benzyl 4-cyanophenethylcarbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl 4-cyanophenethylcarbamate
• 英文别名: Benzyl [2-(4-cyanophenyl)ethyl]carbamate；benzyl N-[2-(4-cyanophenyl)ethyl]carbamate
• 化学式: C₁₇H₁₆N₂O₂
• 分子量: 280.326
• InChiKey: GHUVBLLCURIVLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  benzyl 4-cyanophenethylcarbamate 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 生成 对氰基苯乙胺
  参考文献：
  名称：

  [EN] TRIAZOLOTRIAZINE DERIVATIVES AS A2A RECEPTOR ANTAGONISTS
  [FR] DÉRIVÉS DE TRIAZOLOTRIAZINE EN TANT QU'ANTAGONISTES DU RÉCEPTEUR A2A

  摘要：

  本发明提供了公式（1）的三唑三嗪衍生物作为A2A受体拮抗剂。公式（1）的化合物和包括这些化合物的药物组合物可用于治疗与A2A受体过度功能有关的疾病，如某些类型的癌症。该发明揭示了公式（1）的化合物和制备这些化合物的方法。

  公开号：

  WO2020002968A1
• 作为产物：
  描述：

  乙烯基氨基甲酸苄酯 在 palladium diacetate 敌噁磷 、 caesium carbonate 作用下， 以 水 、 甲苯 为溶剂， 反应 12.0h， 生成 benzyl 4-cyanophenethylcarbamate
  参考文献：
  名称：

  β-Aminoethyltrifluoroborates:  Efficient Aminoethylations via Suzuki−Miyaura Cross-Coupling

  摘要：

  A set of phenethylamines has been successfully prepared via Suzuki-Miyaura cross-coupling of diverse potassium beta-aminoethyltrifluoroborates with aryl halides. The potassium beta-aminoethyltrifluoroborates were easily prepared via hydroboration of enamine and enamide precursors.

  DOI：

  10.1021/ol062610v

文献信息

• Novel bradykinin-B1 antagonists, process for their preparation and their use as medicaments
  申请人：Kauffmann-Hefner Iris

  公开号：US20060100219A1

  公开（公告）日：2006-05-11

  The present invention provides bradykinin-B1 antagonists of the formula in which A, Ar, G, Q, R 1 and R 4 are as defined in claim 1 , their enantiomers, their diastereomers, their mixtures and their salts, in particular their physiologically acceptable salts with organic or inorganic acids or bases having useful properties, their preparation, medicaments comprising the pharmacologically effective compounds, their preparation and their use.

  本发明提供了符合以下公式的激肽B1拮抗剂，其中A、Ar、G、Q、R1和R4如权利要求1中定义，它们的对映体、非对映体异构体、混合物和盐，特别是具有有用性能的与有机或无机酸或碱形成的生理上可接受的盐，它们的制备、包含药理有效化合物的药物、它们的制备和它们的用途。
• A novel, one-step method for the conversion of primary alcohols into carbamate-protected amines
  作者：Michael R. Wood、June Y. Kim、Kathy M. Books

  DOI：10.1016/s0040-4039(02)00659-7

  日期：2002.5

  A novel process for the one-step conversion of primary alcohols into carbamate-protected amines has been developed using a modified Burgess reagent. Although this letter mainly focuses on the conversion of alcohols into the corresponding Cbz-protected amines, the potential for extending this process to a wide range of carbamates has also been demonstrated. A detailed catalytic cycle has been proposed

  使用改性的伯吉斯试剂已经开发出一种将伯醇一步转化为氨基甲酸酯保护的胺的新方法。尽管这封信主要集中在将醇转化为相应的Cbz保护的胺上，但也证明了将该方法扩展到广泛的氨基甲酸酯的潜力。已经提出了详细的催化循环。在探索这种新试剂的范围时，已经观察到并合理化了N-芳基哌啶至N-芳基吡咯烷重排。
• Bradykinin-B1 antagonists, process for their preparation and their use as medicaments
  申请人：Boehringer Ingelheim International GmbH

  公开号：US07291642B2

  公开（公告）日：2007-11-06

  The present invention provides bradykinin-B1 antagonists of the formula in which A, Ar, G, Q, R1 and R4 are as defined in claim 1, their enantiomers, their diastereomers, their mixtures and their salts, in particular their physiologically acceptable salts with organic or inorganic acids or bases having useful properties, their preparation, medicaments comprising the pharmacologically effective compounds, their preparation and their use.

  本发明提供了公式中A、Ar、G、Q、R1和R4如权利要求1所定义的Bradykinin-B1拮抗剂，它们的对映体、二对映异构体、混合物和盐，特别是具有有用性质的有机或无机酸或碱的生理上可接受的盐，它们的制备，包含药理有效化合物的药物、它们的制备和使用。
• Scope of the Suzuki−Miyaura Aminoethylation Reaction Using Organotrifluoroborates
  作者：Gary A. Molander、Ludivine Jean-Gérard

  DOI：10.1021/jo7015955

  日期：2007.10.1

  Potassium beta-aminoethyltrifluoroborates were prepared in good yields via hydroboration of the corre- sponding enecarbamates using the Snieckus hydroborating reagent. A wide variety of phenethylamines containing a potentially free primary amine after appropriate deprotection have been successfully prepared in good yield using these organotrifluoroborates as partners in Suzuki-Miyaura coupling with aryl bromides, iodides, and triflates.
• TRIAZOLOTRIAZINE DERIVATIVES AS A2A RECEPTOR ANTAGONISTS
  申请人：Zhejiang Vimgreen Pharmaceuticals, Ltd

  公开号：EP3814355A1

  公开（公告）日：2021-05-05