1,9-bis(2'-pyridyl)-2,5,8-triazanonane trihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,9-bis(2'-pyridyl)-2,5,8-triazanonane trihydrochloride
• 英文别名: N'-(pyridin-2-ylmethyl)-N-[2-(pyridin-2-ylmethylamino)ethyl]ethane-1,2-diamine;hydrochloride
• 化学式: C₁₆H₂₃N₅*3ClH
• 分子量: 394.775
• InChiKey: MPTQFPJAZLKZES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.37
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  61.9
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  cobalt(II) nitrate hexahydrate 、 1,9-bis(2'-pyridyl)-2,5,8-triazanonane trihydrochloride 在 氢氧化钾 作用下， 以 水 为溶剂， 生成 cobalt(2+);N'-(pyridin-2-ylmethyl)-N-[2-(pyridin-2-ylmethylamino)ethyl]ethane-1,2-diamine
  参考文献：
  名称：

  Harris, Wesley R.; McLendon, George L.; Martell, Arthur E., Inorganic Chemistry, 1980, vol. 19, # 1, p. 21 - 26

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N'-bis(2-aminoethyl)ethane-1,2-diamine dihydrochloride 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 18.0h， 生成 1,9-bis(2'-pyridyl)-2,5,8-triazanonane trihydrochloride
  参考文献：
  名称：

  Effects of Some Chelating Agents on Urinary Copper Excretion by the Rat

  摘要：

  In order to estimate the potential advantages of new chelating agents which can enhance copper excretion in the chronic copper intoxication arising in Wilson's disease, the relative ability of nine chelating agents to induce the urinary excretion of copper was compared with that of D-penicillamine (DPA) and triethylenetetramine . 2HCl (TRIEN), all given ip at 1 mmol/kg to male Sprague-Dawley rats. The compounds examined were as follows: tris(2-aminoethyl)-amine . 3HCl (TREN), tetraethylenepentamine . 5HCl (TETREN), pentaethylenehexamine . 6HCl (PENTEN), 1,4,7,11-tetraazaundecane . 4HCl (TAUD), 1,5,8,12-tetraazadodecane . 4KCl (TADD), 1-N-benzyltriethylenetetramine . 4HCl (BzTT), 4,7,10,13-tetraazatridecanoic acid . 2H(2)SO(4) (TTPA), 1,10-bis(2-pyridylmethyl)-1,4,7,10-tetraazadecane . 4HCl (BPTETA), and N,N-bis(2-pyridylmethyl)-4-(aminomethyl)benzoic acid (4ABA). Of these, BzTT, TTPA, and 4ABA are new chelating agents not previously reported. The factors by which these chelating agents enhanced copper excretion over control (untreated) levels were as follows: DPA, 7.2; TREN, 1.6; TRIEN, 4.0; TETREN, 10.1; PENTEN, 7.8; TAUD, 7.8; TADD, 2.6; TTPA, 5.6; BzTT, 1.8; and 4ABA, 5.5. The results indicate that it may well be possible to develop additional chelating agents which are equal or superior to those now used in the treatment of Wilson's disease, as well as structural types whose immunological properties may be significantly different from DPA or TRIEN, the compounds currently used in the clinic for this disorder.

  DOI：

  10.1021/tx00049a007

文献信息

• Copper(II)-Sulfur Interactions in Pyridine- and Imidazole-containing Disulfide Complexes. Syntheses, Spectra, and Solution Equilibria
  作者：Osamu Yamauchi、Hiroko Seki、Toshiya Shoda

  DOI：10.1246/bcsj.56.3258

  日期：1983.11

  neutral–alkaline solution. A stable 1 : 1 copper(II) complex, Cu(IMAD)(ClO4)2·H2O, was isolated as crystals from aqueous solution, whereas a binuclear complex, Cu2(PMAD)Cl4, was obtained as crystals in ethanol. The Cu(II)–IMAD systems exhibit a single d-d peak at 585 nm indicative of a CuN4 chromophore but no charge transfer (CT) band in the region 300–900 nm. The other Cu(II)–disulfide systems exhibit

