辛烷-1,7-二胺 | 62577-98-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 辛烷-1,7-二胺
• 英文名称: 1,7-diaminooctane
• 英文别名: Octane-1,7-diamine
• CAS: 62577-98-4
• 化学式: C₈H₂₀N₂
• mdl: MFCD19207187
• 分子量: 144.26
• InChiKey: ADWMBDUGYBDVAS-UHFFFAOYSA-N

物化性质

• 沸点：
  229.0±8.0 °C(Predicted)
• 密度：
  0.857±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-三氟甲氧基苯甲酰氟 、 辛烷-1,7-二胺 在 potassium carbonate 、 氯仿 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 N,N'-(1-Methylheptamethylene)bis(4-trifluoromethoxybenzamide)
  参考文献：
  名称：

  N,N'-Heptamethylenebis(4-methoxybenzamide)

  摘要：

  4-(Q-O)-4'-R.sub.1 -N,N'-烷基双苯甲酰胺，N,N'-烷基双(3,4-二甲氧基苯甲酰胺)或N,N'-烷基双[4-(低碳氧基)苯甲酰胺]，具有内分泌学特性，其中Q是低碳基，低碳氧基烷基，低碳烯基，卤代低碳基，卤代低碳烯基，低环烷基，苯基和BN-(低碳基)其中BN是二(低碳基)氨基或具有五至七个环原子的饱和N-杂环基团，烷基在其两个连接链之间至少有五个碳原子，R.sub.1是Q-O-，氢，低碳氧基，低碳基，卤素，苄氧基，羟基，二(低碳基)氨基，硝基，氨基或三卤甲基，通常通过将适当的二胺或N-(氨基烷基)-苯甲酰胺与相应的苯甲酰卤反应制备而成。

  公开号：

  US04009208A1
• 作为产物：
  描述：

  2-(4-戊炔氧基)四氢-2H-吡喃 在 platinum(IV) oxide 六甲基磷酰三胺 、 正丁基锂 、 sodium azide 、 stones 、 氢气 、 4-甲基苯磺酸吡啶 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 水 、 二甲基亚砜 为溶剂， 反应 7.25h， 生成 辛烷-1,7-二胺
  参考文献：
  名称：

  Branched-chain and unsaturated 1,7-Diaminoheptane derivatives as deoxyhypusine synthase inhibitors

  摘要：

  Deoxyhypusine synthase catalyzes the first step in the posttranslational biosynthesis of the unusual amino acid hypusine [N-epsilon-(4-amino-2-hydroxybutyl)lysine] in eukaryotic translation initiation factor 5A (eIF-SA). eIF-SA and its single hypusine residue are essential for cell proliferation. Two series of 1,7-diaminoheptane derivatives were prepared and tested as inhibitors of human deoxyhypusine synthase. These include branched-chain saturated derivatives and both branched- and straight-chain unsaturated derivatives providing size and positional variation in branching and different torsional constraints. Of the branched-chain compounds, 7-amino-1-guanidinooctane (39) proved to be the most potent inhibitor in vitro (IC50, 34 nM), while 1,7-diamino-trans-hept-3-ene (20a) displayed the greatest inhibition (IC50, 0.7 mu M) among the unsaturated compounds. Compound 39 also provided effective inhibition of hypusine production in Chinese hamster ovary cells in culture. Considerations of the in vitro inhibition data reported here, along with earlier findings, allowed some speculation concerning the conformation of the substrate spermidine during its productive interaction at the active site of deoxyhypusine synthase. Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)10030-x

文献信息

• Dendrimers as molecular translocators
  申请人：Goodman Murray

  公开号：US20060216265A1

  公开（公告）日：2006-09-28

  Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

  转运分子包括一种树枝状聚合物和一种生物活性分子。这些转运分子的树枝状聚合物包括至少一个胍基团、至少一个质子化的胍基团、至少一个保护的胍基团、至少一个酰胺基团、至少一个质子化的酰胺基团、至少一个保护的酰胺基团、至少一个脲基团、至少一个质子化的脲基团、至少一个保护的脲基团、至少一个硫脲基团、至少一个质子化的硫脲基团，或至少一个保护的硫脲基团。生物活性分子与树枝状聚合物结合。一种增加药物生物利用度的方法包括将药物与本发明的树枝状聚合物结合。
• Dendrimers as Molecular Translocators
  申请人：Goodman Murray

  公开号：US20080221020A1

  公开（公告）日：2008-09-11

  Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

  运输分子包括一个树状分子和一个生物活性分子。这种运输分子的树状分子包括至少一个鸟氨酸基团，至少一个质子化的鸟氨酸基团，至少一个保护的鸟氨酸基团，至少一个酰胺基团，至少一个质子化的酰胺基团，至少一个保护的酰胺基团，至少一个尿素基团，至少一个质子化的尿素基团，至少一个保护的尿素基团，至少一个硫脲基团，至少一个质子化的硫脲基团，或者至少一个保护的硫脲基团。生物活性分子与树状分子结合。一种增加药物生物利用度的方法包括将药物与本发明的树状分子结合。
• Polyetherimide-polyphenylene ether blends
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0091118A1

  公开（公告）日：1983-10-12

  Disclosed are blends of (a) a polyetherimide and (b) a polyphenylene ether. The components of the blend are generally compatible and the blends exhibit good impact strength as well as good mechanical properties. The blends are suitable for forming insulative films on substrates and for the manufacture of filaments, fibers, coatings, molded articles and the like.

  所公开的是 (a) 聚醚酰亚胺和 (b) 聚苯醚的混合物。混合物的各组分一般具有相容性，混合物具有良好的抗冲击强度和机械性能。这种混合物适用于在基材上形成绝缘薄膜，也适用于制造长丝、纤维、涂层、模塑制品等。
• Blends of polyetherimides and organopolysiloxane-polycarbonate block copolymers
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0122308A1

  公开（公告）日：1984-10-24

  Disclosed are blends of (a) a polyetherimide and (b) an organopolysiloxane - polycarbonate block copolymer. Such blends exhibit a good combination impact strength and flexural properties particularly at relatively high proportions of polyetherimide, and elastomeric behavior at relative high concentrations of the block copolymer of organopolysiloxane and polycarbonate.

  公开了 (a) 聚醚酰亚胺和 (b) 有机聚硅氧烷-聚碳酸酯嵌段共聚物的混合物。这种混合物特别是在聚醚酰亚胺比例相对较高的情况下，显示出良好的冲击强度和挠曲性能组合，而在有机聚硅氧烷和聚碳酸酯嵌段共聚物浓度相对较高的情况下，则显示出良好的弹性特性。
• Sulfonate-terminated polyimides and polyamic acids and method for their preparation
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0176710A2

  公开（公告）日：1986-04-09

  Sulfonate-terminated polyimides and polyamic acids are prepared by the reaction of a dianhydride such as bisphenol A dianhydride, a diamine such as m-phenylenediamine or bis(4-aminophenyl)methane, and an amino sulfonic acid such as p- or m-aminobenzenesulfonic acid or 2-aminoethanesulfonic acid. The products may be used as compatibilizing agents for blends of aromatic polymers with ionomeric elastomers.

  磺酸封端聚酰亚胺和聚酰胺酸是由二酸酐（如双酚 A 二酸酐）、二胺（如间苯二胺或双（4-氨基苯基）甲烷）和氨基磺酸（如对或间氨基苯磺酸或 2-氨基乙磺酸）反应制备而成。 这些产品可用作芳香族聚合物与离子弹性体混合物的相容剂。