butyl 2-(butoxy(ethyl)phosphinyl)acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: butyl 2-(butoxy(ethyl)phosphinyl)acetate
• 英文别名: butyl 2-(ethylbutoxyphosphinyl)acetate；Butyl 2-[butoxy(ethyl)phosphoryl]acetate
• 化学式: C₁₂H₂₅O₄P
• 分子量: 264.302
• InChiKey: LENNLFHMRNDMDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  butyl 2-(butoxy(ethyl)phosphinyl)acetate 、 乙二醇 在 potassium bis(oxalato)oxotitanate(IV) 作用下， 反应 2.0h， 以98%的产率得到2-hydroxyethyl 2-(ethyl(2-hydroxyethoxy)phosphinyl)acetate
  参考文献：
  名称：

  Process for preparing mono-carboxy-functionalized dialkylphosphinic acids, esters and salts by means of alkylene oxides and use thereof

  摘要：

  通过烯烃（IV）与磷酸源（I）在催化剂A存在下反应形成烷基膦酸、其盐或酯（II），b) 在催化剂B存在下，将所得的烷基膦酸、其盐或酯（II）与式（V）的烯烃氧化物反应，得到单官能化的二烷基膦酸衍生物（VI），c) 在催化剂C存在下，将所得的单官能化的二烷基膦酸衍生物（VI）反应，得到单羧基官能化的二烷基膦酸衍生物（III），其中催化剂A和C为过渡金属和/或过渡金属化合物和/或由过渡金属和/或过渡金属化合物以及至少一种配体组成的催化剂体系，催化剂B为路易斯酸。

  公开号：

  US09085734B2
• 作为产物：
  描述：

  2-(ethyl(hydroxy)phosphinyl)acetic acid 、 正丁醇 以 甲苯 为溶剂， 以89%的产率得到butyl 2-(butoxy(ethyl)phosphinyl)acetate
  参考文献：
  名称：

  Process for preparing mono-carboxy-functionalized dialkylphosphinic acids, esters and salts by means of alkylene oxides and use thereof

  摘要：

  通过烯烃（IV）与磷酸源（I）在催化剂A存在下反应形成烷基膦酸、其盐或酯（II），b) 在催化剂B存在下，将所得的烷基膦酸、其盐或酯（II）与式（V）的烯烃氧化物反应，得到单官能化的二烷基膦酸衍生物（VI），c) 在催化剂C存在下，将所得的单官能化的二烷基膦酸衍生物（VI）反应，得到单羧基官能化的二烷基膦酸衍生物（III），其中催化剂A和C为过渡金属和/或过渡金属化合物和/或由过渡金属和/或过渡金属化合物以及至少一种配体组成的催化剂体系，催化剂B为路易斯酸。

  公开号：

  US09085734B2

文献信息

• Process for preparing mono-carboxy-functionalized dialkylphosphinic acids, esters and salts by means of alkylene oxides and use thereof
  申请人：Hill Michael

  公开号：US09085734B2

  公开（公告）日：2015-07-21

  A process for preparing mono-carboxy-functionalized dialkylphosphinic acids, dialkylphosphinic esters and dialkylphosphinic salts by means of alkylene oxides, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) in the presence of a catalyst A to form an alkylphosphonous acid, its salt or ester (II), b) the resultant alkylphosphonous acid, its salt or ester (II) is reacted with alkylene oxides of the formula (V) in the presence of a catalyst B, to give a mono-functionalized dialkylphosphinic acid derivative (VI), and c) the resultant mono-functionalized dialkylphosphinic acid derivative (VI) is reacted in the presence of a catalyst C to give the mono-carboxy-functionalized dialkylphosphinic acid derivative (III), and the catalysts A and C are transition metals and/or transition-metal compounds and/or catalyst systems which are composed of a transition metal and/or a transition-metal compound and at least one ligand, and the catalyst B is a Lewis acid.

  通过烯烃（IV）与磷酸源（I）在催化剂A存在下反应形成烷基膦酸、其盐或酯（II），b) 在催化剂B存在下，将所得的烷基膦酸、其盐或酯（II）与式（V）的烯烃氧化物反应，得到单官能化的二烷基膦酸衍生物（VI），c) 在催化剂C存在下，将所得的单官能化的二烷基膦酸衍生物（VI）反应，得到单羧基官能化的二烷基膦酸衍生物（III），其中催化剂A和C为过渡金属和/或过渡金属化合物和/或由过渡金属和/或过渡金属化合物以及至少一种配体组成的催化剂体系，催化剂B为路易斯酸。
• Method for Producing Mono-Carboxy-Functionalized Dialkylphosphinic Acids, Esters and Salts Using a Vinyl Ether and the Use Thereof
  申请人：Hill Michael

