疾病、炎症性疾病、多发性硬化等疾病，以及癌症等其他疾病。
• PYRIMIDODIAZEPINONE DERIVATIVE
  申请人：Otsubo Nobumasa

  公开号：US20100190775A1

  公开（公告）日：2010-07-29

  The invention provides a pyrimidodiazepinone derivative represented by the general formula (I) [wherein n represents 1 or 2, Z represents a hydrogen atom or the like, R 1 and R 2 may be the same or different, and each represents a hydrogen atom or the like, A represents a bond, (CH 2 ) m (wherein m represents an integer of 1 to 4), optionally substituted phenylene, optionally substituted pyridinediyl, or C═O, R 3 represents a hydrogen atom, optionally substituted lower alkyl, or the like, and R 4 represents a hydrogen atom or the like], or a pharmaceutically acceptable salt thereof or the like.

  该发明提供了一种由通式(I)表示的嘧啶二氮杂环酮衍生物[其中n代表1或2，Z代表氢原子或类似物，R1和R2可以相同或不同，每个代表氢原子或类似物，A代表键合，(CH2)m(其中m代表1到4的整数)、可选取代的苯基、可选取代的吡啶二基、或C═O，R3代表氢原子、可选取代的较低烷基或类似物，R4代表氢原子或类似物]，或其药学上可接受的盐或类似物。
• TRICYCLIC PYRAZOL AMINE DERIVATIVES
  申请人：Merck Serono S.A.

  公开号：EP2499146B1

  公开（公告）日：2016-09-21
• Ink for inkjet printing ink set for inkjet printing inkjet recording material and producing method for inkjet recording material and inkjet recording method
  申请人：Taguchi Toshiki

  公开号：US20070052783A1

  公开（公告）日：2007-03-08

  At least one of an ink for inkjet printing and an inkjet recording material contains a compound represented by formula (A): wherein R 1 , R 2 and R 3 each represents an alkyl group, an aryl group or a heterocyclic group, and at least two of R 1 , R 2 and R 3 are mutually connected to form a cyclic structure; L represents a divalent connecting group; and at least one of R 1 , R 2 , R 3 and L is a group having 8 or more carbon atoms.
• Ink composition, ink set and recording method
  申请人：Ogawa Manabu

  公开号：US20070070159A1

  公开（公告）日：2007-03-29

  An ink composition includes: a coloring material having an azo group bound to a heterocyclic group; an aqueous medium; and at least one of an acetylene diol and an ethylene oxide adduct of the acetylene diol, wherein an average value of an addition molar number of the at least one of the acetylene diol and the ethylene oxide adduct of the acetylene diol is 0 or more and less than 4.