2-(4'-methyl-[1,1'-biphenyl]-2-yl)acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4'-methyl-[1,1'-biphenyl]-2-yl)acetic acid
• 英文别名: (4'-methyl-biphenyl-2-yl)acetic acid；2-(para-tolyl)phenylacetic acid；2-[2-(4-methylphenyl)phenyl]acetic Acid
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: LQNNDNWIGOUTSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4'-methyl-[1,1'-biphenyl]-2-yl)acetic acid 在 dipotassium peroxodisulfate 作用下， 以 水 为溶剂， 以52 %的产率得到2-甲基-9H-芴-9-酮
  参考文献：
  名称：

  pH-Controlled Intramolecular Decarboxylative Cyclization of Biarylacetic Acids: Implication on Umpolung Reactivity of Aroyl Radicals

  摘要：

  DOI：

  10.1021/acs.joc.2c00295
• 作为产物：
  描述：

  扁桃酸 生成 2-(4'-methyl-[1,1'-biphenyl]-2-yl)acetic acid
  参考文献：
  名称：

  N-substituted heterocyclic derivatives useful in the treatment of

  摘要：

  本发明涉及公式为N-取代杂环衍生物的化合物，其制备方法以及含有它们的药物组合物。根据本发明的化合物是非肽类化合物，可以对抗血管紧张素II的作用。因此，根据本发明的化合物在治疗高血压和心力衰竭等心血管疾病方面具有用途。

  公开号：

  US05274104A1

文献信息

• 2-ALKOXYMETHYL-3-ISOALKENYL-1-METHYLCYCLOPENTENES, USE THEREOF, IN PARTICULAR AS FRAGRANCE SUBSTANCES, CORRESPONDING ARTICLES AND PRODUCTION METHODS
  申请人：Panten Johannes

  公开号：US20090092725A1

  公开（公告）日：2009-04-09

  Compounds of formula (A) are described wherein, independently of one another, the following applies to groups R and R 1 : R is methyl or ethyl, and R 1 is hydrogen or methyl, wherein the meandering line shows that for R 1 =methyl, the associated double bind is (E)- or (Z)-configured. Furthermore, methods for producing compounds of formula (A) and the use of corresponding compounds as fragrance and/or flavouring substances are described.

  描述了公式(A)的化合物，其中独立地，对于基团R和R1，以下情况适用：R为甲基或乙基，R1为氢或甲基，其中蜿蜒线表示对于R1=甲基，相关的双键为(E)-或(Z)-构型。此外，还描述了制备公式(A)化合物的方法以及相应化合物作为香料和/或调味物质的用途。
• [EN] SECO-AMBRAKETALS<br/>[FR] SECO-AMBRACÉTALS
  申请人：SYMRISE AG

  公开号：WO2022058021A1

  公开（公告）日：2022-03-24

  The present invention primarily relates to compounds of formula (I) and compositions comprising one, two, three or more compound(s) of formula (I) or consisting of two, three or more compound(s) of formula (I). The invention further relates to methods for producing a compound of formula (I) or a composition as defined herein, the use of a compound of formula (I) as defined herein as a fragrance substance, the use of a composition as defined herein as a fragrance substance mixture and the use of a compound of formula (I) or a composition as defined herein for imparting, modifying and/or enhancing one or more olfactory notes selected from the group consisting of the notes ambergris, woody and animalic. Moreover, the present invention relates to fragrance substance compositions and perfumed products as defined herein, methods for producing a perfumed product, methods for perfuming a product and methods for perfuming hair, skin, textile fibres, surfaces and/or ambient air.

  本发明主要涉及式（I）的化合物和包含一个、两个、三个或更多式（I）的化合物或由两个、三个或更多式（I）的化合物组成的组合物。本发明还涉及制备式（I）的化合物或本文所定义的组合物的方法，将本文所定义的式（I）的化合物用作香料物质，将本文所定义的组合物用作香料物质混合物，以及将本文所定义的式（I）的化合物或组合物用于赋予、修改和/或增强选自琥珀香、木质香和动物香等气味音符中的一个或多个气味音符。此外，本发明还涉及香料物质组合物和本文所定义的带香产品，制备带香产品的方法，给产品加香的方法以及给头发、皮肤、纺织纤维、表面和/或环境空气加香的方法。
• [EN] MUGUET TYPE FRAGRANCE COMPOUNDS<br/>[FR] COMPOSÉS DE PARFUM DE TYPE MUGUET
  申请人：SYMRISE AG

  公开号：WO2022058019A1

  公开（公告）日：2022-03-24

  The present invention primarily relates to compounds of formula (I) as defined herein and to compositions comprising one, two, three or more compounds of formula (I) as defined herein, or consisting of two, three or more compounds of formula (I) as defined herein. The invention further relates to methods for producing compounds of formula (I) (or (Ia) or (Ib)), to the use of compounds of formula (I) as fragrance substances and the use of compositions comprising a compound of formula (I) or consisting of compounds of formula (I) as fragrance substance mixtures. It further relates to fragrance substance compositions comprising or consisting of compounds or compositions as defined herein and one or more additional fragrance substances, to perfumed products comprising compounds or compositions or fragrance substance compositions as defined herein, to methods for producing perfumed products as defined herein and to methods for perfuming hair, skin, textile fibres, surfaces and/or ambient air.

  本发明主要涉及公式（I）所定义的化合物和包含一种、两种、三种或更多公式（I）所定义的化合物的组合物，或由两种、三种或更多公式（I）所定义的化合物组成的组合物。本发明还涉及制备公式（I）（或（Ia）或（Ib））化合物的方法，将公式（I）化合物用作香料物质的用途，以及包含公式（I）化合物或由公式（I）化合物组成的香料物质混合物的组合物的用途。它还涉及香料物质组合物，其中包括或仅包括如上所定义的化合物或组合物以及一个或多个额外的香料物质，以及包含如上所定义的化合物或组合物或香料物质组合物的香水产品，制备如上所定义的香水产品的方法以及对头发、皮肤、纺织纤维、表面和/或环境空气进行香氛处理的方法。
• 3,6-Disubstituted Azabicyclo (3.1.0) Hexane Derivatives as Muscarinic Receptor Antagonists
  申请人：Salman Mohammad

  公开号：US20080319043A1

  公开（公告）日：2008-12-25

  The present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

  本发明通常涉及抗胆碱能受体拮抗剂，这些拮抗剂在其他用途中可用于治疗通过胆碱能受体介导的呼吸系统、泌尿系统和消化系统的各种疾病。本发明还涉及揭示化合物的制备过程、含有揭示化合物的制药组合物以及通过胆碱能受体治疗疾病的方法。
• Novel Specific Caspase-10 Inhibitors
  申请人：Lardy Claude

  公开号：US20080255173A1

  公开（公告）日：2008-10-16

  The invention relates to compounds of the general formula (I), and to their use as caspase-10 inhibitors, especially for the treatment of diabetic retinopathy.

  本发明涉及通式(I)的化合物及其作为caspase-10抑制剂的用途，尤其是用于治疗糖尿病视网膜病变。