acetylleucine aldehyde

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acetylleucine aldehyde
• 英文别名: N-acetylleucinone；2-Acetamido-4-methyl-valeraldehyd；N-[(2S)-4-methyl-1-oxopentan-2-yl]acetamide
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: OCKLDMXNAWIJHV-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-乙酰-L-亮氨酸 生成 acetylleucine aldehyde
  参考文献：
  名称：

  Seki,H. et al., Chemical and pharmaceutical bulletin, 1972, vol. 20, p. 361 - 367

  摘要：

  DOI：

文献信息

• Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity
  申请人：Nastech Pharmaceutical Company Inc.

  公开号：US20040157777A1

  公开（公告）日：2004-08-12

  Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY(PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.

  描述了包含至少一种Y2受体结合肽（如肽YY（PYY）、神经肽Y（NPY）或胰岛素肽（PP））和一种或多种黏膜传递增强剂的药物组合物和方法，以增强肽YY在鼻黏膜中的传递，用于治疗哺乳动物主体中的多种疾病和病况，包括肥胖。
• Protease inhibitors
  申请人：SmithKline Beecham Corporation

  公开号：US20020173469A1

  公开（公告）日：2002-11-21

  The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

  本发明提供了一种抑制蛋白酶的化合物，包括卡他普星K，以及这些化合物的药物组合物和治疗骨量过度流失或软骨或基质降解疾病的方法，包括骨质疏松症；牙龈疾病，包括牙龈炎和牙周炎；关节炎，更具体地说是骨关节炎和类风湿性关节炎；帕吉特病；恶性高钙血症；以及代谢性骨病，通过向需要治疗的患者投与本发明的化合物来抑制骨量过度流失或过度软骨或基质降解。
• Oral drug delivery compositions and methods
  申请人：Emisphere Technologies, Inc.

  公开号：US20030012817A1

  公开（公告）日：2003-01-16

  The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form drug containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.

  本发明涉及一种口服药物输送系统，具体涉及用于作为敏感剂的生物活性肽的传递系统的修饰氨基酸和修饰氨基酸衍生物。修饰氨基酸和衍生物可以与活性生物制剂形成非共价混合物，并且在另一实施例中可以释放携带活性剂。修饰氨基酸还可以形成含药微球。这些混合物适用于将生物活性剂口服给动物。还公开了制备这种氨基酸的方法。
• COMPOSITIONS AND METHODS FOR ENHANCED MUCOSAL DELIVERY OF PYY PEPTIDE
  申请人：Quay C. Steven

  公开号：US20070129299A1

  公开（公告）日：2007-06-07

  Pharmaceutical compositions are described comprising PYY(3-36) (SEQ ID NO: 2), a solubilizing agent, a lipid, a polyol.

  本文描述了一种药物组合物，其中包含PYY(3-36) (序列ID号：2)，一种溶解剂，一种脂质和一种多元醇。
• A DEVICE FOR ENHANCED EPITHELIAL PERMEATION OF Y2 RECEPTOR-BINDING PEPTIDES
  申请人：Quay C. Steven

  公开号：US20070161563A1

  公开（公告）日：2007-07-12

  A pharmaceutical device comprising a composition comprising an aqueous solution of PYY(3-36), a cyclodextrin, and a compound selected from phosphatidylcholine or diglyceride, wherein the cyclodextrin and the compound selected from phosphatidylcholine or diglyceride are present in an amount sufficient to enhance epithelial permeation, and wherein the composition is present in a container; and an actuator fluidly connected to the container, wherein the actuator has a tip which defines a passage through which the solution is ejected to produce a spray of the solution.

  一种药物器具，包括一种组合物，该组合物包括PYY（3-36）的水溶液、环糊精和从磷脂酰胆碱或二甘酸选择的化合物，其中环糊精和从磷脂酰胆碱或二甘酸选择的化合物的含量足以增强上皮渗透，且该组合物存在于容器中；以及与容器流体连接的作动器，其中作动器具有一个尖端，其定义了一个通道，通过该通道喷射出解液以产生解液喷雾。