2-methyl-3-(p-isopropylphenyl)-2-(4''-toluenesulfonylamino)propionaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-3-(p-isopropylphenyl)-2-(4''-toluenesulfonylamino)propionaldehyde
• 英文别名: 4-methyl-N-[2-methyl-1-oxo-3-(4-propan-2-ylphenyl)propan-2-yl]benzenesulfonamide
• 化学式: C₂₀H₂₅NO₃S
• 分子量: 359.489
• InChiKey: UCRBXTOSXPMWBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  71.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  兔耳草醛 、 chloroamine-T 在 L-脯氨酸 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以83%的产率得到2-methyl-3-(p-isopropylphenyl)-2-(4''-toluenesulfonylamino)propionaldehyde
  参考文献：
  名称：

  Sulfamidation of 2-Arylaldehydes and Ketones with Chloramine-T

  摘要：

  A series of aliphatic and aromatic carbonyl compounds has been transformed into the corresponding sulfamidated products by means of amine-catalyzed nitrene transfer of chloramine-T. Depending on the residues R, either alpha-sulfamidation in the case of aromatic aldehydes and acetone derivatives or direct sulfamidation at the carbonyl functionality of aliphatic aldehydes has been observed. Applying microwave conditions, good to excellent yields under significantly reduced reaction times could be obtained, thus providing a facile access to alpha, alpha-disubstituted amino acids.

  DOI：

  10.1021/ol061410g

文献信息

• Sulfamidation of 2-Arylaldehydes and Ketones with Chloramine-T
  作者：Thomas Baumann、Michael Bächle、Stefan Bräse

  DOI：10.1021/ol061410g

  日期：2006.8.1

  A series of aliphatic and aromatic carbonyl compounds has been transformed into the corresponding sulfamidated products by means of amine-catalyzed nitrene transfer of chloramine-T. Depending on the residues R, either alpha-sulfamidation in the case of aromatic aldehydes and acetone derivatives or direct sulfamidation at the carbonyl functionality of aliphatic aldehydes has been observed. Applying microwave conditions, good to excellent yields under significantly reduced reaction times could be obtained, thus providing a facile access to alpha, alpha-disubstituted amino acids.