  公开号：US20110275744A1

  公开（公告）日：2011-11-10

  The invention relates to a method for producing mono-carboxy-functionalized dialkylphosphinic acids, esters and salts using a vinyl ether. The method is characterized by the following steps: a) reacting a phosphinic acid source (I) with olefins (IV) in the presence of a catalyst A to give an alkylphosphonous acid, the salt or the ester (II) thereof, b) reacting the alkylphosphonous acid so obtained, the salt or the ester (II) thereof with a vinyl ether of formula (V) in the presence of a catalyst B to give a mono-functionalized dialkylphosphinic acid derivative (VI) and c) reacting the mono-functionalized dialkylphosphinic acid derivative (VI) so obtained with an oxidant or in the;presence of a catalyst C to give a mono-carboxy-functionalized dialkylphosphinic acid derivative (III), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 are the same or different and independently of each other inter alia represent H, C 1 -C 18 alkyl, C 6 -C 18 aryl, C 6 -C 18 aralkyl, C 6 -C 18 alkylaryl and X and Y are the same or different and independently of each other represent H, C 1 -C 18 alkyl, C 6 -C 18 aryl, C 6 -C 18 aralkyl, C 6 -C 18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogen base and the catalysts A and C are transition metals and/or transition metal compounds and/or catalyst systems which are composed of a transition metal and/or a transition metal compound and at least one ligand, and the catalyst B is a peroxide-forming compound and/or a peroxo compound and/or an azo compound.

  本发明涉及一种利用乙烯醚生产单羧基功能化二烷基膦酸、酯和盐的方法。该方法的特征在于以下步骤：a)在催化剂A的存在下，将膦酸源(I)与烯烃(IV)反应，得到烷基膦酸、盐或其酯(II)；b)在催化剂B的存在下，将所得到的烷基膦酸、盐或其酯(II)与式(V)的乙烯醚反应，得到单官能化的二烷基膦酸衍生物(VI)；c)在氧化剂或催化剂C的存在下，将所得到的单官能化的二烷基膦酸衍生物(VI)反应，得到单羧基功能化的二烷基膦酸衍生物(III)。其中，R1、R2、R3、R4、R5、R6可以相同也可以不同，可以独立地表示H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基，X和Y可以相同也可以不同，可以独立地表示H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基、Mg、Ca、Al、Sb、Sn、Ge、Ti、Fe、Zr、Zn、Ce、Bi、Sr、Mn、Cu、Ni、Li、Na、K和/或质子化氮碱，催化剂A和C是过渡金属和/或过渡金属化合物和/或由过渡金属和/或过渡金属化合物和至少一个配体组成的催化剂体系，催化剂B是过氧化物形成化合物和/或过氧化物和/或偶氮化合物。
• Method for Producing Mono-Carboxy-Functionalized Dialkylphosphinic Acids, Esters and Salts Using a Vinyl Ester of a Carboxylic Acid and the Use Thereof
  申请人：Hill Michael

  公开号：US20110237721A1

  公开（公告）日：2011-09-29

  The invention relates to a method for producing mono-carboxy-functionalized dialkyiphosphinic acids, esters and salts using a vinyl ester of a carboxylic acid. The method is characterized by the following steps: a) reacting a phosphinic acid source (I) with olefins (IV) in the presence of a catalyst A to give an alkylphosphinic acid, the salt or the ester (II) thereof, b) reacting the alkylphosphinic acid so obtained, the salt or the ester (II) thereof with a vinyl ester of a carboxylic acid of formula (V) in the presence of a catalyst B to give a mono-functionalized dialkylphosphinic acid derivative (VI) and c) reacting the mono-functionalized dialkyiphosphinic acid derivative (VI) so obtained in the presence of a catalyst C to give a mono-functionalized dialkylphosphinic acid derivative (VII) and d) reacting the mono-functionalized dialkyiphosphinic acid derivative (VII); with an oxidant or in the presence of a catalyst D to give a mono-carboxy-functionalized dialkylphosphinic acid derivative (III), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 are the same or different and independently of each other inter alia represent H, C 1 -C 18 alkyl, C 6 -C 18 aryl, C 6 -C 18 aralkyl, C 6 -C 18 alkylaryl and X and Y are the same or different and independently of each other represent H, C 1 -C 18 alkyl, C 8 -C 18 aryl, C 6 -C 18 aralkyl, C 6 -C 18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogen base and the catalysts A and D are transition metals and/or transition metal compounds and/or catalyst systems which are composed of a transition metal and/or a transition metal compound and at least one ligand, and the catalyst B is a peroxide-forming compound and/or a peroxo compound and/or an azo compound, and the catalyst C is an acid or a base.

