tris(2-hydroxyethyl)ammonium L-threoninate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tris(2-hydroxyethyl)ammonium L-threoninate
• 英文别名: [TEAH]⁺[Thr]^-；(2S,3R)-2-amino-3-hydroxybutanoic acid;2-[bis(2-hydroxyethyl)amino]ethanol
• 化学式: C₄H₉NO₃*C₆H₁₅NO₃
• 分子量: 268.31
• InChiKey: MGDMMYCNPIKVMH-RCROYASPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.96
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  148
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  三乙醇胺 、 L-苏氨酸 以 水 为溶剂， 反应 12.0h， 以98%的产率得到tris(2-hydroxyethyl)ammonium L-threoninate
  参考文献：
  名称：

  氨基酸离子液体作为添加剂在植物材料超声辅助提取中的应用

  摘要：

  本研究的目的是通过超声辅助提取 (IL-UAE) 法测定使用离子液体水溶液获得的石松、石松和续断水提物的抗氧化活性。三乙醇铵盐 [TEAH] + [AA] -选择了四种疏水性不同的氨基酸——异亮氨酸——Ile、蛋氨酸——Met、苏氨酸——Thr和精氨酸——Arg作为离子液体，因为它们是基于氨基酸等天然、生物可再生的原料，并且含有三乙醇胺的药学和化妆品可接受的抗衡离子。合成了三乙醇铵盐，通过光谱法（NMR 和 FT-IR）鉴定并通过热法（DSC 和 TGA）表征。将 2.5% w/v 三乙醇铵氨基酸盐水溶液用作溶剂并结合超声辅助萃取 (UAE)。使用 DPPH、FRAP 和 CUPRAC 测定法进行抗氧化性能的估计。使用 Folin-Ciocalteu 试剂测量总多酚含量。结果表明，使用 [TEAH]与纯水提取物相比， + [Thr] -或 [TEAH] + [Met] -水溶液增加了提取物的抗氧化活性。使用[TEAH]

  DOI：

  10.1039/d1ra03840k

文献信息

• METHOD AND COMPOSITION FOR PROVIDING CONTROLLED DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES
  申请人：Verdegem Peter J. E.

  公开号：US20080305096A1

  公开（公告）日：2008-12-11

  A method of providing controlled release of a biologically active substance within a subject's digestive system. The biologically active substance is administered concurrently with one or more soluble fibers in an oral dosage unit. The soluble fibers interact with the biologically active substance within the subject's digestive system to moderate and control the release of the biologically active substances in the subject's bloodstream. This provides more constant blood concentrations of the biologically active substances. The amount of soluble fibers in the oral dosage unit is greater than 40% by weight, and in some cases greater than 50% by weight of the oral dosage unit. The oral dosage unit typically contains from about 1 to 15g of soluble fiber, and in some cases from about 3 to 5g of soluble fiber. The biologically active substance may contain phytonutrients that promote the subject's cardiovascular system, immune system, or weight management.
• METHOD OF CONTROLLING BLOOD SUGAR LEVELS, INSULIN LEVELS, CHOLESTEROL LEVELS, BODY FAT LEVELS, AND BODY WEIGHT BY ADMINISTERING A NUTRIENT FIBER MATRIX
  申请人：Hughes Stewart F.

  公开号：US20100074969A1

  公开（公告）日：2010-03-25

  A nutrient fiber matrix and associated methods that help control blood sugar levels is described. The matrix can control blood sugar in a variety of ways. In one possible example, the matrix blocks carbohydrates in a manner that reduces the body's ability to take the carbohydrates into its cells. In another example, the matrix acts to increase a person's energy level and feelings of satiety. Thus, the matrix can reduce the person's desire to consume more food and, thereby, help the person to keep from increasing his or her blood sugar levels by eating more. In still another example, the fiber matrix helps sugars to be absorbed over a longer period of time so as to smooth out and prevent spikes in blood sugar levels.
• [EN] METHOD AND COMPOSITION FOR PROVIDING CONTROLLED DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES<br/>[FR] PROCÉDÉ ET COMPOSITION DE FOURNITURE D'UNE DISTRIBUTION RÉGULÉE DE SUBSTANCES BIOLOGIQUEMENT ACTIVES
  申请人：UNICITY INTERNATIONAL INC