  已经对含吡​​啶环、喹啉环和咪唑环的二硫化物和相关化合物的铜 (II) 配合物进行了合成、光谱和电位研究，重点是铜 (II)-硫相互作用。在铜 (II)、二硫化物配体 (RCH2NHCH2CH2S–)2 存在下，其中 R=4-咪唑基 (IMAD)、2-吡啶基 (PMAD)、6-甲基-2-吡啶基 (MPAD) 和 2-喹啉基(QMAD)，在酸性溶液中比在中性碱性溶液中更稳定。稳定的 1:1 铜 (II) 配合物 Cu(IMAD)(ClO4)2·H2O 以晶体形式从水溶液中分离出来，而双核配合物 Cu2(PMAD)Cl4 在乙醇中以晶体形式获得。Cu(II)-IMAD 系统在 585 nm 处显示一个单 dd 峰，表明存在 CuN4 发色团，但在 300-900 nm 区域没有电荷转移 (CT) 带。其他 Cu(II)-二硫化物系统在 650 和 ≈850 nm 处显示 dd 带。分别在 pH
• Fuel cells
  申请人：Knuckey Kathryn

  公开号：US09136554B2

  公开（公告）日：2015-09-15

  This invention provides a redox fuel cell comprising an anode and a cathode separated by an ion selective polymer electrolyte membrane; means for supplying a fuel to the anode region of the cell; means for supplying an oxidant to the cathode region of the cell; means for providing an electrical circuit between the anode and the cathode; a non-volatile catholyte solution flowing in fluid communication with the cathode, the catholyte solution comprising a redox mediator which is at least partially reduced at the cathode in operation of the cell, and at least partially regenerated by, optionally indirect, reaction with the oxidant after such reduction at the cathode, and a transition metal complex of a multidentate N-donor ligand as a redox catalyst catalyzing the regeneration of the mediator.

  这项发明提供了一种氧化还原燃料电池，包括由离子选择性聚合物电解质膜分隔的阳极和阴极；用于向电池的阳极区域供应燃料的手段；用于向电池的阴极区域供应氧化剂的手段；在阳极和阴极之间提供电路的手段；与阴极流体通信的非挥发性阴极液体，该阴极液体包括在电池运行中至少部分在阴极上被还原的氧化还原中介体，并在阴极上的此类还原后，通过与氧化剂的（可选间接）反应至少部分再生的过渡金属配合物复合多齿N-供体配体作为催化剂，催化介体的再生。
• The Reactivity of an Iron( <scp>II</scp> )/Iron( <scp>III</scp> ) System with Polyamine Ligands in Ethanol: An Electrochemical Study
  作者：Víctor M. Ugalde‐Saldivar、Martha E. Sosa‐Torres、Ignacio González

  DOI：10.1002/ejic.200390130

  日期：2003.3

  The new ligand L′B 1,9-bis(2′-pyridyl)-5-[(ethoxy-2′-pyridyl)methyl]-2,5,8-triazanon-1-ene} has an imine carbon−nitrogen double bond. This study provides evidence for the nature of the intermediate species during the formation of [FeL′B](BPh4)2. A systematic study was performed based on the evolution of the voltammograms observed after the addition of ligand (LA, LB) or base (LiOEt) to FeIII, FeII solutions

  五齿配体 picdien [LA; 1,9-双(2'-吡啶基)-2,5,8-三氮杂壬烷)]和[Fe(DMSO)6](NO3)3在乙醇中反应后生成六配位配位化合物[FeL'B]2+。该化合物显示出 FeIII 到 FeII 的氧化态变化以及起始配体 LA 的齿数增加。新配体 L'B 1,9-bis(2'-pyridyl)-5-[(ethoxy-2'-pyridyl)methyl]-2,5,8-triazanon-1-ene} 具有亚胺碳-氮双键。该研究为 [FeL'B](BPh4)2 形成过程中中间物种的性质提供了证据。基于将配体 (LA, LB) 或碱 (LiOEt) 添加到 FeIII、FeII 溶液或化学计量金属-配体混合物后观察到的伏安图的演变进行了系统研究（LB 是没有亚胺基团的 L'B） . FeLA3+ 和 FeLA2+ 物质在酸性介质和氮气氛下的稳定性得到证实。发现 FeLB3+
• Novel iron(ii) complexes with hexadentate nitrogen ligands obtained via intramolecular redox reactions
  作者：Víctor Manuel Ugalde-Saldívar、Martha Elena Sosa-Torres、Luis Ortiz-Frade、Sylvain Bernès、Herbert Höpfl

