ocaperidone succinic acid salt

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: ocaperidone succinic acid salt
• 英文别名: Butanedioic acid;3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2,9-dimethylpyrido[1,2-a]pyrimidin-4-one
• 化学式: C₄H₆O₄*C₂₄H₂₅FN₄O₂
• 分子量: 538.576
• InChiKey: NIQUSYAJMSRKTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.95
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  丁二酸 、 奥卡哌酮 以 四氢呋喃 、 乙醇 为溶剂， 生成 ocaperidone succinic acid salt
  参考文献：
  名称：

  WO2006/90285

  摘要：

  公开号：

文献信息

• Ocaperidone salt and pharmaceutical compositions containing the same
  申请人：NEURO3D

  公开号：EP1695973A1

  公开（公告）日：2006-08-30

  The invention relates to a new salt of ocaperidone and its uses, particularly in the pharmaceutical industry. The invention discloses a specific salt of ocaperidone having increased water solubility, as well as therapeutic methods by administering said salt, in particular for treating various diseases of the central or peripheral nervous system, especially central nervous system. It further deals with pharmaceutical compositions comprising said salt and methods for preparing the same.

  本发明涉及一种新的奥卡哌啶酮盐及其用途，特别是在制药业中的用途。本发明公开了一种具有更高水溶性的奥卡帕里酮特定盐，以及通过施用所述盐进行治疗的方法，特别是用于治疗中枢或外周神经系统，尤其是中枢神经系统的各种疾病。本发明还涉及包含所述盐的药物组合物及其制备方法。
• OCAPERIDONE SALTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
  申请人：Janssen Pharmaceutica NV

  公开号：EP1888577B1

  公开（公告）日：2008-11-12
• Ocaperidone Salts and Pharmaceutical Compositions Containing the Same
  申请人：Biondi Stefano

  公开号：US20080200479A1

  公开（公告）日：2008-08-21

  The invention relates to new salts of ocaperidone and uses thereof, particularly in the pharmaceutical industry. The invention discloses specific salts of ocaperidone having increased water solubilities, as well as therapeutic methods by administering said salts, in particular for treating various diseases of the central or peripheral nervous system, especially central nervous system. It further deals with pharmaceutical compositions comprising said salts and methods for preparing the same.
• [EN] OCAPERIDONE SALTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME<br/>[FR] SELS D'OCAPERIDONE ET LEURS COMPOSITIONS PHARMACEUTIQUES
  申请人：NEURO3D

  公开号：WO2006090285A1

  公开（公告）日：2006-08-31

  [EN] The invention relates to new salts of ocaperidone and uses thereof, particularly in the pharmaceutical industry. The invention discloses specific salts of ocaperidone having increased water solubilities, as well as therapeutic methods by administering said salts, in particular for treating various diseases of the central or peripheral nervous system, especially central nervous system. It further deals with pharmaceutical compositions comprising said salts and methods for preparing the same.
  [FR] L'invention concerne de nouveaux sels d'ocapéridone et leurs utilisations, en particulier, dans l'industrie pharmaceutique. L'invention concerne également des sels spécifiques d'ocapéridone à solubilité dans l'eau améliorée ainsi que des méthodes thérapeutiques permettant d'administrer lesdits sels, en particulier, pour traiter des maladies variées du système nerveux central ou périphérique, notamment du système nerveux central. L'invention concerne enfin des compositions pharmaceutiques comprenant lesdits sels et leurs procédés de préparation.