3-methyl-4-[N,N-bis(2-hydroxyethyl)amino]nitrobenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methyl-4-[N,N-bis(2-hydroxyethyl)amino]nitrobenzene
• 英文别名: 2-[N-(2-hydroxyethyl)-2-methyl-4-nitroanilino]ethanol
• 化学式: C₁₁H₁₆N₂O₄
• mdl: MFCD13293216
• 分子量: 240.259
• InChiKey: COFYJRVXGBSATP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  89.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-methyl-4-[N,N-bis(2-hydroxyethyl)amino]nitrobenzene 在 氯化亚砜 作用下， 以 苯 为溶剂， 以92%的产率得到3-Methyl-4-[N,N-bis(2-chloroethyl)amino]nitrobenzene
  参考文献：
  名称：

  Benzimidazole derivatives

  摘要：

  以下是化学式（I）表示的化合物及其药理学上可接受的盐，它们是一种新型化合物，可作为抗癌剂、抗病毒剂或抗微生物剂使用。

  公开号：

  US05852011A1
• 作为产物：
  描述：

  2-氟-5-硝基甲苯 、 二乙醇胺 以 二甲基亚砜 为溶剂， 以84%的产率得到3-methyl-4-[N,N-bis(2-hydroxyethyl)amino]nitrobenzene
  参考文献：
  名称：

  Benzimidazole derivatives

  摘要：

  以下是化学式（I）表示的化合物及其药理学上可接受的盐，它们是一种新型化合物，可作为抗癌剂、抗病毒剂或抗微生物剂使用。

  公开号：

  US05852011A1

文献信息

• BENZIMIDAZOLE DERIVATIVE
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0711768A1

  公开（公告）日：1996-05-15

  Disclosed are compounds represented by the following chemical formula (I) and pharmacologically acceptable salts thereof which are novel compounds useful as anticancer agents, antiviral agents or antimicrobial agents.

  所公开的是由以下化学式（I）代表的化合物及其药理学上可接受的盐类，它们是可用作抗癌剂、抗病毒剂或抗菌剂的新型化合物。
• INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION
  申请人：Abbott Laboratories

  公开号：EP1250332A1

  公开（公告）日：2002-10-23
• Ophthalmological Composition And Use Thereof
  申请人：Ritter Helmut

  公开号：US20100324165A1

  公开（公告）日：2010-12-23

  The subject matter of the present invention is an ophthalmologic composition having an UV absorber and a violet absorber, wherein a high transmission is achieved in the blue light spectrum, and an eye implant, in particular an intraocular lens, which is produced with this ophthalmologic composition.
• Copolymer and Ophthalmological Composition
  申请人：Ritter Helmut

  公开号：US20110028667A1

  公开（公告）日：2011-02-03

  The invention relates to a copolymer, which includes 20 to 95 percent by weight, based on the total weight of the copolymer, of structural units derived from at least one hydrophilic monomer, and 5 to 80 percent by weight, based on the total weight of the copolymer, of structural units derived from at least one monomer according to the general formula I wherein R 1 , R 2 and R 3 each independently of each other denote hydrogen or alkyl-, Y: denotes O or NR 4 with R 4 selected from hydrogen or alkyl-, X: denotes O, S, SO or SO 2 , S denotes a structural unit selected from CHR 5 or (CHR 5 CHR 5 O) i CH 2 , wherein all of the R 5 each independently of each other denote hydrogen or alkyl-, n and i independently of each other denote an integer between 1 and 10 and m denotes an integer between 2 and 6, and wherein the copolymer has a water content from 1 to 59 percent by weight based on the total weight of the copolymer. Furthermore, the invention relates to an ophthalmologic composition.
• US5852011A
  申请人：——

  公开号：US5852011A

  公开（公告）日：1998-12-22