1-(5'-fluoro-4'-hydroxypentyl)-cytosine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(5'-fluoro-4'-hydroxypentyl)-cytosine
• 英文别名: 4-Amino-1-(5-fluoro-4-hydroxy-pentyl)pyrimidin-2-one；4-amino-1-(5-fluoro-4-hydroxypentyl)pyrimidin-2-one
• 化学式: C₉H₁₄FN₃O₂
• 分子量: 215.227
• InChiKey: OZZFOWOZIKGUSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  胞嘧啶 、 1-fluoro-5-iodopentan-2-yl acetate 在 CsCO₃ 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以73%的产率得到1-(5'-fluoro-4'-hydroxypentyl)-cytosine
  参考文献：
  名称：

  Fluorinated Carbaacyclonucleosides: Synthesis and Evaluation of Antiviral Activity

  摘要：

  Two series of fluoroacyclic nucleosides were synthesised by condensation of nucleic acid bases with substituted fluoropentanes. 1-(5'-Fluoro-4'-hydroxypentyl)-cytosine showed a modest activity against cytomegalovirus (MIC(50): 12-15 mu g/ml). All the other compounds were inactive against all the viruses tested.

  DOI：

  10.1080/15257779508010714

文献信息

• Fluorinated Carbaacyclonucleosides: Synthesis and Evaluation of Antiviral Activity
  作者：Maureen Lewis、T. Brian H. McMurry、Erik De Clercq

  DOI：10.1080/15257779508010714

  日期：1995.11

  Two series of fluoroacyclic nucleosides were synthesised by condensation of nucleic acid bases with substituted fluoropentanes. 1-(5'-Fluoro-4'-hydroxypentyl)-cytosine showed a modest activity against cytomegalovirus (MIC(50): 12-15 mu g/ml). All the other compounds were inactive against all the viruses tested.