  DOI：10.1039/b100915j

  日期：——

  Two novel complexes: [Fe(L2′)][BPh4]2, 1, and [Fe(L3′)][BPh4]2, 2, with the hexadentate nitrogen ligands, Ln′ = 1,9-bis(2′-pyridyl)-5-[(R-2″-pyridyl)methyl]-2,5,8-triazanon-1-ene, where R = ethoxy for L2′ and methoxy for L3′, were obtained from the iron(III) complex of the pentadentate ligand, L1 = 1,9-bis(2′-pyridyl)-2,5,8-triazanonane. Complexes 1 and 2 were also obtained by making the hexadentate

  两个新的配合物：[铁（L 2'）] [BPH 4 ] 2，1，和的[Fe（L 3'）] [BPH 4 ] 2，2，用六齿氮配体，L Ñ ' = 1,9- -双（2′-吡啶基）-5-[（R-2″-吡啶基）甲基] -2,5,8-三氮杂-1-烯，其中对于L 2'，R =乙氧基，对于L 3'，R =甲氧基，得自五齿配体的铁（III）配合物，L 1 ＝ 1，9-双（2′-吡啶基）-2，5，8-三氮杂壬烷。配合物1和2还通过制备六齿配体获得：1,9-双（2'-吡啶基）-5-[（乙氧基-2'-吡啶基）甲基] -2,5,8-三氮杂壬烷（L 2）和1,9 -双（2'-吡啶基）-5-[（甲氧基-2″-吡啶基）甲基] -2,5,8-三氮杂壬烷（L 3）分别与Fe（III）反应。配合物1和2的结构通过COSY，HMBC，HMQC和NOESY NMR研究进行了表征，并且两种结构也都通过X射线分析得到了证实。在这两种
• Crystal structure of six and seven coordinate manganese(II) complexes with penta and hexadentate pyridylmethyl ligands
  作者：Sanae El Ghachtouli、Aminou Mohamadou、Jean-Pierre Barbier

  DOI：10.1016/j.ica.2005.06.050

  日期：2005.9

  Abstract Two six-coordinated manganese(II) complexes [Mn(pydien)Cl](ClO 4 ) · C 2 H 5 OH ( 1 ), [Mn(pydien)NCS](ClO 4 ) ( 2 ) and two seven-coordinated manganese(II) complexes [Mn(pydado)Cl](ClO 4 ) ( 3 ), [Mn(pydado)NCS](ClO 4 ) ( 4 ) have been obtained using linear penta and hexadentate ligands pydien and pydado (pydien: 1,7-bis(2-pyridylmethyl)-1,4,7-triazaheptane and pydado: 1,10-bis(pyridylmethyl)-1

  摘要两个六配位锰（II）配合物[Mn（pydien）Cl]（ClO 4）·C 2 H 5 OH（1），[Mn（pydien）NCS]（ClO 4）（2）和两个七配位的锰锰（II）配合物[Mn（pydado）Cl]（ClO 4）（3），[Mn（pydado）NCS]（ClO 4）（4）已使用线性五元和六齿配体pydien和pydado（pydien：1 ，7-双（2-吡啶基甲基）-1,4,7-三氮杂庚烷和pydado：1,10-双（吡啶基甲基）-1,10-二氮杂-4,7-二氧杂十二烷）。已经确定了所有化合物的晶体结构。1和3在三斜晶系空间群P 1结晶，2在斜方晶系空间群Pbca中结晶，而4在单斜晶空间群P 2 1 / c中结晶。配合物1和2中的键合阴离子（氯或异硫氰酸根）对六配位锰（II）配合物的几何形状没有影响，而六齿配体（pydado）围绕Mn 2+阳离子的几何形状和包裹方式取决于结合阴