  公开号：WO2008154294A1

  公开（公告）日：2008-12-18

  [EN] A method of providing controlled release of a biologically active substance within a subject's digestive system. The biologically active substance is administered concurrently with one or more soluble fibers in an oral dosage unit. The soluble fibers interact with the biologically active substance within the subject's digestive system to moderate and control the release of the biologically active substances in the subject's bloodstream. This provides more constant blood concentrations of the biologically active substances. The amount of soluble fibers in the oral dosage unit is greater than 40% by weight, and in some cases greater than 50% by weight of the oral dosage unit. The oral dosage unit typically contains from about 1 to 15g of soluble fiber, and in some cases from about 3 to 5g of soluble fiber. The biologically active substance may contain phytonutrients that promote the subject's cardiovascular system, immune system, or weight management.
  [FR] L'invention concerne un procédé de fourniture d'une libération régulée d'une substance biologiquement active dans le système digestif d'un sujet. La substance biologiquement active est administrée simultanément avec une ou plusieurs fibres solubles en une dose orale. Les fibres solubles interagissent avec la substance biologiquement active dans le système digestif du sujet pour modérer et réguler la libération de substances biologiquement actives dans le courant sanguin du sujet. Cela donne des concentrations dans le sang plus constantes des substances biologiquement actives. La quantité de fibres solubles dans la dose orale est supérieure à 40 % en poids et, dans certains cas, supérieure à 50 % en poids de la dose orale. La dose orale contient typiquement environ 1 à 15 g de fibre soluble et, dans certains cas, environ 3 à 5 g de fibre soluble. La substance biologique active peut contenir des phytonutriments qui favorisent le système cardiovasculaire, le système immunitaire ou la gestion du poids du sujet.
• [EN] METHOD OF CONTROLLING BLOOD SUGAR LEVELS, INSULIN LEVELS, CHOLESTEROL LEVELS, BODY FAT LEVELS, AND BODY WEIGHT BY ADMINISTERING A NUTRIENT FIBER MATRIX<br/>[FR] MÉTHODE DE RÉGULATION DES TAUX SANGUINS DE SUCRE, D'INSULINE, DE CHOLESTÉROL, DES TAUX DE GRAISSE DANS LE CORPS, ET DU POIDS CORPOREL PAR ADMINISTRATION D'UNE MATRICE DE FIBRES NUTRITIVES
  申请人：HUGHES STEWART F

  公开号：WO2010033915A2

  公开（公告）日：2010-03-25

  A nutrient fiber matrix and associated methods that help control blood sugar levels is described. The matrix can control blood sugar in a variety of ways. In one possible example, the matrix blocks carbohydrates in a manner that reduces the body's ability to take the carbohydrates into its cells. In another example, the matrix acts to increase a person's energy level and feelings of satiety. Thus, the matrix can reduce the person's desire to consume more food and, thereby, help the person to keep from increasing his or her blood sugar levels by eating more. In still another example, the fiber matrix helps sugars to be absorbed over a longer period of time so as to smooth out and prevent spikes in blood sugar levels.
• The application of amino acid ionic liquids as additives in the ultrasound-assisted extraction of plant material
  作者：Barbara Roman、Anna Muzykiewicz-Szymańska、Paula Ossowicz-Rupniewska、Adam Klimowicz、Ewa Janus

  DOI：10.1039/d1ra03840k

  日期：——

  study was to determine the antioxidant activity of the aqueous extracts from Lycopodium clavatum, Cetraria islandica and Dipsacus fullonum obtained using aqueous solutions of ionic liquids by the ultrasound-assisted extraction (IL-UAE) method. Triethanolammonium salts [TEAH]+[AA]− of four amino acids of different hydrophobicity – isoleucine – Ile, methionine – Met, threonine – Thr and arginine – Arg

  本研究的目的是通过超声辅助提取 (IL-UAE) 法测定使用离子液体水溶液获得的石松、石松和续断水提物的抗氧化活性。三乙醇铵盐 [TEAH] + [AA] -选择了四种疏水性不同的氨基酸——异亮氨酸——Ile、蛋氨酸——Met、苏氨酸——Thr和精氨酸——Arg作为离子液体，因为它们是基于氨基酸等天然、生物可再生的原料，并且含有三乙醇胺的药学和化妆品可接受的抗衡离子。合成了三乙醇铵盐，通过光谱法（NMR 和 FT-IR）鉴定并通过热法（DSC 和 TGA）表征。将 2.5% w/v 三乙醇铵氨基酸盐水溶液用作溶剂并结合超声辅助萃取 (UAE)。使用 DPPH、FRAP 和 CUPRAC 测定法进行抗氧化性能的估计。使用 Folin-Ciocalteu 试剂测量总多酚含量。结果表明，使用 [TEAH]与纯水提取物相比， + [Thr] -或 [TEAH] + [Met] -水溶液增加了提取物的抗氧化活性。使用[TEAH]