乙酮,2-氯-1-(1,3,5-三甲基-1H-吡唑-4-基)- | 107447-22-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 乙酮,2-氯-1-(1,3,5-三甲基-1H-吡唑-4-基)-
• 中文别名: 1-(2-羟基乙基)-3,5,6-三甲基-2(1H)-吡嗪酮
• 英文名称: 8-Methyl-6,9-diazaspiro[4.5]decane-7,10-dione
• CAS: 107447-22-3
• 化学式: C₉H₁₄N₂O₂
• 分子量: 182.22
• InChiKey: LTRSPDHUDXWHRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

文献信息

• PHENYLACETIC ACID INHIBITORS OF CYCLOOXYGENASE
  申请人：Gant Thomas G.

  公开号：US20100119508A1

  公开（公告）日：2010-05-13

  The present invention relates to new phenylacetic acid inhibitors of cyclooxygenase activity, pharmaceutical compositions thereof, and methods of use thereof.
• [EN] ALAPTIDE : METHODS OF EFFECTING ITS SOLUBILITY, MEMBRANE PERMEATION AND PHARMACEUTICAL COMPOSITIONS FOR HUMAN AND/OR VETERINARY APPLICATIONS<br/>[FR] ALAPTIDE : PROCÉDÉ DE SOLUBILISATION, ET DE MODIFICATION DE LA PERMÉATION MEMBRANAIRE, ET COMPOSITIONS PHARMACEUTIQUES POUR APPLICATIONS HUMAINES ET/OU VÉTÉRINAIRES
  申请人：UNIV VETERINARY AND PHARMACEUTICAL SCIENCES BRNO FACULTY OF PHARMACY

  公开号：WO2014019556A1

  公开（公告）日：2014-02-06

  The invention deals with the way of effecting the solubility of alaptide by the addition of low- molecular or high-molecular compounds or by generation of nanoparticles. These technological modifications of alaptide influence the penetration of alaptide through biological membranes, including skin. Alaptide modified in this way can be also used for preparation of pharmaceutical compositions (formulations), which can, in their turn, influence the absorption of alaptide.