  本发明涉及一种使用羧酸乙烯酯制备单羧基功能化二烷基膦酸、酯和盐的方法。该方法的特点在于以下步骤：a）在催化剂A的存在下，将膦酸源（I）与烯烃（IV）反应，得到烷基膦酸、其盐或酯（II），b）在催化剂B的存在下，将所得的烷基膦酸、其盐或酯（II）与式（V）的羧酸乙烯酯反应，得到单功能化的二烷基膦酸衍生物（VI），c）在催化剂C的存在下，将所得的单功能化的二烷基膦酸衍生物（VI）反应，得到单功能化的二烷基膦酸衍生物（VII），d）在氧化剂的存在下或在催化剂D的存在下，将所得的单功能化的二烷基膦酸衍生物（VII）反应，得到单羧基功能化的二烷基膦酸衍生物（III），其中R1、R2、R3、R4、R5、R6相同或不同，独立地表示H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基，X和Y相同或不同，独立地表示H、C1-C18烷基、C8-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基、Mg、Ca、Al、Sb、Sn、Ge、Ti、Fe、Zr、Zn、Ce、Bi、Sr、Mn、Cu、Ni、Li、Na、K和/或质子化氮碱，催化剂A和D是过渡金属和/或过渡金属化合物和/或由过渡金属和/或过渡金属化合物和至少一种配体组成的催化剂体系，催化剂B是过氧化物形成化合物和/或过氧化物和/或偶氮化合物，催化剂C是酸或碱。
• Process for Preparing Mono-Carboxy-Functionalized Dialkylphosphinic Acids, Esters and Salts by Means of Alkylene Oxides and Use Thereof
  申请人：Hill Michael

  公开号：US20110245385A1

  公开（公告）日：2011-10-06

  The invention relates to a process for preparing mono-carboxy-functionalized dialkylphosphinic acids, dialkylphosphinic esters and dialkylphosphinic salts by means of alkylene oxides, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) in the presence of a catalyst A to form an alkylphosphonous acid, its salt or ester (II), b) the resultant alkylphosphonous acid, its salt or ester (II) is reacted with alkylene oxides of the formula (V) in the presence of a catalyst B, to give a mono-functionalized dialkylphosphinic acid derivative (VI), and c) the resultant mono-functionalized dialkylphosphinic acid derivative (VI) is reacted in the presence a catalyst C to give the mono-carboxy-functionalized dialkylphosphinic acid derivative (III), where R 1 ,R 2 ,R 3 ,R 4 ,R 5 , and R 6 are identical or different and independently of one another are inter alia H, C 1 -C 18 -alkyl, C 6 -C 18 -aryl, C 6 -C 18 -aralkyl or C 6 -C 18 -alkylaryl, and X and Y are identical or different and independently of one another are H, C 1 -C 18 -alkyl, C 6 -C 18 -aryl, C 6 -C 18 -aralkyl, C 6 -C 18 -alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogen base, and the catalysts A and C are transition metals and/or transition-metal compounds and/or catalyst systems which are composed of a transition metal and/or a transition-metal compound and at least one ligand, and the catalyst B is a Lewis acid.

  本发明涉及一种通过使用环氧烷制备单羧基功能化二烷基膦酸、二烷基膦酸酯和二烷基膦酸盐的方法，其特征在于a）在催化剂A的存在下，将膦酸源（I）与烯烃（IV）反应，形成烷基膦酸、其盐或酯（II），b）在催化剂B的存在下，将所得的烷基膦酸、其盐或酯（II）与式（V）的环氧烷反应，得到单功能化的二烷基膦酸衍生物（VI），c）在催化剂C的存在下，将所得的单功能化的二烷基膦酸衍生物（VI）反应，得到单羧基功能化的二烷基膦酸衍生物（III），其中R1、R2、R3、R4、R5和R6相同或不同，且独立地是H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基或C6-C18烷基芳基，X和Y相同或不同，且独立地是H、C1-C18烷基、C6-C18芳基、C6-C18芳基烷基、C6-C18烷基芳基、Mg、Ca、Al、Sb、Sn、Ge、Ti、Fe、Zr、Zn、Ce、Bi、Sr、Mn、Cu、Ni、Li、Na、K和/或质子化的氮碱基，催化剂A和C是过渡金属和/或过渡金属化合物和/或由过渡金属和/或过渡金属化合物和至少一个配体组成的催化剂体系，而催化剂B是路易斯酸。
• NON-PHTHALATE COMPOUNDS AS ELECTRON DONORS FOR POLYOLEFIN CATALYSTS
  申请人：Formosa Plastics Corporation, U.S.A.

  公开号：EP2969201A2

  公开（公告）日：2016-01-20