NPI-2063

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: NPI-2063
• 英文别名: salinosporamide D；(1R,4R,5S)-1-[(S)-[(1S)-cyclohex-2-en-1-yl]-hydroxymethyl]-4,5-dimethyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
• 化学式: C₁₄H₁₉NO₄
• 分子量: 265.309
• InChiKey: XSAPVTUEGDPTEC-BTXSVYSASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2R,3S,4R)-2-((S)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-3-hydroxy-3,4-dimethyl-5-oxopyrrolidine-2-carboxylic acid 在 双(2-氧代-3-恶唑烷基)次磷酰氯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以27 mg的产率得到NPI-2063
  参考文献：
  名称：

  利用手性记忆和动态动力学分辨率首次不对称全合成盐孢菌酰胺 D 和 I

  摘要：

  本文描述的是通过涉及从简单氨基酸丝氨酸快速构建天然产物的吡咯烷酮核心的策略来全合成盐孢菌酰胺。该合成成功的关键是通过单个羟醛环化步骤在吡咯烷酮核心上立体选择性安装三个连续的立构中心，该步骤采用了“手性记忆”和动态动力学解析的原理。

  DOI：

  10.1002/ejoc.202300774

文献信息

• [3.2.0] Heterocyclic compounds and methods of using the same
  申请人：Potts Christine Barbara

  公开号：US20050288352A1

  公开（公告）日：2005-12-29

  Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

  本发明涉及具有抗癌，抗炎和抗微生物特性的I-VI式化合物及其衍生物和类似物，以及包括其中一种或多种化合物及其衍生物或类似物的组合物。还公开了包含这些化合物的药物组合物以及使用公开的化合物或药物组合物治疗癌症，炎症和微生物感染的方法。
• METHODS OF USING [3.2.0] HETEROCYCLIC COMPOUNDS AND ANALOGS THEREOF
  申请人：Palladino Michael

  公开号：US20090182027A1

  公开（公告）日：2009-07-16

  Disclosed are methods of treating cancer, inflammatory conditions, and/or infectious disease in an animal comprising: administering to the animal, a therapeutically effective amount of a heterocyclic compound. The animal is a mammal, preferably a human or a rodent.

  本发明涉及治疗动物癌症、炎症疾病和/或感染性疾病的方法，包括向动物（哺乳动物，优选为人类或啮齿动物）施用有效治疗剂量的杂环化合物。
• Salt formulations for the fermentation of marine microorganisms
  申请人：Celgene International II Sárl

  公开号：US10793824B2

  公开（公告）日：2020-10-06

  Growth medium are disclosed for use in fermenting a marine microorganism. The medium comprise Potassium, Calcium, Strontium, Borate and Fluoride at specific concentrations. Alternatively, the growth medium comprises cobalt at specified concentrations or comprises vitamin B12 at specified concentrations. Methods of producing certain desired compound by fermentation of a marine microorganism are also disclosed.

  公开了用于海洋微生物发酵的生长培养基。培养基包括特定浓度的钾、钙、锶、硼酸盐和氟化物。另外，生长培养基还包括特定浓度的钴或特定浓度的维生素 B12。还公开了通过海洋微生物发酵生产某些所需化合物的方法。
• Methods of using [3.2.0] heterocyclic compounds and analogs thereof
  申请人：Palladino Michael

  公开号：US20070004676A1

  公开（公告）日：2007-01-04

  Disclosed are methods of treating cancer comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula VI. The animal is a mammal, preferably a human or a rodent.
• SALT FORMULATIONS FOR THE FERMENTATION OF MARINE MICROORGANISMS
  申请人：Lam Kin Sing

  公开号：US20080160590A1

  公开（公告）日：2008-07-03

  Growth medium are disclosed for use in fermenting a marine microorganism. The medium comprise Potassium, Calcium, Strontium, Borate and Fluoride at specific concentrations. Alternatively, the growth medium comprises cobalt at specified concentrations or comprises vitamin B 12 at specified concentrations. Methods of producing certain desired compound by fermentation of a marine microorganism are also disclosed.